The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming - Zhou, Xiaofei; Yu, Jiayi; Cheng, Xuhong; Zhao, Baoyu; Manyam, Ganiraju C.; Zhang, Li; Schluns, Kimberly; Li, Pingwei; Wang, Jing; Sun, Shao-Cong (Nature immunology, 2019)
Keywords: 631/250; 631/337; AKT protein; Animals; Antigens; Biomedical and Life Sciences; Biomedicine; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell activation; Cell Differentiation - genetics; Cell Differentiation - immunology; Clonal deletion; Cysteine Endopeptidases - deficiency; Cysteine Endopeptidases - metabolism; Cytotoxicity; Deubiquitinating Enzymes - metabolism; Disease Models, Animal; Energy Metabolism; Homeostasis; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunology; Infectious Diseases; Interleukin 15; Interleukin-15 - genetics; Interleukin-15 - metabolism; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Melanoma, Experimental; Mice; Mice, Transgenic; Natural killer cells; Protein Binding; Proto-Oncogene Proteins c-akt - metabolism; Receptors, Interleukin-15 - metabolism; Self Tolerance - genetics; Self Tolerance - immunology; Signal Transduction; T-Cell Antigen Receptor Specificity; Ubiquitin; Ubiquitination