In vitro oxidized HDL and HDL from type 2 diabetes patients have reduced ability to efflux oxysterols from THP-1 macrophages

• Published in: Biochimie Vol. 153; pp. 232 - 237
• Main Authors: Chen, Yinan, Arnal-Levron, Maud, Hullin-Matsuda, Françoise, Knibbe, Carole, Moulin, Philippe, Luquain-Costaz, Céline, Delton, Isabelle
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.10.2018; Elsevier
• Subjects: 7-Ketocholesterol; apolipoprotein A-I; Biochemistry, Molecular Biology; Biological Transport; Case-Control Studies; Cholesterol; cytotoxicity; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Female; Glucose - metabolism; glycation; High density lipoprotein; Humans; Life Sciences; lipid peroxidation; Lipoproteins, HDL - metabolism; low density lipoprotein; Macrophages; Macrophages - metabolism; Male; noninsulin-dependent diabetes mellitus; oxidation; Oxidation-Reduction; oxidative stress; Oxysterols; Oxysterols - metabolism; patients; Sterol efflux; THP-1 Cells; Type 2 diabetes; Type 2 diabetes; High density lipoprotein; 7-Ketocholesterol; CHO; glycoHDL; Macrophages; Cholesterol; OXY; HDL; glyHDL; oxHDL; LDL; Oxysterols; 7-KC; Sterol efflux

Oxidized LDL (OxLDL) that are enriched in products of lipid peroxidation including oxysterols have been shown to induce cellular oxidative stress and cytotoxicity therefore accelerating atheroma plaque formation. Upon oxLDL exposure of THP-1 macrophages, intracellular oxidation of LDL derived-choles...