Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment

• Published in: Headache Vol. 52; no. 9; pp. 1350 - 1361
• Main Authors: Perrotta, Armando, Arce-Leal, Natalia, Tassorelli, Cristina, Gasperi, Valeria, Sances, Grazia, Blandini, Fabio, Serrao, Mariano, Bolla, Monica, Pierelli, Francesco, Nappi, Giuseppe, Maccarrone, Mauro, Sandrini, Giorgio
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.10.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Amidohydrolases - metabolism; Analgesics - adverse effects; Biological and medical sciences; Cannabinoids; endocannabinoid system; Enzymes; Fatty acids; Fatty-acid amide hydrolase; Female; Headache; Headache - chemically induced; Headache - metabolism; Headache - physiopathology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Headaches; Humans; Information processing; Male; Medical sciences; medication-overuse headache; Migraine; Nervous system (semeiology, syndromes); Neural Pathways - metabolism; Neural Pathways - physiopathology; Neurology; nociceptive withdrawal reflex; Pain; Pain - metabolism; Pain - physiopathology; Pain perception; Pain Threshold - physiology; Platelets; Reflex - physiology; Reflexes; Spinal cord; spinal sensitization; Substance-Related Disorders - complications; temporal summation; Temporal variations; Vascular diseases and vascular malformations of the nervous system; Facilitation; Human; Headache; Nervous system diseases; temporal summation; Enzyme; medication-overuse headache; Cerebral disorder; Chemotherapy; Treatment; Pain; Treatment withdrawal; spinal sensitization; Central nervous system disease; nociceptive withdrawal reflex; Hydrolases; endocannabinoid system; Neurological disorder; Cerebrovascular disease

Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both. Background.— The endocannabinoid system...