Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression - Chang, Yu-Chan; Chan, Yung-Chieh; Chang, Wei-Ming; Lin, Yuan-Feng; Yang, Chih-Jen; Su, Chia-Yi; Huang, Ming-Shyan; Wu, Alexander T.H.; Hsiao, Michael (Cancer letters, 2017)
Keywords: Aged; Aldolase A; Binding sites; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell Movement - drug effects; Data processing; Disease Progression; Disease-Free Survival; DNA microarrays; Enzyme Activation; Enzymes; Feedback; Female; Fructose-Bisphosphate Aldolase - genetics; Fructose-Bisphosphate Aldolase - metabolism; Gelatinase B; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Glycolysis; Hematology, Oncology and Palliative Medicine; HIF-1α stabilization; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Kaplan-Meier Estimate; Lactic acid; Liver cancer; Lung cancer; Lung cancer metastasis; Lung Neoplasms - drug therapy; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Malignancy; Matrix Metalloproteinase 9 - metabolism; Matrix Metalloproteinase Inhibitors - pharmacology; Metabolism; Metastases; Metastasis; Middle Aged; MMP9; Neoplasm Invasiveness; Non-small cell lung carcinoma; Proline-hydroxylase; Prolyl Hydroxylases - metabolism; Proportional Hazards Models; Protein Stability; Proteolysis; Retrospective Studies; RNA Interference; Signal Transduction; Survival; Therapeutic applications; Time Factors; Transfection; Tumors; United States--US; NSCLC; IHC; VEGF; Lung cancer metastasis; HIF-1α stabilization; HIF-1α; MMP9; PHD; EMT; HK2; shRNA; Aldolase A; IPA; ALDOA; Proline-hydroxylase; Hypoxia-inducible factor 1 alpha; Matrix Metallopeptidase 9; immunohistochemical; non-small cell lung cancer; Hexokinase 2; Epithelial-Mesenchymal Transition; short hairpin RNA; Vascular Endothelial Growth Factor; Ingenuity Pathway Analyses