Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease

• Published in: Experimental neurology Vol. 227; no. 2; pp. 296 - 301
• Main Authors: Suppa, A., Marsili, L., Belvisi, D., Conte, A., Iezzi, E., Modugno, N., Fabbrini, G., Berardelli, A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2011; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dyskinesias; Electromyography - methods; Female; Humans; Long-Term Potentiation - physiology; Male; Medical sciences; Middle Aged; Motor Cortex - physiology; Neurology; Neuronal Plasticity - physiology; Parkinson Disease - physiopathology; Parkinson's disease; Plasticity; Primary motor cortex; TMS; Transcranial Magnetic Stimulation - methods; Dyskinesias; PAS; Parkinson's disease; M1; TDCS; LTP; FDI; cTBS; STP; LIDs; ANOVA; Plasticity; NMDA; UPDRS; EMG; MEPs; TBS; AMT; UDysRS; iTBS; Primary motor cortex; PD; SNr; RMT; H&Y; MVC; TMS; LTD; rTMS; Nervous system diseases; Motor pathway; Central nervous system; Parkinson disease; Encephalon; Involuntary movement; Cerebral disorder; Motor cortex; Central nervous system disease; Degenerative disease; Neurological disorder; Extrapyramidal syndrome; Dyskinesia

In this study in patients with Parkinson's disease (PD), off and on dopaminergic therapy, with and without L-dopa-induced dyskinesias (LIDs), we tested intermittent theta-burst stimulation (iTBS), a technique currently used for non-invasively inducing long-term potentiation (LTP)-like plasticit...