Ultraviolet-B Exposure of Human Skin Induces Cytochromes P450 1A1 and 1B1

• Published in: Journal of investigative dermatology Vol. 114; no. 2; pp. 328 - 333
• Main Authors: Katiyar, Santosh K., Mukhtar, Hasan, Matsui, Mary S.
• Format: Journal Article
• Language: English
• Published: Danvers, MA Elsevier Inc 01.02.2000; Nature Publishing; Elsevier Limited
• Subjects: Adult; Aryl Hydrocarbon Hydroxylases; Biological and medical sciences; Biological effects of radiation; Cytochrome P-450 CYP1A1 - biosynthesis; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System - biosynthesis; cytochromes P450; Dose-Response Relationship, Radiation; Enzyme Induction - radiation effects; Female; Fundamental and applied biological sciences. Psychology; human skin; Humans; Immunohistochemistry; Male; Middle Aged; Non ionizing radiations. Hertzian waves. Biooptics; reverse transcription polymerase chain reaction; Skin - enzymology; Skin - radiation effects; Tissue Distribution; Tissues, organs and organisms biophysics; ultraviolet; Ultraviolet Rays; reverse transcription polymerase chain reaction; cytochromes P450; immunohistochemistry; ultraviolet; human skin; Human; Carcinogen; UVB radiation; Cytochrome P450; Skin; Biological effect; Experimental study

The cytochromes P450 belong to a multigene superfamily and are responsible for the metabolic activation of both xenobiotics and endobiotics. The expression of cytochrome P450 genes in target cells is an important determinant of human susceptibility to cancers and other chemically initiated diseases....