The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

• Published in: Nature reviews. Endocrinology Vol. 16; no. 2; pp. 81 - 90
• Main Authors: Ying, Wei, Fu, Wenxian, Lee, Yun Sok, Olefsky, Jerrold M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2020; Nature Publishing Group
• Subjects: 631/250/2504/342; 692/163/2743/137; 692/163/2743/393; 692/698/1460/1583; 692/699/2743/2815; Adipose tissue; Animals; Beta cells; Blood glucose; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Endocrinology; Humans; Hyperplasia; Inflammation; Inflammation - immunology; Inflammation - metabolism; Insulin; Insulin-Secreting Cells - immunology; Insulin-Secreting Cells - metabolism; Islets of Langerhans - immunology; Islets of Langerhans - metabolism; Macrophages; Macrophages - physiology; Medicine; Medicine & Public Health; Obesity; Obesity - immunology; Obesity - metabolism; Pancreas; Platelet-derived growth factor; Review Article

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2 diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue and liver inflammation have been particularly well studied; however, abundant evidence demonstrates that inflammatory pr...