Association of interferon-γ and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan

• Published in: Clinical and experimental allergy Vol. 36; no. 9; pp. 1147 - 1152
• Main Authors: Wang, T.-N., Chu, Y.-T., Chen, W.-Y., Feng, W.-W., Shih, N.-H., Hsiang, C.-H., Ko, Y.-C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2006; Blackwell
• Subjects: Adult; Allergic diseases; asthma; Asthma - blood; Asthma - genetics; Biological and medical sciences; Child; Family Health; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Humans; IFN regulatory factor 1; IFN-γ; Immunoglobulin E - blood; Immunopathology; Interferon Regulatory Factor-1 - genetics; Interferon-gamma - genetics; Linkage Disequilibrium - genetics; Male; Medical sciences; Phenotype; polymorphism; Polymorphism, Genetic - genetics; Taiwan; Asia; Taiwan; Immunopathology; Lung disease; Allergy; Genetic variability; Respiratory disease; Family study; Genotype; Interferon regulatory factor 1; IFN regulatory factor 1; Asthma; IFN-γ; Immunology; Bronchus disease; Obstructive pulmonary disease; Interferon regulatory factor; Gamma interferon; Polymorphism

Summary Background Asthma is a multi‐factorial disorder caused by complex interactions between genetic and environmental factors. IFN‐γ and IFN regulatory factor 1 (IRF‐1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma. Obje...