The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

• Published in: Nature immunology Vol. 20; no. 7; pp. 879 - 889
• Main Authors: Zhou, Xiaofei, Yu, Jiayi, Cheng, Xuhong, Zhao, Baoyu, Manyam, Ganiraju C., Zhang, Li, Schluns, Kimberly, Li, Pingwei, Wang, Jing, Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2019; Nature Publishing Group
• Subjects: 631/250; 631/337; AKT protein; Animals; Antigens; Biomedical and Life Sciences; Biomedicine; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell activation; Cell Differentiation - genetics; Cell Differentiation - immunology; Clonal deletion; Cysteine Endopeptidases - deficiency; Cysteine Endopeptidases - metabolism; Cytotoxicity; Deubiquitinating Enzymes - metabolism; Disease Models, Animal; Energy Metabolism; Homeostasis; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunology; Infectious Diseases; Interleukin 15; Interleukin-15 - genetics; Interleukin-15 - metabolism; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Melanoma, Experimental; Mice; Mice, Transgenic; Natural killer cells; Protein Binding; Proto-Oncogene Proteins c-akt - metabolism; Receptors, Interleukin-15 - metabolism; Self Tolerance - genetics; Self Tolerance - immunology; Signal Transduction; T-Cell Antigen Receptor Specificity; Ubiquitin; Ubiquitination

CD8 + T cells and natural killer (NK) cells are central cellular components of immune responses against pathogens and cancer, which rely on interleukin (IL)-15 for homeostasis. Here we show that IL-15 also mediates homeostatic priming of CD8 + T cells for antigen-stimulated activation, which is cont...