Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

• Published in: Nature communications Vol. 15; no. 1; p. 541
• Main Authors: Drexhage, Linnea Z, Zhang, Shengpan, Dupont, Maeva, Ragaller, Franziska, Sjule, Ellen, Cabezas-Caballero, Jose, Deimel, Lachlan P, Robertson, Helen, Russell, Rebecca A, Dushek, Omer, Sezgin, Erdinc, Karaji, Niloofar, Sattentau, Quentin J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 15.01.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: ADAM10 Protein - genetics; Amyloid Precursor Protein Secretases; Apoptosis; Cell death; Cell surface; Clearances; Efferocytosis; Glycoproteins; Homeostasis; Humans; Immune clearance; Lymphocytes; Lymphocytes T; Macrophages; Medicin och hälsovetenskap; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mucin; Mucins; Phagocytes; Phagocytosis; Phosphatidylserine; T-Lymphocytes - metabolism

Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to phagocytosis. Whether and how mucins may be regulated d...