miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium

• Published in: Toxicology letters Vol. 229; no. 1; pp. 319 - 326
• Main Authors: Li, Yang, Li, Ping, Yu, Shanfa, Zhang, Ji, Wang, Tiancheng, Jia, Guang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 17.08.2014
• Subjects: Adult; Blood; Carcinogens, Environmental - toxicity; Chromium; Chromium - blood; Chromium - toxicity; Damage; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; Deoxyribonucleic acid; DNA Damage; DNA Repair - drug effects; DNA Repair - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Enzyme-Linked Immunosorbent Assay; Exposure; Female; Gene expression; Genes; Genetic damage; Genetics; Hexavalent chromium; Humans; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metallurgy; Micronucleus Tests; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Mutagens; Occupational Exposure - adverse effects; Real-Time Polymerase Chain Reaction; Transcription, Genetic - drug effects; Na2Cr2O7; NSCLC; IQR; Hexavalent chromium; Genetic damage; Cr(VI); KHSRP; miRNA; ICP-MS; CBMN; 8-OHdG; ELISA; BMI

•Plasma miR-3940-5p is significantly decreased by hexavalent chromium exposure.•Hexavalent chromium exposure can increase micronuclei frequency in peripheral lymphocytes, but micronuclei frequency does not continue to increase at a higher hexavalent chromium exposure.•miR-3940-5p modulates hexavalen...