Development of next generation medical countermeasures to nerve agent poisoning

• Published in: Toxicology (Amsterdam) Vol. 233; no. 1; pp. 120 - 127
• Main Authors: Wetherell, Janet, Price, Matthew, Mumford, Helen, Armstrong, Stuart, Scott, Leah
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Shannon Elsevier Ireland Ltd 20.04.2007; Amsterdam Elsevier Science
• Subjects: Animals; Antidotes - administration & dosage; Antidotes - therapeutic use; Atropine - administration & dosage; Atropine - therapeutic use; Biological and medical sciences; Chemical Warfare Agents - poisoning; Dipeptides - administration & dosage; Dipeptides - therapeutic use; Disease Models, Animal; Drug Therapy, Combination; Emergency; Guinea Pigs; Guinea-pig; Ileal Diseases - chemically induced; Ileal Diseases - prevention & control; Incapacitation; Intussusception; Intussusception - chemically induced; Intussusception - prevention & control; Lethal Dose 50; Lethality; Male; Medical sciences; Nerve agent; Neurotoxicity Syndromes - prevention & control; Oximes; Physostigmine - administration & dosage; Physostigmine - therapeutic use; Primates; Pyridinium Compounds - administration & dosage; Pyridinium Compounds - therapeutic use; Scopolamine Derivatives - administration & dosage; Scopolamine Derivatives - therapeutic use; Soman - poisoning; Therapy; Time Factors; Toxicology; Therapy; Lethality; Guinea-pig; Nerve agent; Incapacitation; Intussusception; Rodentia; Medicine; Toxin; Vertebrata; Mammalia; Guinea pig; Treatment; Animal; Neurotoxin; Development; Poisoning

Abstract Medical countermeasures provide a key role in the UK integrated approach to chemical defence and are aimed at preventing or mitigating the effects of exposure to nerve agents. It is UK policy that medical countermeasures will be licensed products. Demonstration of efficacy relies on extrapo...