Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

• Published in: Neurobiology of disease Vol. 22; no. 2; pp. 223 - 232
• Main Authors: Butterfield, D. Allan, Poon, H. Fai, St. Clair, Daret, Keller, Jeffery N., Pierce, William M., Klein, Jon B., Markesbery, William R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2006; Elsevier
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - enzymology; Alzheimer Disease - physiopathology; Biomarkers, Tumor - metabolism; Cell Proliferation; Cognition Disorders - enzymology; Cognition Disorders - physiopathology; DNA-Binding Proteins - metabolism; Energy Metabolism - physiology; Enzyme Activation - physiology; Female; Glutamate-Ammonia Ligase - metabolism; Hippocampus - enzymology; Hippocampus - physiopathology; Humans; Male; Nerve Tissue Proteins - metabolism; Neuronal Plasticity - physiology; NIMA-Interacting Peptidylprolyl Isomerase; Oxidation-Reduction; Oxidative Stress - physiology; Peptidylprolyl Isomerase - metabolism; Phosphopyruvate Hydratase - metabolism; Protein Processing, Post-Translational - physiology; Proteomics; Pyruvate Kinase - metabolism; Tumor Suppressor Proteins - metabolism

Mild cognitive impairment (MCI) is generally referred to the transitional zone between normal cognitive function and early dementia or clinically probable Alzheimer's disease (AD). Oxidative stress plays a significant role in AD and is increased in the superior/middle temporal gyri of MCI subje...