Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism

• Published in: Progress in lipid research Vol. 47; no. 6; pp. 405 - 421
• Main Authors: Hunt, Mary C., Alexson, Stefan E.H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2008
• Subjects: Acyl-CoA; Acyl-CoA thioesterases; Acyltransferases; Acyltransferases - physiology; Alpha-oxidation; Animals; Beta-oxidation; Bile Acids and Salts - metabolism; Coenzyme A; Coenzyme A - metabolism; Dicarboxylic Acids - metabolism; Fatty Acid-Binding Proteins - physiology; Fatty Acids - metabolism; Humans; Lipid Metabolism - physiology; Medicin och hälsovetenskap; Mice; Omega-oxidation; Oxidation-Reduction; Peroxisomes; Peroxisomes - metabolism; Thiolester Hydrolases - physiology; Acyltransferases; Peroxisomes; Coenzyme A; Acyl-CoA; Acyl-CoA thioesterases; Alpha-oxidation; Beta-oxidation; Omega-oxidation

Peroxisomes are single membrane bound organelles present in almost all eukaryotic cells, and to date have been shown to contain approximately 60 identified enzymes involved in various metabolic pathways, including the oxidation of a variety of lipids. These lipids include very long-chain fatty acids...