Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

• Published in: Cell death & disease Vol. 10; no. 12; pp. 934 - 16
• Main Authors: Kung-Chun Chiu, David, Pui-Wah Tse, Aki, Law, Cheuk-Ting, Ming-Jing Xu, Iris, Lee, Derek, Chen, Mengnuo, Kit-Ho Lai, Robin, Wai-Hin Yuen, Vincent, Wing-Sum Cheu, Jacinth, Wai-Hung Ho, Daniel, Wong, Chun-Ming, Zhang, Huafeng, Ng, Irene Oi-Lin, Chak-Lui Wong, Carmen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2019; Springer Nature B.V
• Subjects: 13; 13/1; 13/106; 13/109; 13/31; 13/51; 14; 14/28; 38; 631/67/2327; 631/80/86/2366; Animals; Antibodies; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biochemistry; Biomedical and Life Sciences; Biosynthesis; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Biology; Cell Culture; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Hypoxia - genetics; Chromatin; Cristae; Electron transfer; Electron transport chain; Gene expression; HeLa Cells; Hep G2 Cells; Hepatocellular carcinoma; Heterografts; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Immunology; Immunoprecipitation; Life Sciences; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mitochondria; Mitochondria - metabolism; Molecular modelling; Oxidative stress; Protein Kinases - genetics; Protein Kinases - metabolism; PTEN-induced putative kinase; Reactive oxygen species; Regulatory sequences; Therapeutic applications; Transcription; Transcriptomes; Transfection; Tumor Burden - genetics; Tumors

Hypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O 2 ) as the electron recipient, causes inefficient electron transfer through the electron transport chain at the mitochondria leading to accumulation of reactive oxygen species (ROS) which could create irreversible cellular d...