Tetralogy of fallot, truncus arteriosus, abnormal myocardial architecture and anomalies of the aortic arch system induced by bis-diamine in rat fetuses

• Published in: Journal of the American College of Cardiology Vol. 21; no. 3; pp. 768 - 776
• Main Authors: Kuribayashi, Toshiro, Roberts, William C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1993; Elsevier Science
• Subjects: Abnormalities, Drug-Induced - pathology; Animals; Aorta, Thoracic - abnormalities; Biological and medical sciences; Cardiology. Vascular system; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Diamines - adverse effects; Female; Heart; Heart Defects, Congenital - chemically induced; Medical sciences; Myocardium - pathology; Pregnancy; Rats; Rats, Wistar; Tetralogy of Fallot - chemically induced; Truncus Arteriosus, Persistent - chemically induced; Pathophysiology; Rat; Rodentia; Cardiovascular disease; Congenital disease; Arteriopathy; Diamine; Vertebrata; Experimental disease; Mammalia; Malformation; Animal; Aortic arch; Heart disease; Fetus; Comparative study

Objectives. The aim of this study was to analyze the relation between anomalies of the heart and aortic arch arteries in near-term rat fetuses exposed to the chemical bis-diamine. Background. Bis-diamine is known to induce cardiovascular anomalies. Methods. Bis-diamine was given orally to normal pre...