Organoid models of gastrointestinal cancers in basic and translational research

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 17; no. 4; pp. 203 - 222
• Main Authors: Lau, Harry Cheuk Hay, Kranenburg, Onno, Xiao, Haipeng, Yu, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2020; Nature Publishing Group
• Subjects: 631/1647/767/2199; 692/4020/1503/1504; Animal models; Biomedicine; Cell culture; Cell Culture Techniques - methods; Coculture Techniques; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Drug discovery; Drug Screening Assays, Antitumor - methods; Esophageal cancer; Esophagus; Gastric cancer; Gastroenterology; Gastrointestinal cancer; Gastrointestinal Microbiome; Gastrointestinal Neoplasms - pathology; Gastrointestinal tract; Hepatology; Humans; Liver cancer; Medicine; Medicine & Public Health; Metastases; Metastasis; Methods; Models, Biological; Organoids; Organoids - pathology; Pancreatic cancer; Pharmacology, Experimental; Precision medicine; Precision Medicine - methods; Public health; R&D; Research & development; Review Article; Translation; Translational Research, Biomedical - methods; Tumor cell lines; Tumors; Hong Kong, China

Cancer is a major public health problem worldwide. Gastrointestinal cancers account for approximately one-third of the total global cancer incidence and mortality. Historically, the mechanisms of tumour initiation and progression in the gastrointestinal tract have been studied using cancer cell line...