Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice

• Published in: The Journal of clinical investigation Vol. 134; no. 7; pp. 1 - 20
• Main Authors: Bergamasco, Maria I, Vanyai, Hannah K, Garnham, Alexandra L, Geoghegan, Niall D, Vogel, Adam P, Eccles, Samantha, Rogers, Kelly L, Smyth, Gordon K, Blewitt, Marnie E, Hannan, Anthony J, Thomas, Tim, Voss, Anne K
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.04.2024
• Subjects: Acetylation; Alzheimer's disease; Analysis; Animal models; Autism; Blood cells; Brain; Care and treatment; Carnitine; Cells; Chromatin; CRISPR; Diagnosis; Divalproex; Fetuses; Gene expression; Genetic aspects; Genetic screening; Health aspects; Histone deacetylase; Histone H3; Histones; Intellectual disabilities; Mental retardation; Mice; Morphology; Mutation; Phenotype; Proteins; Social discrimination learning; Therapeutic applications; Valproic acid; Weaning; Australia; Development; Epigenetics; Neurodevelopment; Genetics; Genetic diseases

Mutations in genes encoding chromatin modifiers are enriched among mutations causing intellectual disability. The continuing development of the brain postnatally, coupled with the inherent reversibility of chromatin modifications, may afford an opportunity for therapeutic intervention following a ge...