Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment - Perrotta, Armando; Arce-Leal, Natalia; Tassorelli, Cristina; Gasperi, Valeria; Sances, Grazia; Blandini, Fabio; Serrao, Mariano; Bolla, Monica; Pierelli, Francesco; Nappi, Giuseppe; Maccarrone, Mauro; Sandrini, Giorgio (Headache, 2012)
Keywords: Adult; Amidohydrolases - metabolism; Analgesics - adverse effects; Biological and medical sciences; Cannabinoids; endocannabinoid system; Enzymes; Fatty acids; Fatty-acid amide hydrolase; Female; Headache; Headache - chemically induced; Headache - metabolism; Headache - physiopathology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Headaches; Humans; Information processing; Male; Medical sciences; medication-overuse headache; Migraine; Nervous system (semeiology, syndromes); Neural Pathways - metabolism; Neural Pathways - physiopathology; Neurology; nociceptive withdrawal reflex; Pain; Pain - metabolism; Pain - physiopathology; Pain perception; Pain Threshold - physiology; Platelets; Reflex - physiology; Reflexes; Spinal cord; spinal sensitization; Substance-Related Disorders - complications; temporal summation; Temporal variations; Vascular diseases and vascular malformations of the nervous system; Facilitation; Human; Headache; Nervous system diseases; temporal summation; Enzyme; medication-overuse headache; Cerebral disorder; Chemotherapy; Treatment; Pain; Treatment withdrawal; spinal sensitization; Central nervous system disease; nociceptive withdrawal reflex; Hydrolases; endocannabinoid system; Neurological disorder; Cerebrovascular disease