Splenic irradiation contributes to grade ≥ 3 lymphopenia after adjuvant chemoradiation for stomach cancer

• Published in: Clinical and translational radiation oncology Vol. 36; pp. 83 - 90
• Main Authors: Lee, Shing Fung, Yip, Pui Lam, Wong, Aray, Ng, Francesca, Koh, Vicky, Wong, Lea Choung, Luk, Hollis, Ng, Chuk Kwan, Lee, Francis Ann Shing, Mamon, Harvey J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2022; Elsevier
• Subjects: Gastric cancer; Normal tissue toxicity; Original; Postoperative chemoradiotherapy; Spleen; Survival; Spleen; Normal tissue toxicity; Gastric cancer; Survival; Postoperative chemoradiotherapy

•Severe lymphopenia occurs commonly after adjuvant chemoradiation for gastric cancer.•High splenic radiation doses increase the chances of severe lymphopenia.•Severe lymphopenia predicts a poorer overall survival and higher risk of infections.•The spleen is not routinely considered an organ-at-risk...