Frequency-dependent selection in vaccine-associated pneumococcal population dynamics

• Published in: Nature ecology & evolution Vol. 1; no. 12; pp. 1950 - 1960
• Main Authors: Corander, Jukka, Fraser, Christophe, Gutmann, Michael U., Arnold, Brian, Hanage, William P., Bentley, Stephen D., Lipsitch, Marc, Croucher, Nicholas J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2017; Nature Publishing Group
• Subjects: 631/181/735; 631/326/325; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bayesian analysis; Biological and Physical Anthropology; Biomedical and Life Sciences; Computer simulation; Ecology; Evolutionary Biology; Evolutionary genetics; Frequency analysis; Frequency dependence; Frequency variation; Functional analysis; Gene frequency; Genes; Immunization; Life Sciences; Loci; Paleontology; Pneumococcal Vaccines - immunology; Population; Population Dynamics; Population structure; Populations; Selection, Genetic; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - immunology; Vaccines; Zoology

Many bacterial species are composed of multiple lineages distinguished by extensive variation in gene content. These often cocirculate in the same habitat, but the evolutionary and ecological processes that shape these complex populations are poorly understood. Addressing these questions is particul...