The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities
•HMTp210 is the major haemagglutinin of Av. paragallinarum.•HMTp210 is a trimeric autotransporter adhesin.•HMTp210 is involved in cell adherence and biofilms formation of Av. paragallinarum.•Targetron gene knockout system can be used in Av. paragallinarum. The haemagglutinin (HA) protein plays a key...
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| Published in | Veterinary microbiology Vol. 174; no. 3-4; pp. 474 - 482 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
05.12.2014
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| Online Access | Get full text |
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| Abstract | •HMTp210 is the major haemagglutinin of Av. paragallinarum.•HMTp210 is a trimeric autotransporter adhesin.•HMTp210 is involved in cell adherence and biofilms formation of Av. paragallinarum.•Targetron gene knockout system can be used in Av. paragallinarum.
The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron® gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. |
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| AbstractList | •HMTp210 is the major haemagglutinin of Av. paragallinarum.•HMTp210 is a trimeric autotransporter adhesin.•HMTp210 is involved in cell adherence and biofilms formation of Av. paragallinarum.•Targetron gene knockout system can be used in Av. paragallinarum.
The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron® gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron(®) gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum.The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron(®) gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron super( registered ) gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron® gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was previously reported to be the HA of Av. paragallinarum, but the biological function of HMTp210 is not well defined. In this study, mutant strains that lacked HMTp210 were constructed using the TargeTron(®) gene knockout system. Haemagglutination and haemagglutination-inhibition (HI) assays showed that the HMTp210-deficient mutants exhibited no HA activity and failed to elicit HI antibodies in immunized chickens. Additionally, HMTp210-deficient mutants exhibited reduced ability to adhere to HeLa cells and to form biofilms on abiotic surfaces. Virulence assays showed that HMTp210-deficient mutants are less virulent than their isogenic wild-type strains. HMTp210 bears significant similarity to proteins of the trimeric autotransporter adhesin (TAA) family, and recombinant HMTp210 expressed in E. coli formed a trimeric structure. Taken together, these results indicated that HMTp210 is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. These results should prove valuable to further elucidate the biological function of HA and the mechanism of pathogenicity of Av. paragallinarum. |
| Author | Wang, Yi-Ping Chen, Chih-Feng Hsieh, Ming-Kun Tan, Duen-Huey Chang, Poa-Chun Shien, Jui-Hung Ou, Shan-Chia |
| Author_xml | – sequence: 1 givenname: Yi-Ping surname: Wang fullname: Wang, Yi-Ping organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan – sequence: 2 givenname: Ming-Kun surname: Hsieh fullname: Hsieh, Ming-Kun organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan – sequence: 3 givenname: Duen-Huey surname: Tan fullname: Tan, Duen-Huey organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan – sequence: 4 givenname: Jui-Hung surname: Shien fullname: Shien, Jui-Hung organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan – sequence: 5 givenname: Shan-Chia surname: Ou fullname: Ou, Shan-Chia organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan – sequence: 6 givenname: Chih-Feng surname: Chen fullname: Chen, Chih-Feng organization: Department of Animal Science, National Chung Hsing University, Taichung 402, Taiwan – sequence: 7 givenname: Poa-Chun surname: Chang fullname: Chang, Poa-Chun email: pcchang@mail.nchu.edu.tw organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25465664$$D View this record in MEDLINE/PubMed |
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| Copyright | 2014 Elsevier B.V. Copyright © 2014 Elsevier B.V. All rights reserved. |
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| Keywords | Avibacterium paragallinarum HMTp210 Haemagglutinin Trimeric autotransporter |
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| Snippet | •HMTp210 is the major haemagglutinin of Av. paragallinarum.•HMTp210 is a trimeric autotransporter adhesin.•HMTp210 is involved in cell adherence and biofilms... The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum. A 210-kDa protein (HMTp210) was... |
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| SubjectTerms | adhesins Adhesins, Bacterial - genetics Adhesins, Bacterial - immunology Animals antibodies Avibacterium paragallinarum biofilm Biofilms - growth & development Chickens Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism gene targeting Haemagglutinin Haemophilus Infections - microbiology Haemophilus paragallinarum - genetics Haemophilus paragallinarum - immunology Haemophilus paragallinarum - physiology HeLa Cells hemagglutination Hemagglutination - drug effects Hemagglutination Tests - veterinary hemagglutinins Hemagglutinins - genetics Hemagglutinins - immunology HMTp210 Humans mutants Trimeric autotransporter Type V Secretion Systems - genetics Type V Secretion Systems - immunology virulence |
| Title | The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities |
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