RING-dependent tumor suppression and G2 M arrest induced by the TRC8 hereditary kidney cancer gene
TRC8/RNF139 and von Hippel-Lindau (VHL) both encode E3 ubiquitin (Ub) ligases mutated in clear-cell renal carcinomas (ccRCC). VHL, inactivated in nearly 70% of ccRCCs, is a tumor suppressor encoding the targeting subunit for a Ub ligase complex that downregulates hypoxia-inducible factor-alpha. TRC8...
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Published in | Oncogene Vol. 26; no. 16; pp. 2263 - 2271 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Basingstoke
Nature Publishing
05.04.2007
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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