Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment
Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both. Background.— The endocannabinoid system...
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| Published in | Headache Vol. 52; no. 9; pp. 1350 - 1361 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.10.2012
Wiley-Blackwell Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both.
Background.— The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication‐overuse headache.
Methods.— We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication‐overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls.
Results.— A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication‐overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication‐overuse headache subjects before withdrawal treatment.
Conclusions.— We demonstrated a marked facilitation in spinal cord pain processing in medication‐overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. |
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| AbstractList | We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication-overuse headache, and (2) the effect of withdrawal treatment on both.
The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication-overuse headache.
We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls.
A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment.
We demonstrated a marked facilitation in spinal cord pain processing in medication-overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. Objectives.- We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication-overuse headache, and (2) the effect of withdrawal treatment on both. Background.- The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication-overuse headache. Methods.- We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. Results.- A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment. Conclusions.- We demonstrated a marked facilitation in spinal cord pain processing in medication-overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both. Background.— The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication‐overuse headache. Methods.— We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication‐overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. Results.— A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication‐overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication‐overuse headache subjects before withdrawal treatment. Conclusions.— We demonstrated a marked facilitation in spinal cord pain processing in medication‐overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both. Background.— The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication‐overuse headache. Methods.— We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication‐overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. Results.— A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication‐overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication‐overuse headache subjects before withdrawal treatment. Conclusions.— We demonstrated a marked facilitation in spinal cord pain processing in medication‐overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication-overuse headache, and (2) the effect of withdrawal treatment on both.OBJECTIVESWe investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication-overuse headache, and (2) the effect of withdrawal treatment on both.The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication-overuse headache.BACKGROUNDThe endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication-overuse headache.We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls.METHODSWe used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls.A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment.RESULTSA significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment.We demonstrated a marked facilitation in spinal cord pain processing in medication-overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect.CONCLUSIONSWe demonstrated a marked facilitation in spinal cord pain processing in medication-overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. Objectives.-- We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication-overuse headache, and (2) the effect of withdrawal treatment on both. Background.-- The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication-overuse headache. Methods.-- We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication-overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. Results.-- A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication-overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication-overuse headache subjects before withdrawal treatment. Conclusions.-- We demonstrated a marked facilitation in spinal cord pain processing in medication-overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. [PUBLICATION ABSTRACT] |
| Author | Bolla, Monica Sances, Grazia Maccarrone, Mauro Sandrini, Giorgio Pierelli, Francesco Arce-Leal, Natalia Blandini, Fabio Perrotta, Armando Tassorelli, Cristina Gasperi, Valeria Nappi, Giuseppe Serrao, Mariano |
| Author_xml | – sequence: 1 givenname: Armando surname: Perrotta fullname: Perrotta, Armando email: arm.perrotta@gmail.com organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 2 givenname: Natalia surname: Arce-Leal fullname: Arce-Leal, Natalia organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 3 givenname: Cristina surname: Tassorelli fullname: Tassorelli, Cristina organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 4 givenname: Valeria surname: Gasperi fullname: Gasperi, Valeria organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 5 givenname: Grazia surname: Sances fullname: Sances, Grazia organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 6 givenname: Fabio surname: Blandini fullname: Blandini, Fabio organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 7 givenname: Mariano surname: Serrao fullname: Serrao, Mariano organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 8 givenname: Monica surname: Bolla fullname: Bolla, Monica organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 9 givenname: Francesco surname: Pierelli fullname: Pierelli, Francesco organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 10 givenname: Giuseppe surname: Nappi fullname: Nappi, Giuseppe organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 11 givenname: Mauro surname: Maccarrone fullname: Maccarrone, Mauro organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) – sequence: 12 givenname: Giorgio surname: Sandrini fullname: Sandrini, Giorgio organization: From the Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy (A. Perrotta and N. Arce-Leal); Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy (N. Arce-Leal, C. Tassorelli, and G. Sandrini); Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy (C. Tassorelli, G. Sances, M. Bolla, G. Nappi, and Giorgio Sandrini); Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy (V. Gasperi); Laboratory of Functional Neurochemistry, Interdepartmental Research Centre for Parkinson's Disease, IRCCS National Institute of Neurology "C. Mondino," Pavia, Italy (F. Blandini); Department of Medical and Surgical Science and Biotecnology, Sapienza University of Rome, Rome, Italy (M. Serrao and F. Pierelli); Department of Biomedical Sciences, University of Teramo, Teramo, Italy, and European Center for Brain Research (CERC)/IRCCS Fondazione Santa Lucia, Rome, Italy (M. Maccarrone) |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26506991$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22670561$$D View this record in MEDLINE/PubMed |
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| Keywords | Facilitation Human Headache Nervous system diseases temporal summation Enzyme medication-overuse headache Cerebral disorder Chemotherapy Treatment Pain Treatment withdrawal spinal sensitization Central nervous system disease nociceptive withdrawal reflex Hydrolases endocannabinoid system Neurological disorder Cerebrovascular disease |
| Language | English |
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| Notes | ArticleID:HEAD2170 istex:5CC6191E851FCA51EE5030561FD32425075BE7E4 ark:/67375/WNG-P56FV9NC-7 This study was supported by grants issued by the Italian Ministry of Health (RC2009 to G.S.) and partly by Fondazione Cassa di Risparmio di Teramo (research grant 2009‐2012 to M.M.). Conflict of Interest Contributed equally to this work. No conflict of interests are declared by the authors. Financial support ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
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| References_xml | – reference: Johanek LM, Simone DA. Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons. J Neurophysiol. 2005;93:989-997. – reference: Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience. 1998;83:393-411. – reference: Akerman S, Kaube H, Goadsby PJ. Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. J Pharmacol Exp Ther. 2004;309:56-63. – reference: Cupini LM, Bari M, Battista N, et al. Biochemical changes in endocannabinoid system are expressed in platelets of female but not male migraineurs. Cephalalgia. 2006;26:277-281. – reference: Cupini LM, Costa C, Sarchielli P, et al. Degradation of endocannabinoids in chronic migraine and medication overuse headache. Neurobiol Dis. 2008;30:186-189. – reference: Maldonado R, Valverde O, Berrendero F. Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 2006;29:225-232. – reference: Perrotta A, Serrao M, Tassorelli C, et al. Oral nitric-oxide donor glyceryl-trinitrate induces sensitization in spinal cord pain processing in migraineurs: A double-blind, placebo-controlled, cross-over study. Eur J Pain. 2011;15:482-490. – reference: Farquhar-Smith WP, Egertova M, Bradbury EJ, McMahon SB, Rice AS, Elphick MR. Cannabinoid CB(1) receptor expression in rat spinal cord. Mol Cell Neurosci. 2000;15:510-521. – reference: Bruehl S, Harden RN, Galer BS, et al. External validation of IASP diagnostic criteria for complex regional pain syndrome and proposed research diagnostic criteria. International Association for the Study of Pain. Pain. 1999;81:147-154. – reference: Price DD. Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Exp Neurol. 1972;37:371-387. – reference: Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc Natl Acad Sci U S A. 2004;101:10821-10826. – reference: Herkenham M, Lynn AB, Little MD, et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A. 1990;87:1932-1936. – reference: Iversen L, Chapman V. Cannabinoids: A real prospect for pain relief? Curr Opin Pharmacol. 2002;2:50-55. – reference: Sarchielli P, Pini LA, Coppola F, et al. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. Neuropsychopharmacology. 2007;32:1384-1390. – reference: Calabresi P, Cupini LM. Medication-overuse headache: Similarities with drug addiction. Trends Pharmacol Sci. 2005;26:62-68. – reference: Cravatt BF, Demarest K, Patricelli MP, et al. 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| Snippet | Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing... Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing... We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in... Objectives.-- We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing... Objectives.- We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing... |
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| SubjectTerms | Adult Amidohydrolases - metabolism Analgesics - adverse effects Biological and medical sciences Cannabinoids endocannabinoid system Enzymes Fatty acids Fatty-acid amide hydrolase Female Headache Headache - chemically induced Headache - metabolism Headache - physiopathology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Headaches Humans Information processing Male Medical sciences medication-overuse headache Migraine Nervous system (semeiology, syndromes) Neural Pathways - metabolism Neural Pathways - physiopathology Neurology nociceptive withdrawal reflex Pain Pain - metabolism Pain - physiopathology Pain perception Pain Threshold - physiology Platelets Reflex - physiology Reflexes Spinal cord spinal sensitization Substance-Related Disorders - complications temporal summation Temporal variations Vascular diseases and vascular malformations of the nervous system |
| Title | Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment |
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