Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody

• Published in: Bone marrow transplantation (Basingstoke) Vol. 55; no. 7; pp. 1326 - 1336
• Main Authors: Chang, Ying-Jun, Xu, Lan-Ping, Wang, Yu, Zhang, Xiao-Hui, Chen, Huan, Chen, Yu-Hong, Wang, Feng-Rong, Han, Wei, Sun, Yu-Qian, Yan, Chen-Hua, Tang, Fei-Fei, Huo, Ming-Rui, Zhao, Xiang-Yu, Mo, Xiao-Dong, Liu, Kai-Yan, Huang, Xiao-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2020; Nature Publishing Group
• Subjects: 631/250/1854/2812; 631/250/1904; Antibodies; Antithymocyte globulin; Bone marrow; Cell Biology; Desensitization; Hematology; Histocompatibility antigen HLA; Immunotherapy; Internal Medicine; Medicine; Medicine & Public Health; Monoclonal antibodies; Patients; Public Health; Rituximab; Stem cell research; Stem cell transplantation; Stem Cells; Transplantation

To define the efficacy of a single dose of 375 mg/m 2 rituximab for DSA-positive patients with 2000 ≤ MFI < 10,000, we enrolled a prospective clinical cohort including patients with positive DSA treated with rituximab ( n  = 55, cohort A), a matched-pair cohort including cases with negative DSA (...