Clinical autologous in vitro endothelialization of 153 infrainguinal ePTFE grafts

• Published in: The Annals of thoracic surgery Vol. 71; no. 5; pp. S327 - S331
• Main Authors: Meinhart, Johann G, Deutsch, Manfred, Fischlein, Teddy, Howanietz, Norbert, Fröschl, Alexander, Zilla, Peter
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2001; Elsevier Science
• Subjects: Aged; Biological and medical sciences; Blood Vessel Prosthesis; Cell Transplantation; Cells, Cultured; Coated Materials, Biocompatible; Endothelium - cytology; Endothelium - transplantation; Equipment Failure Analysis; Female; Follow-Up Studies; Graft Occlusion, Vascular - pathology; Humans; Ischemia - surgery; Leg - blood supply; Male; Medical sciences; Middle Aged; Polytetrafluoroethylene; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Composite graft; Human; Cell culture; Endothelial cell; Prognosis; Prosthesis; Tetrafluoroethylene polymer; Mortality; Homograft; Lower limb; Exploration; Seeding; Morbidity; Endothelium; Bypass; Surgery; Graft; Femoropopliteal; Biomaterial; Hemodynamics

Background. Over the past 17 years, our group has developed and clinically applied an in vitro endothelialization procedure whereby infrainguinal expanded polytetrafluoroethylene (ePTFE) prostheses are confluently lined with cultured autologous endothelial cells before implantation. After a successf...