Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

• Published in: Science signaling Vol. 9; no. 456; p. ra115
• Main Authors: Buskiewicz, Iwona A, Montgomery, Theresa, Yasewicz, Elizabeth C, Huber, Sally A, Murphy, Michael P, Hartley, Richard C, Kelly, Ryan, Crow, Mary K, Perl, Andras, Budd, Ralph C, Koenig, Andreas
• Format: Journal Article
• Language: English
• Published: United States 29.11.2016
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Amino Acid Substitution; Animals; Humans; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - metabolism; Lymphocytes - metabolism; Mice; Mitochondria - genetics; Mitochondria - metabolism; Mutation, Missense; Protein Multimerization; Reactive Oxygen Species - metabolism

The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during v...