Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii

• Published in: Journal of antibiotics Vol. 74; no. 6; pp. 370 - 380
• Main Authors: Deering, Robert W., Whalen, Kristen E., Alvarez, Ivan, Daffinee, Kathryn, Beganovic, Maya, LaPlante, Kerry L., Kishore, Shreya, Zhao, Sijing, Cezairliyan, Brent, Yu, Shen, Rosario, Margaret, Mincer, Tracy J., Rowley, David C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2021; Nature Publishing Group
• Subjects: 631/154/436/108; 631/326/22/1290; Acinetobacter baumannii - drug effects; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - chemistry; Bacterial Proteins - metabolism; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Bradyrhizobium - metabolism; Drug Antagonism; Drug resistance; Drug Resistance, Multiple, Bacterial - drug effects; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Life Sciences; Medicinal Chemistry; Microbial Sensitivity Tests; Microbiology; Molecular Docking Simulation; Molecular Structure; Organic Chemistry; Oxo-Acid-Lyases - antagonists & inhibitors; Oxo-Acid-Lyases - chemistry; Oxo-Acid-Lyases - metabolism; Parabens - pharmacology; Pathogens; Pseudomonas aeruginosa - drug effects

The emergence of multi-drug resistant pathogenic bacteria represents a serious and growing threat to national healthcare systems. Most pressing is an immediate need for the development of novel antibacterial agents to treat Gram-negative multi-drug resistant infections, including the opportunistic,...