Brain growth trajectories in mouse strains with central and peripheral serotonin differences: relevance to autism models

• Published in: Neuroscience Vol. 210; pp. 286 - 295
• Main Authors: Flood, Z.C, Engel, D.L.J, Simon, C.C, Negherbon, K.R, Murphy, L.J, Tamavimok, W, Anderson, G.M, Janušonis, S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 17.05.2012; Elsevier
• Subjects: 5-HT; Animal models; Animals; Autism; Autistic Disorder - genetics; Autistic Disorder - metabolism; Biological and medical sciences; Blood; Brain; Brain - growth & development; Brain - metabolism; brain growth; Central nervous system; Chromatography, High Pressure Liquid; Cortex (somatosensory); Disease Models, Animal; Female; Fundamental and applied biological sciences. Psychology; High-performance liquid chromatography; Hippocampus; Inbreeding; Litter; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nervous system; Neural networks; Neurology; Platelets; postnatal; Serotonin; Serotonin - genetics; Serotonin - metabolism; Single-nucleotide polymorphism; Social interactions; tryptophan hydroxylase; Vertebrates: nervous system and sense organs; postnatal; Tph2; ASD; hippocampus; REML; tryptophan hydroxylase 2; brain growth; 5-HT; autism spectrum disorder; restricted maximum likelihood estimation; blood; autism; Serotonin; Growth; Rodentia; Central nervous system; Encephalon; Vertebrata; Mammalia; Mouse; Animal; Neurotransmitter; Models; Hippocampus

Abstract The genetic heterogeneity of autism spectrum disorders (ASDs) suggests that their underlying neurobiology involves dysfunction at the neural network level. Understanding these neural networks will require a major collaborative effort and will depend on validated and widely accepted animal m...