Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production

• Published in: BMC veterinary research Vol. 15; no. 1; p. 380
• Main Authors: Watari, Kei, Konnai, Satoru, Maekawa, Naoya, Okagawa, Tomohiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.10.2019; BMC
• Subjects: Animals; Antibodies; antigens; B7-1 Antigen; B7-2 Antigen; BLV; Bovine leukemia virus; Cattle; CD80; CD86; Chlorocebus aethiops; chronic diseases; COS Cells; CTLA-4; CTLA-4 Antigen - genetics; CTLA-4 Antigen - metabolism; cytotoxicity; disease progression; dose response; enterotoxins; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; IFN-γ; immune response; interferon-gamma; Interferon-gamma - genetics; Interferon-gamma - metabolism; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; monoclonal antibodies; neoplasms; Recombinant Proteins; Staphylococcus; T-lymphocytes; therapeutics; CD86; IFN-γ; CTLA-4; Cattle; BLV; CD80

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a homeostasis of the immune response. Recent studies have...