The Immunomodulatory Effect of β-Glucan Depends on the Composition of the Gut Microbiota
This study aimed to elucidate the relationship between the immunomodulatory effects of β-glucan and the composition of gut microbiota in mice. The mice were fed a diet containing β-glucan for 3 weeks, and feces, blood, and tissues were then collected to analyze the immunomodulatory effect and gut mi...
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| Published in | Foods Vol. 12; no. 17; p. 3148 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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22.08.2023
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| Abstract | This study aimed to elucidate the relationship between the immunomodulatory effects of β-glucan and the composition of gut microbiota in mice. The mice were fed a diet containing β-glucan for 3 weeks, and feces, blood, and tissues were then collected to analyze the immunomodulatory effect and gut microbiota composition. Based on the results of the analysis of the expression level of immune-associated proteins, the high immunomodulatory effect group (HIE) and low immunomodulatory effect group (LIE) were categorized. Before the β-glucan diet, the proportions of the phylum Bacteroidota, family Muribaculaceae, and family Lactobacillaceae were significantly higher in HIE than in LIE. Furthermore, the genus Akkermansia was absent before the β-glucan diet and increased after β-glucan diet. These microbes had the ability to metabolize β-glucan or were beneficial to health. In conclusion, our findings demonstrate that variation in the composition of gut microbiota among individuals can result in varying expressions of β-glucan functionality. This outcome supports the notion that β-glucan may be metabolized through diverse pathways by gut microbes originally possessed by mice, subsequently producing various metabolites, such as short-chain fatty acids. Alternatively, the viscosity of the intestinal mucosa could be enhanced by β-glucan, potentially promoting the growth of certain bacteria (e.g., the genus Akkermansia). This study provides insights into the intricate interplay between β-glucan, gut microbiota, and immunomodulation. |
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| AbstractList | This study aimed to elucidate the relationship between the immunomodulatory effects of β-glucan and the composition of gut microbiota in mice. The mice were fed a diet containing β-glucan for 3 weeks, and feces, blood, and tissues were then collected to analyze the immunomodulatory effect and gut microbiota composition. Based on the results of the analysis of the expression level of immune-associated proteins, the high immunomodulatory effect group (HIE) and low immunomodulatory effect group (LIE) were categorized. Before the β-glucan diet, the proportions of the phylum Bacteroidota, family Muribaculaceae, and family Lactobacillaceae were significantly higher in HIE than in LIE. Furthermore, the genus Akkermansia was absent before the β-glucan diet and increased after β-glucan diet. These microbes had the ability to metabolize β-glucan or were beneficial to health. In conclusion, our findings demonstrate that variation in the composition of gut microbiota among individuals can result in varying expressions of β-glucan functionality. This outcome supports the notion that β-glucan may be metabolized through diverse pathways by gut microbes originally possessed by mice, subsequently producing various metabolites, such as short-chain fatty acids. Alternatively, the viscosity of the intestinal mucosa could be enhanced by β-glucan, potentially promoting the growth of certain bacteria (e.g., the genus Akkermansia). This study provides insights into the intricate interplay between β-glucan, gut microbiota, and immunomodulation. This study aimed to elucidate the relationship between the immunomodulatory effects of β-glucan and the composition of gut microbiota in mice. The mice were fed a diet containing β-glucan for 3 weeks, and feces, blood, and tissues were then collected to analyze the immunomodulatory effect and gut microbiota composition. Based on the results of the analysis of the expression level of immune-associated proteins, the high immunomodulatory effect group (HIE) and low immunomodulatory effect group (LIE) were categorized. Before the β-glucan diet, the proportions of the phylum Bacteroidota, family Muribaculaceae , and family Lactobacillaceae were significantly higher in HIE than in LIE. Furthermore, the genus Akkermansia was absent before the β-glucan diet and increased after β-glucan diet. These microbes had the ability to metabolize β-glucan or were beneficial to health. In conclusion, our findings demonstrate that variation in the composition of gut microbiota among individuals can result in varying expressions of β-glucan functionality. This outcome supports the notion that β-glucan may be metabolized through diverse pathways by gut microbes originally possessed by mice, subsequently producing various metabolites, such as short-chain fatty acids. Alternatively, the viscosity of the intestinal mucosa could be enhanced by β-glucan, potentially promoting the growth of certain bacteria (e.g., the genus Akkermansia ). This study provides insights into the intricate interplay between β-glucan, gut microbiota, and immunomodulation. |
| Audience | Academic |
| Author | Yoon, Yohan Lee, Jeeyeon Sung, Miseon |
| AuthorAffiliation | 1 Department of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, Republic of Korea; koof97@naver.com (M.S.); yyoon@sookmyung.ac.kr (Y.Y.) 3 Department of Food & Nutrition, Dong-eui University, Busan 47340, Republic of Korea 2 Risk Analysis Research Center, Sookmyung Women’s University, Seoul 04310, Republic of Korea |
| AuthorAffiliation_xml | – name: 2 Risk Analysis Research Center, Sookmyung Women’s University, Seoul 04310, Republic of Korea – name: 3 Department of Food & Nutrition, Dong-eui University, Busan 47340, Republic of Korea – name: 1 Department of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, Republic of Korea; koof97@naver.com (M.S.); yyoon@sookmyung.ac.kr (Y.Y.) |
| Author_xml | – sequence: 1 givenname: Miseon surname: Sung fullname: Sung, Miseon – sequence: 2 givenname: Yohan surname: Yoon fullname: Yoon, Yohan – sequence: 3 givenname: Jeeyeon surname: Lee fullname: Lee, Jeeyeon |
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| SubjectTerms | Abdomen Akkermansia Composition Diet Digestive system Fatty acids Feces Food Food science Functional foods & nutraceuticals Gastrointestinal tract Glucan gut microbiota composition health-functional food Immunomodulation immunomodulatory effect Intestinal microflora Lie groups Life sciences Metabolites Microbiota Microbiota (Symbiotic organisms) Microorganisms Pandemics Proteins β-Glucan |
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| Title | The Immunomodulatory Effect of β-Glucan Depends on the Composition of the Gut Microbiota |
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