Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

• Published in: Nature communications Vol. 10; no. 1; pp. 1 - 10
• Main Authors: Liu, Jia, Hao, Shengnan, Chen, Xi, Zhao, Hui, Du, Lutao, Ren, Hanxiao, Wang, Chuanxin, Mao, Haiting
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.10.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/21; 13/31; 13/51; 14/1; 631/250/127/1213; 631/250/1619/554/1898/1271; 631/250/2152/569/2495; 631/250/516; 64/60; Cell proliferation; Chemokines; Cytokines; Fetuses; Genotype & phenotype; Humanities and Social Sciences; Immunological tolerance; Immunology; In vivo methods and tests; Interleukins; Lymphocytes; Lymphocytes T; Miscarriage; multidisciplinary; Phosphorylation; Placenta; Pregnancy; Proteins; Science; Science (multidisciplinary); Stat1 protein; Stat3 protein; Transcription factors; Trophoblasts; Womens health

During pregnancy, trophoblast cells sustain the maternal–fetal tolerance via expressing and secreting various chemokines and cytokines. Our previous study revealed the expression of interleukin-35 (IL-35) in human first-trimester trophoblasts. Here we show that IL-35 is expressed in both human first...