Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway - Kung-Chun Chiu, David; Pui-Wah Tse, Aki; Law, Cheuk-Ting; Ming-Jing Xu, Iris; Lee, Derek; Chen, Mengnuo; Kit-Ho Lai, Robin; Wai-Hin Yuen, Vincent; Wing-Sum Cheu, Jacinth; Wai-Hung Ho, Daniel; Wong, Chun-Ming; Zhang, Huafeng; et al. (Cell death & disease, 2019)
Keywords: 13; 13/1; 13/106; 13/109; 13/31; 13/51; 14; 14/28; 38; 631/67/2327; 631/80/86/2366; Animals; Antibodies; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biochemistry; Biomedical and Life Sciences; Biosynthesis; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Biology; Cell Culture; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Hypoxia - genetics; Chromatin; Cristae; Electron transfer; Electron transport chain; Gene expression; HeLa Cells; Hep G2 Cells; Hepatocellular carcinoma; Heterografts; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Immunology; Immunoprecipitation; Life Sciences; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mitochondria; Mitochondria - metabolism; Molecular modelling; Oxidative stress; Protein Kinases - genetics; Protein Kinases - metabolism; PTEN-induced putative kinase; Reactive oxygen species; Regulatory sequences; Therapeutic applications; Transcription; Transcriptomes; Transfection; Tumor Burden - genetics; Tumors