Neuroimaging predictors of transition to psychosis—A systematic review and meta-analysis

• Published in: Neuroscience and biobehavioral reviews Vol. 34; no. 8; pp. 1207 - 1222
• Main Authors: Smieskova, R., Fusar-Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R.D., Drewe, J., Radue, E.W., McGuire, P.K., Riecher-Rössler, A., Borgwardt, S.J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.07.2010; Elsevier
• Subjects: Adult and adolescent clinical studies; At-risk mental state (ARMS); Biological and medical sciences; Brain - pathology; Brain Mapping; Cerebellum; Diagnostic Imaging; Functional magnetic resonance imaging (fMRI); High-risk; Humans; Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); Medical sciences; Meta-analysis; Other psychotic disorders; Positron emission tomography (PET); Predictive Value of Tests; Prodromal; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Psychotic Disorders - diagnosis; Risk Factors; Schizophrenia; Structural magnetic resonance imaging (sMRI); Transition; Psychosis; Structural magnetic resonance imaging (sMRI); Positron emission tomography (PET); Magnetic resonance spectroscopy (MRS); Schizophrenia; Transition; Magnetic resonance imaging (MRI); Functional magnetic resonance imaging (fMRI); At-risk mental state (ARMS); High-risk; Meta-analysis; Prodromal; High risk; Volumetric analysis; sMRI; Structural magnetic resonance imaging; Central nervous system; Prodrome; NMR spectrometry; Review; Encephalon; Metaanalysis; Functional magnetic resonance imaging; Human; Metabolism; Nuclear magnetic resonance imaging; fMRI; Risk factor; Predictive factor; Positron emission tomography; Functional imaging; Emission tomography

In early stage psychosis research the identification of neurobiological correlates of vulnerability to schizophrenia is an important hurdle. We systematically reviewed the neuroimaging publications on high-risk subjects with subsequent transition to psychosis (HR-T) and conducted a meta-analysis cal...