Structural basis of CD4 downregulation by HIV-1 Nef - Kwon, Yonghwa; Kaake, Robyn M.; Echeverria, Ignacia; Suarez, Marissa; Karimian Shamsabadi, Mohammad; Stoneham, Charlotte; Ramirez, Peter W.; Kress, Jacob; Singh, Rajendra; Sali, Andrej; Krogan, Nevan; Guatelli, John; et al. (Nature structural & molecular biology, 2020)
Keywords: 101/58; 13/31; 631/326/596; 631/535/1266; 82; Adaptor Protein Complex 2 - chemistry; Adaptor Protein Complex 2 - metabolism; Adaptor proteins; Binding; Biochemistry; Biological Microscopy; Biomedical and Life Sciences; CD4 antigen; CD4 Antigens - chemistry; CD4 Antigens - metabolism; Cell surface; Cell surface receptors; Clathrin; Crystal structure; Crystallography; Crystallography, X-Ray; Down-regulation; Drug development; Endocytosis; Fusion protein; HeLa Cells; HIV; HIV Infections - metabolism; HIV-1 - physiology; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Immune clearance; Immunosurveillance; Life Sciences; Major histocompatibility complex; Membrane Biology; Models, Molecular; Mutagenesis; nef Gene Products, Human Immunodeficiency Virus - chemistry; nef Gene Products, Human Immunodeficiency Virus - metabolism; Nef protein; Pathogenesis; Protein Binding; Protein Conformation; Protein Domains; Protein Structure; Proteins; Viruses