Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents
•Structural and geometrical features of mesoporous silica can benefit drug delivery.•Coupled with therapeutic agents, targeting for a host of cancers is possible.•Several shortcomings of existing therapies are shown to be overcome. Recently, remarkable efforts have focused on research towards enhanc...
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| Published in | Drug discovery today Vol. 25; no. 8; pp. 1513 - 1520 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2020
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| Online Access | Get full text |
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| Abstract | •Structural and geometrical features of mesoporous silica can benefit drug delivery.•Coupled with therapeutic agents, targeting for a host of cancers is possible.•Several shortcomings of existing therapies are shown to be overcome.
Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency. |
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| AbstractList | Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency. Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency. •Structural and geometrical features of mesoporous silica can benefit drug delivery.•Coupled with therapeutic agents, targeting for a host of cancers is possible.•Several shortcomings of existing therapies are shown to be overcome. Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency. |
| Author | Rasekh, Manoochehr Ahmad, Zeeshan Sayed, Elshaimaa G. Arshad, Muhammad S. Kucuk, Israfil Shepherd, Jennifer Wilson, Philippe B. Mehta, Prina Ruparelia, Ketan Singh, Neenu Fatouros, Dimitrios G. Alyassin, Yasmine Chang, Ming-Wei |
| Author_xml | – sequence: 1 givenname: Yasmine surname: Alyassin fullname: Alyassin, Yasmine organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 2 givenname: Elshaimaa G. surname: Sayed fullname: Sayed, Elshaimaa G. organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 3 givenname: Prina surname: Mehta fullname: Mehta, Prina organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 4 givenname: Ketan surname: Ruparelia fullname: Ruparelia, Ketan organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 5 givenname: Muhammad S. surname: Arshad fullname: Arshad, Muhammad S. organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 6 givenname: Manoochehr surname: Rasekh fullname: Rasekh, Manoochehr organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 7 givenname: Jennifer orcidid: 0000-0002-3790-0323 surname: Shepherd fullname: Shepherd, Jennifer organization: Department of Engineering, University of Leicester, Leicester, LE1 7RH, UK – sequence: 8 givenname: Israfil surname: Kucuk fullname: Kucuk, Israfil organization: Institute of Nanotechnology, Gebze Technical University, 41400 Gebze, Turkey – sequence: 9 givenname: Philippe B. orcidid: 0000-0003-0207-2246 surname: Wilson fullname: Wilson, Philippe B. organization: School of Animal, Rural and Environmental Sciences, Nottingham Trent University, Brackenhurst Campus, Southwell, NG25 0QF, UK – sequence: 10 givenname: Neenu surname: Singh fullname: Singh, Neenu organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK – sequence: 11 givenname: Ming-Wei orcidid: 0000-0002-0137-8895 surname: Chang fullname: Chang, Ming-Wei organization: Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown Campus, Newtownabbey, BT37 0QB, UK – sequence: 12 givenname: Dimitrios G. surname: Fatouros fullname: Fatouros, Dimitrios G. organization: Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, School of Pharmacy, 54124, Thessaloniki, Greece – sequence: 13 givenname: Zeeshan surname: Ahmad fullname: Ahmad, Zeeshan email: zahmad@dmu.ac.uk organization: Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32561300$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/adfm.201402755 10.1021/acsomega.8b02909 10.1016/j.msec.2016.11.040 10.3390/bioengineering4010003 10.3389/fpls.2016.01667 10.1002/chem.201703188 10.1016/j.actbio.2017.11.007 10.1016/j.msec.2017.11.040 10.1016/j.colsurfb.2016.10.049 10.1158/1538-7445.AM2018-4122 10.2147/IJN.S202210 10.1016/bs.acr.2017.11.003 10.1039/C4TB01030B 10.1038/srep45846 10.1088/1361-6528/aaff9e 10.3390/molecules23010047 10.20892/j.issn.2095-3941.2017.0052 10.1016/j.drudis.2017.10.022 10.1016/j.micromeso.2017.07.021 10.1002/anie.201104765 10.1016/j.jddst.2018.01.020 10.1016/j.ccr.2016.04.019 10.1002/jbm.a.36410 10.1002/cmdc.201800019 10.1039/C7CS00219J 10.1080/17425247.2019.1575806 10.3390/ijms20040929 10.1016/j.apsusc.2015.03.151 10.1016/j.colsurfb.2018.12.038 10.1016/j.ijpharm.2017.10.043 10.1016/j.jfda.2014.01.002 10.1016/j.colsurfb.2017.03.024 10.1016/j.jcis.2018.01.072 10.1002/adhm.201200116 10.1016/j.addr.2012.10.002 10.1016/j.biomaterials.2013.07.075 10.1021/nn103130q 10.1016/bs.enz.2018.07.005 10.1039/C8NR07667G 10.1186/s40580-019-0193-2 10.3109/1061186X.2011.622404 10.1016/j.ctrv.2015.10.010 10.1016/j.apsb.2018.01.007 10.1016/j.micromeso.2018.12.026 10.1021/acsami.5b11730 10.1016/j.addr.2013.09.001 10.1016/j.jconrel.2018.03.031 10.1016/j.nano.2015.10.018 10.1021/nn200809t 10.1016/j.ijbiomac.2018.09.058 10.1002/smll.201301926 10.1016/j.bios.2014.01.042 10.1016/j.ijpharm.2014.04.067 10.1021/acs.molpharmaceut.7b00109 10.1002/jbm.a.36770 10.3390/pharmaceutics11020077 10.1039/C7RA01028A 10.1080/17425247.2016.1211637 10.1039/C6BM00449K 10.1016/j.colsurfa.2019.03.030 10.1016/j.msec.2019.03.028 10.3390/nano7070189 10.1080/03639045.2019.1629688 10.1007/s12274-018-2078-9 10.1016/j.eururo.2019.01.049 10.2147/IJN.S213974 10.1016/S0928-0987(00)00114-7 10.2217/nnm-2018-0242 10.2174/0929867325666180501101044 10.1016/j.biopha.2019.109614 10.1208/s12249-017-0740-2 |
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| References | Naz (bib0100) 2019; 14 Popova (bib0205) 2018; 44 Tian (bib0245) 2019; 570 Watermann, Brieger (bib0135) 2017; 7 Gary-Bobo (bib0170) 2011; 50 Mo (bib0350) 2016; 8 Feng (bib0180) 2016; 319 Singh (bib0250) 2016; 7 Li (bib0155) 2012; 1 Sayed (bib0275) 2018; 278 Cui (bib0345) 2013; 34 Sayed (bib0010) 2017; 18 Chen (bib0160) 2018; 11 Vallet-Regí (bib0015) 2017; 23 Du, X (bib0230) 2015; 345 Vallet-Regí (bib0075) 2018; 23 Amreddy, Babu, Muralidharan, Panneerselvam, Srivastava, Ahmed (bib0200) 2018; 137 Wong (bib0215) 2017; 23 Xiao (bib0150) 2014; 10 Zhu (bib0185) 2014; 22 Poonia (bib0130) 2017; 23 Perera (bib0300) 2019; 77 Mehta (bib0360) 2019; 2 Gayam, Wu (bib0175) 2014; 2 Du, Fu, Ren, Li, Guo (bib0305) 2020; 121 Kim (bib0220) 2011; 5 Taratula (bib0320) 2011; 19 Wang (bib0290) 2019; 45 Krishna, Mayer (bib0265) 2000; 11 Li (bib0325) 2017; 5 Luo (bib0085) 2019; 100 Maeda (bib0120) 2013; 65 Aquib, Farooq, Banerjee, Akhtar, Filli, Boakye-Yiadom, Kesse, Raza, Maviah, Mavlyanova, Wang (bib0190) 2019; 107 Yang, Yu (bib0125) 2016; 12 Kesse (bib0340) 2019; 11 Samykutty (bib0065) 2018; 78 Dilnawaz (bib0110) 2018; 26 Meng (bib0140) 2011; 5 Gisbert-Garzarán (bib0225) 2017; 4 Kumar (bib0335) 2017; 150 Fang (bib0080) 2019; 14 Lin (bib0105) 2018; 536 Vallet-Regi (bib0355) 2018; 43 Ricci (bib0050) 2018; 516 Jia, Yang, Wang, Chen, Yuan, Chen (bib0195) 2018; 13 Xin (bib0235) 2017; 14 Tian (bib0330) 2017; 154 Castillo (bib0005) 2017; 14 Rehman (bib0055) 2017; 72 Wen (bib0210) 2017; 46 Li (bib0025) 2019; 16 Liu (bib0310) 2019; 175 Montalvo-Quiros (bib0045) 2019; 11 Chen (bib0060) 2019; 122 Rivero-Buceta (bib0315) 2019; 4 Chi (bib0285) 2019; 30 Bhavsar (bib0295) 2019; 279 Martínez-Carmona (bib0070) 2018; 65 Rasekh (bib0365) 2017; 14 Zhang (bib0090) 2019; 14 Wong (bib0280) 2017; 7 Castillo, Vallet-Regí (bib0035) 2019; 20 Frederiks (bib0255) 2015; 41 Palanikumar (bib0240) 2015; 25 Fang (bib0165) 2014; 57 Gonzalez (bib0040) 2018; 256 Monem (bib0145) 2014; 470 Navya (bib0030) 2019; 6 Zhao (bib0095) 2018; 84 Vilaça (bib0020) 2017; 7 Zhou (bib0115) 2018; 8 Kirtane (bib0270) 2013; 65 Olov (bib0260) 2018; 106 Yang (10.1016/j.drudis.2020.06.006_bib0125) 2016; 12 Liu (10.1016/j.drudis.2020.06.006_bib0310) 2019; 175 Rasekh (10.1016/j.drudis.2020.06.006_bib0365) 2017; 14 Vallet-Regí (10.1016/j.drudis.2020.06.006_bib0075) 2018; 23 Meng (10.1016/j.drudis.2020.06.006_bib0140) 2011; 5 Navya (10.1016/j.drudis.2020.06.006_bib0030) 2019; 6 Sayed (10.1016/j.drudis.2020.06.006_bib0010) 2017; 18 Wong (10.1016/j.drudis.2020.06.006_bib0280) 2017; 7 Xin (10.1016/j.drudis.2020.06.006_bib0235) 2017; 14 Du (10.1016/j.drudis.2020.06.006_bib0230) 2015; 345 Gisbert-Garzarán (10.1016/j.drudis.2020.06.006_bib0225) 2017; 4 Tian (10.1016/j.drudis.2020.06.006_bib0245) 2019; 570 Gary-Bobo (10.1016/j.drudis.2020.06.006_bib0170) 2011; 50 Gonzalez (10.1016/j.drudis.2020.06.006_bib0040) 2018; 256 Castillo (10.1016/j.drudis.2020.06.006_bib0035) 2019; 20 Kesse (10.1016/j.drudis.2020.06.006_bib0340) 2019; 11 Kim (10.1016/j.drudis.2020.06.006_bib0220) 2011; 5 Luo (10.1016/j.drudis.2020.06.006_bib0085) 2019; 100 Vallet-Regí (10.1016/j.drudis.2020.06.006_bib0015) 2017; 23 Feng (10.1016/j.drudis.2020.06.006_bib0180) 2016; 319 Wang (10.1016/j.drudis.2020.06.006_bib0290) 2019; 45 Popova (10.1016/j.drudis.2020.06.006_bib0205) 2018; 44 Zhou (10.1016/j.drudis.2020.06.006_bib0115) 2018; 8 Zhang (10.1016/j.drudis.2020.06.006_bib0090) 2019; 14 Taratula (10.1016/j.drudis.2020.06.006_bib0320) 2011; 19 Fang (10.1016/j.drudis.2020.06.006_bib0080) 2019; 14 Watermann (10.1016/j.drudis.2020.06.006_bib0135) 2017; 7 Kirtane (10.1016/j.drudis.2020.06.006_bib0270) 2013; 65 Chen (10.1016/j.drudis.2020.06.006_bib0060) 2019; 122 Chen (10.1016/j.drudis.2020.06.006_bib0160) 2018; 11 Aquib (10.1016/j.drudis.2020.06.006_bib0190) 2019; 107 Amreddy (10.1016/j.drudis.2020.06.006_bib0200) 2018; 137 Palanikumar (10.1016/j.drudis.2020.06.006_bib0240) 2015; 25 Mehta (10.1016/j.drudis.2020.06.006_bib0360) 2019; 2 Li (10.1016/j.drudis.2020.06.006_bib0155) 2012; 1 Vallet-Regi (10.1016/j.drudis.2020.06.006_bib0355) 2018; 43 Lin (10.1016/j.drudis.2020.06.006_bib0105) 2018; 536 Ricci (10.1016/j.drudis.2020.06.006_bib0050) 2018; 516 Jia (10.1016/j.drudis.2020.06.006_bib0195) 2018; 13 Singh (10.1016/j.drudis.2020.06.006_bib0250) 2016; 7 Vilaça (10.1016/j.drudis.2020.06.006_bib0020) 2017; 7 Perera (10.1016/j.drudis.2020.06.006_bib0300) 2019; 77 Samykutty (10.1016/j.drudis.2020.06.006_bib0065) 2018; 78 Xiao (10.1016/j.drudis.2020.06.006_bib0150) 2014; 10 Rehman (10.1016/j.drudis.2020.06.006_bib0055) 2017; 72 Chi (10.1016/j.drudis.2020.06.006_bib0285) 2019; 30 Du (10.1016/j.drudis.2020.06.006_bib0305) 2020; 121 Poonia (10.1016/j.drudis.2020.06.006_bib0130) 2017; 23 Montalvo-Quiros (10.1016/j.drudis.2020.06.006_bib0045) 2019; 11 Tian (10.1016/j.drudis.2020.06.006_bib0330) 2017; 154 Li (10.1016/j.drudis.2020.06.006_bib0325) 2017; 5 Mo (10.1016/j.drudis.2020.06.006_bib0350) 2016; 8 Wong (10.1016/j.drudis.2020.06.006_bib0215) 2017; 23 Wen (10.1016/j.drudis.2020.06.006_bib0210) 2017; 46 Sayed (10.1016/j.drudis.2020.06.006_bib0275) 2018; 278 Zhu (10.1016/j.drudis.2020.06.006_bib0185) 2014; 22 Krishna (10.1016/j.drudis.2020.06.006_bib0265) 2000; 11 Zhao (10.1016/j.drudis.2020.06.006_bib0095) 2018; 84 Naz (10.1016/j.drudis.2020.06.006_bib0100) 2019; 14 Bhavsar (10.1016/j.drudis.2020.06.006_bib0295) 2019; 279 Martínez-Carmona (10.1016/j.drudis.2020.06.006_bib0070) 2018; 65 Dilnawaz (10.1016/j.drudis.2020.06.006_bib0110) 2018; 26 Gayam (10.1016/j.drudis.2020.06.006_bib0175) 2014; 2 Cui (10.1016/j.drudis.2020.06.006_bib0345) 2013; 34 Monem (10.1016/j.drudis.2020.06.006_bib0145) 2014; 470 Fang (10.1016/j.drudis.2020.06.006_bib0165) 2014; 57 Frederiks (10.1016/j.drudis.2020.06.006_bib0255) 2015; 41 Castillo (10.1016/j.drudis.2020.06.006_bib0005) 2017; 14 Olov (10.1016/j.drudis.2020.06.006_bib0260) 2018; 106 Li (10.1016/j.drudis.2020.06.006_bib0025) 2019; 16 Kumar (10.1016/j.drudis.2020.06.006_bib0335) 2017; 150 Maeda (10.1016/j.drudis.2020.06.006_bib0120) 2013; 65 Rivero-Buceta (10.1016/j.drudis.2020.06.006_bib0315) 2019; 4 |
| References_xml | – volume: 516 start-page: 484 year: 2018 end-page: 497 ident: bib0050 article-title: Hyaluronated mesoporous silica nanoparticles for active targeting: Influence of conjugation method and hyaluronic acid molecular weight on the nanovector properties publication-title: J. Colloid Interface Sci. – volume: 45 start-page: 1487 year: 2019 end-page: 1495 ident: bib0290 article-title: Combined chemo/photothermal therapy based on mesoporous silica-au core-shell nanoparticles for hepatocellular carcinoma treatment publication-title: Drug Dev. Ind. Pharm. – volume: 65 start-page: 393 year: 2018 end-page: 404 ident: bib0070 article-title: Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment publication-title: Acta Biomater. – volume: 22 start-page: 18 year: 2014 end-page: 28 ident: bib0185 article-title: Cell microenvironment stimuli-responsive controlled-release delivery systems based on mesoporous silica nanoparticles publication-title: J. Food Drug Anal. – volume: 11 start-page: 265 year: 2000 end-page: 283 ident: bib0265 article-title: Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs publication-title: Eur. J. Pharm. Sci. – volume: 11 start-page: 4890 year: 2018 end-page: 4904 ident: bib0160 article-title: General synthesis of silica-based yolk/shell hybrid nanomaterials and publication-title: Nano Res. – volume: 8 start-page: 6811 year: 2016 end-page: 6825 ident: bib0350 article-title: Tailoring particle size of mesoporous silica nanosystem to antagonize glioblastoma and overcome blood–brain barrier publication-title: ACS Appl. Mater. Interfaces – volume: 279 start-page: 107 year: 2019 end-page: 116 ident: bib0295 article-title: Formulation and development of smart pH responsive mesoporous silica nanoparticles for breast cancer targeted delivery of anastrozole: publication-title: Microporous Mesoporous Mater. – volume: 11 start-page: 77 year: 2019 ident: bib0340 article-title: Mesoporous silica nanomaterials: versatile nanocarriers for cancer theranostics and drug and gene delivery publication-title: Pharmaceutics – volume: 77 start-page: 403 year: 2019 end-page: 417 ident: bib0300 article-title: Gallium-68 prostate-specific membrane antigen positron emission tomography in advanced prostate cancer—updated diagnostic utility, sensitivity, specificity, and distribution of prostate-specific membrane antigen-avid lesions: a systematic review and meta-analysis publication-title: Eur. Urol. – volume: 122 start-page: 1090 year: 2019 end-page: 1099 ident: bib0060 article-title: A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer publication-title: Int. J. Biol. Macromol. – volume: 1 start-page: 567 year: 2012 end-page: 572 ident: bib0155 article-title: Polyvalent mesoporous silica nanoparticle‐aptamer bioconjugates target breast cancer cells publication-title: Adv. Healthc. Mater. – volume: 319 start-page: 86 year: 2016 end-page: 109 ident: bib0180 article-title: The application of mesoporous silica nanoparticle family in cancer theranostics publication-title: Coord. Chem. Rev. – volume: 23 start-page: 47 year: 2018 ident: bib0075 article-title: Mesoporous silica nanoparticles for drug delivery: current insights publication-title: Molecules – volume: 23 start-page: 47 year: 2017 ident: bib0015 article-title: Mesoporous silica nanoparticles for drug delivery: current insights publication-title: Molecules – volume: 256 start-page: 251 year: 2018 end-page: 265 ident: bib0040 article-title: Comparative study of two silica mesoporous materials (SBA-16 and SBA-15) modified with a hydroxyapatite layer for clindamycin controlled delivery publication-title: Microporous Mesoporous Mater. – volume: 14 start-page: 5785 year: 2019 ident: bib0080 article-title: Hyaluronic acid-modified mesoporous silica–coated superparamagnetic Fe3O4 nanoparticles for targeted drug delivery publication-title: Int. J. Nanomed. – volume: 65 start-page: 71 year: 2013 end-page: 79 ident: bib0120 article-title: The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging publication-title: Adv. Drug Deliv. Rev. – volume: 12 start-page: 317 year: 2016 end-page: 332 ident: bib0125 article-title: Advances in silica based nanoparticles for targeted cancer therapy publication-title: Nanomedicine – volume: 345 start-page: 90 year: 2015 end-page: 98 ident: bib0230 article-title: Layer-by-layer engineering fluorescent polyelectrolyte coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release publication-title: Appl. Surf. Sci. – volume: 536 start-page: 272 year: 2018 end-page: 282 ident: bib0105 article-title: PEGylated lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: Design, characterization and its cytotoxic effect publication-title: Int. J. Pharm. – volume: 23 start-page: 315 year: 2017 end-page: 322 ident: bib0130 article-title: Mesoporous silica nanoparticles: a smart nanosystem for management of breast cancer publication-title: Drug Discov. Today – volume: 50 start-page: 11425 year: 2011 end-page: 11429 ident: bib0170 article-title: Mannose‐functionalized mesoporous silica nanoparticles for efficient two‐photon photodynamic therapy of solid tumors publication-title: Angew. Chem. Int. Ed. – volume: 5 start-page: 77 year: 2017 end-page: 88 ident: bib0325 article-title: Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment publication-title: Biomater. Sci. – volume: 43 start-page: 101 year: 2018 end-page: 122 ident: bib0355 article-title: Controlled release with emphasis on ultrasound-induced release publication-title: Enzymes – volume: 7 start-page: 1667 year: 2016 ident: bib0250 article-title: Lead phytochemicals for anticancer drug development publication-title: Front. Plant Sci. – volume: 5 start-page: 3568 year: 2011 end-page: 3576 ident: bib0220 article-title: Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery publication-title: ACS Nano – volume: 175 start-page: 477 year: 2019 end-page: 486 ident: bib0310 article-title: Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment publication-title: Colloids Surf. B Biointerfaces – volume: 107 start-page: 2643 year: 2019 end-page: 2666 ident: bib0190 article-title: Targeted and stimuli-responsive mesoporous silica nanoparticles for drug delivery and theranostic use publication-title: J Biomed Mat Res A – volume: 137 start-page: 115 year: 2018 end-page: 170 ident: bib0200 article-title: Recent advances in nanoparticle-based cancer drug and gene delivery publication-title: Adv. Cancer Res. – volume: 23 start-page: 16505 year: 2017 end-page: 16515 ident: bib0215 article-title: Encapsulating pH‐responsive doxorubicin–phthalocyanine conjugates in mesoporous silica nanoparticles for combined photodynamic therapy and controlled chemotherapy publication-title: Chemistry – volume: 570 start-page: 386 year: 2019 end-page: 395 ident: bib0245 article-title: Hollow mesoporous carbon modified with cRGD peptide nanoplatform for targeted drug delivery and chemo-photothermal therapy of prostatic carcinoma publication-title: Colloids Surf. A Physicochem. Eng. Asp. – volume: 19 start-page: 900 year: 2011 end-page: 914 ident: bib0320 article-title: Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA publication-title: J. Drug Target. – volume: 470 start-page: 1 year: 2014 end-page: 7 ident: bib0145 article-title: Mesoporous silica coated gold nanorods loaded doxorubicin for combined chemo-photothermal therapy publication-title: Int. J. Pharm. – volume: 7 start-page: 189 year: 2017 ident: bib0135 article-title: Mesoporous silica nanoparticles as drug delivery vehicles in cancer publication-title: Nanomaterials – volume: 13 start-page: 400 year: 2018 end-page: 405 ident: bib0195 article-title: Hollow mesoporous silica@metal-organic framework and its applications for pH-responsive doxorubicin drug delivery publication-title: ChemMedChem – volume: 34 start-page: 8511 year: 2013 end-page: 8520 ident: bib0345 article-title: Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment publication-title: Biomaterials – volume: 65 start-page: 1731 year: 2013 end-page: 1747 ident: bib0270 article-title: Exploiting nanotechnology to overcome tumor drug resistance: challenges and opportunities publication-title: Adv. Drug Deliv. Rev. – volume: 25 start-page: 957 year: 2015 end-page: 965 ident: bib0240 article-title: Noncovalent polymer‐gatekeeper in mesoporous silica nanoparticles as a targeted drug delivery platform publication-title: Adv. Funct. Mater. – volume: 154 start-page: 287 year: 2017 end-page: 296 ident: bib0330 article-title: pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin publication-title: Colloids Surf. B Biointerfaces – volume: 278 start-page: 142 year: 2018 end-page: 155 ident: bib0275 article-title: Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: publication-title: J. Control. Release – volume: 26 start-page: 5745 year: 2018 end-page: 5763 ident: bib0110 article-title: Multifunctional mesoporous silica nanoparticles for cancer therapy and imaging publication-title: Curr. Med. Chem. – volume: 16 start-page: 219 year: 2019 end-page: 237 ident: bib0025 article-title: Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery publication-title: Expert Opin. Drug Deliv. – volume: 14 start-page: 2533 year: 2019 ident: bib0100 article-title: Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage–targeted drug delivery publication-title: Int. J. Nanomed. – volume: 14 start-page: 228 year: 2017 ident: bib0235 article-title: Recent progress on nanoparticle-based drug delivery systems for cancer therapy publication-title: Cancer Biol. Med. – volume: 72 start-page: 34 year: 2017 end-page: 41 ident: bib0055 article-title: Amine bridges grafted mesoporous silica, as a prolonged/controlled drug release system for the enhanced therapeutic effect of short life drugs publication-title: Mater. Sci. Eng. C – volume: 84 start-page: 108 year: 2018 end-page: 117 ident: bib0095 article-title: TPGS functionalized mesoporous silica nanoparticles for anticancer drug delivery to overcome multidrug resistance publication-title: Mater. Sci. Eng. C – volume: 44 start-page: 415 year: 2018 end-page: 420 ident: bib0205 article-title: Polymer-coated mesoporous silica nanoparticles for controlled release of the prodrug sulfasalazine publication-title: J. Drug Deliv. Sci. Technol. – volume: 150 start-page: 352 year: 2017 end-page: 361 ident: bib0335 article-title: Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping publication-title: Colloids Surf. B Biointerfaces – volume: 7 start-page: 13104 year: 2017 end-page: 13111 ident: bib0020 article-title: Comparison of different silica microporous structures as drug delivery systems for publication-title: RSC Adv. – volume: 14 start-page: 229 year: 2017 end-page: 243 ident: bib0005 article-title: Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer publication-title: Expert Opin. Drug Deliv. – volume: 121 start-page: 109614 year: 2020 ident: bib0305 article-title: PSA targeted dual-modality manganese oxide-mesoporous silica nanoparticles for prostate cancer imaging publication-title: Biomed. Pharmacother. – volume: 57 start-page: 10 year: 2014 end-page: 15 ident: bib0165 article-title: pH-controllable drug carrier with SERS activity for targeting cancer cells publication-title: Biosens. Bioelectron. – volume: 106 start-page: 2272 year: 2018 end-page: 2283 ident: bib0260 article-title: Combinational drug delivery using nanocarriers for breast cancer treatments: a review publication-title: J. Biomed. Mater. Res. A – volume: 41 start-page: 935 year: 2015 end-page: 950 ident: bib0255 article-title: Genetic polymorphisms and paclitaxel-or docetaxel-induced toxicities: a systematic review publication-title: Cancer Treat. Rev. – volume: 11 start-page: 4531 year: 2019 end-page: 4545 ident: bib0045 article-title: Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: Insights into the action mechanisms using quantitative proteomics publication-title: Nanoscale – volume: 2 start-page: 7009 year: 2014 end-page: 7016 ident: bib0175 article-title: Redox responsive pd (II) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system publication-title: J. Mater. Chem. B – volume: 18 start-page: 1507 year: 2017 end-page: 1525 ident: bib0010 article-title: Porous inorganic drug delivery systems—a review publication-title: AAPS PharmSciTech – volume: 4 start-page: 1281 year: 2019 end-page: 1291 ident: bib0315 article-title: PSMA-targeted mesoporous silica nanoparticles for selective intracellular delivery of docetaxel in prostate cancer cells publication-title: ACS Omega – volume: 10 start-page: 591 year: 2014 end-page: 598 ident: bib0150 article-title: A dual‐responsive mesoporous silica nanoparticle for tumor-triggered targeting drug delivery publication-title: Small – volume: 7 start-page: 45846 year: 2017 ident: bib0280 article-title: International incidence and mortality trends of liver cancer: a global profile publication-title: Sci. Rep. – volume: 30 start-page: 175101 year: 2019 ident: bib0285 article-title: Targeted arsenite-loaded magnetic multifunctional nanoparticles for treatment of hepatocellular carcinoma publication-title: Nanotechnology – volume: 8 start-page: 165 year: 2018 end-page: 177 ident: bib0115 article-title: Mesoporous silica nanoparticles for drug and gene delivery publication-title: Acta Pharm. Sin. B – volume: 46 start-page: 6024 year: 2017 end-page: 6045 ident: bib0210 article-title: Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems publication-title: Chem. Soc. Rev. – volume: 20 start-page: 929 year: 2019 ident: bib0035 article-title: Functional mesoporous silica nanocomposites: biomedical applications and biosafety publication-title: Int. J. Mol. Sci. – volume: 78 start-page: 4122 year: 2018 ident: bib0065 article-title: Acidic tumor microenvironment targeted wormhole-shaped mesoporous silica nanoparticles to detect ovarian cancer by multispectral optoacoustic tomography publication-title: Cancer Res. – volume: 100 start-page: 855 year: 2019 end-page: 861 ident: bib0085 article-title: Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery publication-title: Mater. Sci. Eng. C – volume: 14 start-page: 2010 year: 2017 end-page: 2023 ident: bib0365 article-title: Facile preparation of drug-loaded tristearin encapsulated superparamagnetic iron oxide nanoparticles using coaxial electrospray processing publication-title: Mol. Pharm. – volume: 14 start-page: 1443 year: 2019 end-page: 1454 ident: bib0090 article-title: Mesoporous gold nanoparticles for photothermal controlled anticancer drug delivery publication-title: Nanomedicine – volume: 2 year: 2019 ident: bib0360 article-title: Broad scale and structure fabrication of healthcare materials for drug and emerging therapies via electrohydrodynamic techniques publication-title: Adv. Ther. – volume: 5 start-page: 4131 year: 2011 end-page: 4144 ident: bib0140 article-title: Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model publication-title: ACS Nano – volume: 4 start-page: 3 year: 2017 ident: bib0225 article-title: pH-responsive mesoporous silica and carbon nanoparticles for drug delivery publication-title: Bioengineering – volume: 6 start-page: 23 year: 2019 ident: bib0030 article-title: Current trends and challenges in cancer management and therapy using designer nanomaterials publication-title: Nano Converg. – volume: 25 start-page: 957 year: 2015 ident: 10.1016/j.drudis.2020.06.006_bib0240 article-title: Noncovalent polymer‐gatekeeper in mesoporous silica nanoparticles as a targeted drug delivery platform publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201402755 – volume: 4 start-page: 1281 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0315 article-title: PSMA-targeted mesoporous silica nanoparticles for selective intracellular delivery of docetaxel in prostate cancer cells publication-title: ACS Omega doi: 10.1021/acsomega.8b02909 – volume: 72 start-page: 34 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0055 article-title: Amine bridges grafted mesoporous silica, as a prolonged/controlled drug release system for the enhanced therapeutic effect of short life drugs publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2016.11.040 – volume: 4 start-page: 3 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0225 article-title: pH-responsive mesoporous silica and carbon nanoparticles for drug delivery publication-title: Bioengineering doi: 10.3390/bioengineering4010003 – volume: 7 start-page: 1667 year: 2016 ident: 10.1016/j.drudis.2020.06.006_bib0250 article-title: Lead phytochemicals for anticancer drug development publication-title: Front. Plant Sci. doi: 10.3389/fpls.2016.01667 – volume: 23 start-page: 16505 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0215 article-title: Encapsulating pH‐responsive doxorubicin–phthalocyanine conjugates in mesoporous silica nanoparticles for combined photodynamic therapy and controlled chemotherapy publication-title: Chemistry doi: 10.1002/chem.201703188 – volume: 65 start-page: 393 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0070 article-title: Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.11.007 – volume: 84 start-page: 108 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0095 article-title: TPGS functionalized mesoporous silica nanoparticles for anticancer drug delivery to overcome multidrug resistance publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2017.11.040 – volume: 150 start-page: 352 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0335 article-title: Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2016.10.049 – volume: 78 start-page: 4122 issue: Suppl year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0065 article-title: Acidic tumor microenvironment targeted wormhole-shaped mesoporous silica nanoparticles to detect ovarian cancer by multispectral optoacoustic tomography publication-title: Cancer Res. doi: 10.1158/1538-7445.AM2018-4122 – volume: 14 start-page: 2533 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0100 article-title: Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage–targeted drug delivery publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S202210 – volume: 137 start-page: 115 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0200 article-title: Recent advances in nanoparticle-based cancer drug and gene delivery publication-title: Adv. Cancer Res. doi: 10.1016/bs.acr.2017.11.003 – volume: 2 start-page: 7009 year: 2014 ident: 10.1016/j.drudis.2020.06.006_bib0175 article-title: Redox responsive pd (II) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system publication-title: J. Mater. Chem. B doi: 10.1039/C4TB01030B – volume: 7 start-page: 45846 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0280 article-title: International incidence and mortality trends of liver cancer: a global profile publication-title: Sci. Rep. doi: 10.1038/srep45846 – volume: 30 start-page: 175101 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0285 article-title: Targeted arsenite-loaded magnetic multifunctional nanoparticles for treatment of hepatocellular carcinoma publication-title: Nanotechnology doi: 10.1088/1361-6528/aaff9e – volume: 23 start-page: 47 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0075 article-title: Mesoporous silica nanoparticles for drug delivery: current insights publication-title: Molecules doi: 10.3390/molecules23010047 – volume: 14 start-page: 228 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0235 article-title: Recent progress on nanoparticle-based drug delivery systems for cancer therapy publication-title: Cancer Biol. Med. doi: 10.20892/j.issn.2095-3941.2017.0052 – volume: 23 start-page: 315 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0130 article-title: Mesoporous silica nanoparticles: a smart nanosystem for management of breast cancer publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2017.10.022 – volume: 2 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0360 article-title: Broad scale and structure fabrication of healthcare materials for drug and emerging therapies via electrohydrodynamic techniques publication-title: Adv. Ther. – volume: 256 start-page: 251 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0040 article-title: Comparative study of two silica mesoporous materials (SBA-16 and SBA-15) modified with a hydroxyapatite layer for clindamycin controlled delivery publication-title: Microporous Mesoporous Mater. doi: 10.1016/j.micromeso.2017.07.021 – volume: 50 start-page: 11425 year: 2011 ident: 10.1016/j.drudis.2020.06.006_bib0170 article-title: Mannose‐functionalized mesoporous silica nanoparticles for efficient two‐photon photodynamic therapy of solid tumors publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201104765 – volume: 44 start-page: 415 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0205 article-title: Polymer-coated mesoporous silica nanoparticles for controlled release of the prodrug sulfasalazine publication-title: J. Drug Deliv. Sci. Technol. doi: 10.1016/j.jddst.2018.01.020 – volume: 319 start-page: 86 year: 2016 ident: 10.1016/j.drudis.2020.06.006_bib0180 article-title: The application of mesoporous silica nanoparticle family in cancer theranostics publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2016.04.019 – volume: 106 start-page: 2272 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0260 article-title: Combinational drug delivery using nanocarriers for breast cancer treatments: a review publication-title: J. Biomed. Mater. Res. A doi: 10.1002/jbm.a.36410 – volume: 13 start-page: 400 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0195 article-title: Hollow mesoporous silica@metal-organic framework and its applications for pH-responsive doxorubicin drug delivery publication-title: ChemMedChem doi: 10.1002/cmdc.201800019 – volume: 46 start-page: 6024 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0210 article-title: Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems publication-title: Chem. Soc. Rev. doi: 10.1039/C7CS00219J – volume: 16 start-page: 219 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0025 article-title: Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery publication-title: Expert Opin. Drug Deliv. doi: 10.1080/17425247.2019.1575806 – volume: 20 start-page: 929 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0035 article-title: Functional mesoporous silica nanocomposites: biomedical applications and biosafety publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20040929 – volume: 345 start-page: 90 year: 2015 ident: 10.1016/j.drudis.2020.06.006_bib0230 article-title: Layer-by-layer engineering fluorescent polyelectrolyte coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release publication-title: Appl. Surf. Sci. doi: 10.1016/j.apsusc.2015.03.151 – volume: 175 start-page: 477 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0310 article-title: Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2018.12.038 – volume: 536 start-page: 272 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0105 article-title: PEGylated lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: Design, characterization and its cytotoxic effect publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.10.043 – volume: 22 start-page: 18 year: 2014 ident: 10.1016/j.drudis.2020.06.006_bib0185 article-title: Cell microenvironment stimuli-responsive controlled-release delivery systems based on mesoporous silica nanoparticles publication-title: J. Food Drug Anal. doi: 10.1016/j.jfda.2014.01.002 – volume: 154 start-page: 287 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0330 article-title: pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2017.03.024 – volume: 516 start-page: 484 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0050 article-title: Hyaluronated mesoporous silica nanoparticles for active targeting: Influence of conjugation method and hyaluronic acid molecular weight on the nanovector properties publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2018.01.072 – volume: 1 start-page: 567 year: 2012 ident: 10.1016/j.drudis.2020.06.006_bib0155 article-title: Polyvalent mesoporous silica nanoparticle‐aptamer bioconjugates target breast cancer cells publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201200116 – volume: 65 start-page: 71 year: 2013 ident: 10.1016/j.drudis.2020.06.006_bib0120 article-title: The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2012.10.002 – volume: 23 start-page: 47 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0015 article-title: Mesoporous silica nanoparticles for drug delivery: current insights publication-title: Molecules doi: 10.3390/molecules23010047 – volume: 34 start-page: 8511 issue: 33 year: 2013 ident: 10.1016/j.drudis.2020.06.006_bib0345 article-title: Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.07.075 – volume: 5 start-page: 3568 year: 2011 ident: 10.1016/j.drudis.2020.06.006_bib0220 article-title: Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery publication-title: ACS Nano doi: 10.1021/nn103130q – volume: 43 start-page: 101 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0355 article-title: Controlled release with emphasis on ultrasound-induced release publication-title: Enzymes doi: 10.1016/bs.enz.2018.07.005 – volume: 11 start-page: 4531 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0045 article-title: Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: Insights into the action mechanisms using quantitative proteomics publication-title: Nanoscale doi: 10.1039/C8NR07667G – volume: 6 start-page: 23 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0030 article-title: Current trends and challenges in cancer management and therapy using designer nanomaterials publication-title: Nano Converg. doi: 10.1186/s40580-019-0193-2 – volume: 19 start-page: 900 year: 2011 ident: 10.1016/j.drudis.2020.06.006_bib0320 article-title: Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA publication-title: J. Drug Target. doi: 10.3109/1061186X.2011.622404 – volume: 41 start-page: 935 year: 2015 ident: 10.1016/j.drudis.2020.06.006_bib0255 article-title: Genetic polymorphisms and paclitaxel-or docetaxel-induced toxicities: a systematic review publication-title: Cancer Treat. Rev. doi: 10.1016/j.ctrv.2015.10.010 – volume: 8 start-page: 165 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0115 article-title: Mesoporous silica nanoparticles for drug and gene delivery publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2018.01.007 – volume: 279 start-page: 107 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0295 article-title: Formulation and development of smart pH responsive mesoporous silica nanoparticles for breast cancer targeted delivery of anastrozole: In vitro and in vivo characterizations publication-title: Microporous Mesoporous Mater. doi: 10.1016/j.micromeso.2018.12.026 – volume: 8 start-page: 6811 year: 2016 ident: 10.1016/j.drudis.2020.06.006_bib0350 article-title: Tailoring particle size of mesoporous silica nanosystem to antagonize glioblastoma and overcome blood–brain barrier publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.5b11730 – volume: 65 start-page: 1731 year: 2013 ident: 10.1016/j.drudis.2020.06.006_bib0270 article-title: Exploiting nanotechnology to overcome tumor drug resistance: challenges and opportunities publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2013.09.001 – volume: 278 start-page: 142 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0275 article-title: Electrosprayed mesoporous particles for improved aqueous solubility of a poorly water soluble anticancer agent: In vitro and ex vivo evaluation publication-title: J. Control. Release doi: 10.1016/j.jconrel.2018.03.031 – volume: 12 start-page: 317 year: 2016 ident: 10.1016/j.drudis.2020.06.006_bib0125 article-title: Advances in silica based nanoparticles for targeted cancer therapy publication-title: Nanomedicine doi: 10.1016/j.nano.2015.10.018 – volume: 5 start-page: 4131 year: 2011 ident: 10.1016/j.drudis.2020.06.006_bib0140 article-title: Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model publication-title: ACS Nano doi: 10.1021/nn200809t – volume: 122 start-page: 1090 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0060 article-title: A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2018.09.058 – volume: 10 start-page: 591 year: 2014 ident: 10.1016/j.drudis.2020.06.006_bib0150 article-title: A dual‐responsive mesoporous silica nanoparticle for tumor-triggered targeting drug delivery publication-title: Small doi: 10.1002/smll.201301926 – volume: 57 start-page: 10 year: 2014 ident: 10.1016/j.drudis.2020.06.006_bib0165 article-title: pH-controllable drug carrier with SERS activity for targeting cancer cells publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2014.01.042 – volume: 470 start-page: 1 year: 2014 ident: 10.1016/j.drudis.2020.06.006_bib0145 article-title: Mesoporous silica coated gold nanorods loaded doxorubicin for combined chemo-photothermal therapy publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2014.04.067 – volume: 14 start-page: 2010 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0365 article-title: Facile preparation of drug-loaded tristearin encapsulated superparamagnetic iron oxide nanoparticles using coaxial electrospray processing publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.7b00109 – volume: 107 start-page: 2643 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0190 article-title: Targeted and stimuli-responsive mesoporous silica nanoparticles for drug delivery and theranostic use publication-title: J Biomed Mat Res A doi: 10.1002/jbm.a.36770 – volume: 11 start-page: 77 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0340 article-title: Mesoporous silica nanomaterials: versatile nanocarriers for cancer theranostics and drug and gene delivery publication-title: Pharmaceutics doi: 10.3390/pharmaceutics11020077 – volume: 7 start-page: 13104 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0020 article-title: Comparison of different silica microporous structures as drug delivery systems for in vitro models of solid tumors publication-title: RSC Adv. doi: 10.1039/C7RA01028A – volume: 14 start-page: 229 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0005 article-title: Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer publication-title: Expert Opin. Drug Deliv. doi: 10.1080/17425247.2016.1211637 – volume: 5 start-page: 77 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0325 article-title: Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment publication-title: Biomater. Sci. doi: 10.1039/C6BM00449K – volume: 570 start-page: 386 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0245 article-title: Hollow mesoporous carbon modified with cRGD peptide nanoplatform for targeted drug delivery and chemo-photothermal therapy of prostatic carcinoma publication-title: Colloids Surf. A Physicochem. Eng. Asp. doi: 10.1016/j.colsurfa.2019.03.030 – volume: 100 start-page: 855 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0085 article-title: Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2019.03.028 – volume: 7 start-page: 189 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0135 article-title: Mesoporous silica nanoparticles as drug delivery vehicles in cancer publication-title: Nanomaterials doi: 10.3390/nano7070189 – volume: 45 start-page: 1487 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0290 article-title: Combined chemo/photothermal therapy based on mesoporous silica-au core-shell nanoparticles for hepatocellular carcinoma treatment publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639045.2019.1629688 – volume: 11 start-page: 4890 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0160 article-title: General synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting publication-title: Nano Res. doi: 10.1007/s12274-018-2078-9 – volume: 77 start-page: 403 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0300 publication-title: Eur. Urol. doi: 10.1016/j.eururo.2019.01.049 – volume: 14 start-page: 5785 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0080 article-title: Hyaluronic acid-modified mesoporous silica–coated superparamagnetic Fe3O4 nanoparticles for targeted drug delivery publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S213974 – volume: 11 start-page: 265 year: 2000 ident: 10.1016/j.drudis.2020.06.006_bib0265 article-title: Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(00)00114-7 – volume: 14 start-page: 1443 year: 2019 ident: 10.1016/j.drudis.2020.06.006_bib0090 article-title: Mesoporous gold nanoparticles for photothermal controlled anticancer drug delivery publication-title: Nanomedicine doi: 10.2217/nnm-2018-0242 – volume: 26 start-page: 5745 year: 2018 ident: 10.1016/j.drudis.2020.06.006_bib0110 article-title: Multifunctional mesoporous silica nanoparticles for cancer therapy and imaging publication-title: Curr. Med. Chem. doi: 10.2174/0929867325666180501101044 – volume: 121 start-page: 109614 year: 2020 ident: 10.1016/j.drudis.2020.06.006_bib0305 article-title: PSA targeted dual-modality manganese oxide-mesoporous silica nanoparticles for prostate cancer imaging publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2019.109614 – volume: 18 start-page: 1507 year: 2017 ident: 10.1016/j.drudis.2020.06.006_bib0010 article-title: Porous inorganic drug delivery systems—a review publication-title: AAPS PharmSciTech doi: 10.1208/s12249-017-0740-2 |
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