A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

• Published in: Translational psychiatry Vol. 10; no. 1; p. 50
• Main Authors: Fabbri, Chiara, Kasper, Siegfried, Kautzky, Alexander, Zohar, Joseph, Souery, Daniel, Montgomery, Stuart, Albani, Diego, Forloni, Gianluigi, Ferentinos, Panagiotis, Rujescu, Dan, Mendlewicz, Julien, Uher, Rudolf, Lewis, Cathryn M., Serretti, Alessandro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.02.2020; Nature Publishing Group
• Subjects: 45; 45/23; 45/43; 631/208/212/1728; 692/53/2423; Behavioral Sciences; Biological Psychology; Depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; Depressive Disorder, Treatment-Resistant - drug therapy; Depressive Disorder, Treatment-Resistant - genetics; Exome Sequencing; Genomes; Genotype; Humans; Medicine; Medicine & Public Health; Neurosciences; Pharmacotherapy; Psychiatry; Treatment resistance

Treatment-resistant depression (TRD) occurs in ~30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotyping were available in 1209 MDD patients after quality control. Antidepressant response was co...