Pre-treatment with angiotensin-(1–7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 96; no. 12; pp. 1407 - 1418
• Main Authors: Lin, Yu-Tsai, Wang, Hung-Chen, Chuang, Hui-Ching, Hsu, Yi-Chiang, Yang, Ming-Yu, Chien, Chih-Yen
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Angiogenesis; Angiotensin; Angiotensin I - pharmacology; Angiotensin I - therapeutic use; Animals; Antitumor activity; Autophagy; Autophagy - drug effects; Bcl-2 protein; Biomedical and Life Sciences; Biomedicine; Cancer therapies; Cell growth; Cell Line, Tumor; Cell migration; Cell proliferation; Chemotherapy; Down-Regulation - drug effects; Human Genetics; Humans; Internal Medicine; Kinases; Male; Mice, Nude; Molecular Medicine; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - drug therapy; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Original; Original Article; Peptide Fragments - pharmacology; Peptide Fragments - therapeutic use; Phagocytosis; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Radiation therapy; Renin; Signal transduction; Signal Transduction - drug effects; Throat cancer; TOR protein; TOR Serine-Threonine Kinases - metabolism; Tumors; Xenograft Model Antitumor Assays; Xenografts; Nasopharyngeal carcinoma; Angiotensin-(1–7); Pre-treatment; Autophagy; PI3K/Akt/mTOR signaling

The highest incidence of nasopharyngeal carcinoma (NPC) is in southeast China, including Taiwan. Many side effects have been observed following radiation therapy with chemotherapy; hence, exploring new treatment modalities for NPC is an important future direction. Angiotensin-(1–7) [Ang-(1–7)] is an...