Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway

• Published in: iScience Vol. 25; no. 7; p. 104533
• Main Authors: Liu, Yang, He, Libo, Liu, Binghua, Ying, Yuling, Xu, Junling, Yu, Meng, Dang, Jinye, Liu, Ke
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.07.2022; Elsevier
• Subjects: Biological sciences; Cell biology; Cellular neuroscience; Neuroscience; Cell biology; Neuroscience; Biological sciences; Cellular neuroscience

Ferroptosis is crucial to the pathology of many neurological diseases. Here, we found pre-treatment with myriocin, an inhibitor of de novo synthesis of sphingolipid, significantly decreased the erastin- or glutamate-induced ferroptosis of HT22 cells without requiring the recovery of intracellular gl...