Food restriction increases NMDA receptor-mediated calcium—calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats

• Published in: Neuroscience Vol. 132; no. 4; pp. 1035 - 1043
• Main Authors: Haberny, S.L., Carr, K.D.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 2005; Elsevier
• Subjects: Activating Transcription Factor 2; Aminoacetonitrile - analogs & derivatives; Animals; Benzazepines - administration & dosage; Biological and medical sciences; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases - drug effects; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Cyclic AMP Response Element-Binding Protein - drug effects; Cyclic AMP Response Element-Binding Protein - metabolism; D1 receptor; Diet; Dizocilpine Maleate - pharmacology; Dopamine Agonists - administration & dosage; Excitatory Amino Acid Antagonists - pharmacology; food restriction; Fundamental and applied biological sciences. Psychology; Injections, Intraventricular; Male; MAP kinase; Mitogen-Activated Protein Kinase 1 - drug effects; Mitogen-Activated Protein Kinase 1 - metabolism; NMDA receptor; nucleus accumbens; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Phosphorylation; Protease Inhibitors - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 - drug effects; Receptors, Dopamine D1 - metabolism; Receptors, N-Methyl-D-Aspartate - drug effects; Receptors, N-Methyl-D-Aspartate - metabolism; Signal Transduction - physiology; Transcription Factors - drug effects; Transcription Factors - metabolism; Vertebrates: nervous system and sense organs; CaMK II; D1 receptor; TBST; food restriction; MAP kinase; nucleus accumbens; AL; FR; MAPK; ECL; PP1; NAc; MEK; CREB; ANOVA; NMDA receptor; DA; ERK; Phosphorylation; Extracellular signal-regulated protein kinase; Rat; Central nervous system; Glutamate receptor; Encephalon; Transcription factor CREB; Biological receptor; calmodulin-dependent protein kinase; Enzyme; Dopamine receptor; Transferases; Rodentia; D1 Dopamine receptor; Mitogen-activated protein kinase; Basal ganglion; Feeding; Nucleus accumbens; Vertebrata; Mammalia; Animal; Restricted diet; Ca

Biological drive states exert homeostatic control in part by increasing the reinforcing effects of environmental incentive stimuli. An apparent by-product of this adaptive response is the enhanced acquisition of drug self-administration behavior in food-restricted (FR) animals. While previous resear...