A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

• Published in: Cancer letters Vol. 400; pp. 79 - 88
• Main Authors: Wu, Yuan-Hua, Hong, Chi-Wei, Wang, Yi-Ching, Huang, Wei-Jan, Yeh, Ya-Ling, Wang, Bour-Jr, Wang, Ying-Jan, Chiu, Hui-Wen
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2017; Elsevier Limited
• Subjects: Acetylation; Acridines - pharmacology; AKT protein; American Type Culture Collection; Androgens; Angiogenesis inhibitors; Animal models; Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antitumor agents; Apoptosis; Apoptosis - drug effects; Atmosphere; Autophagy; Autophagy - drug effects; Breast cancer; Cancer therapies; Carrier Proteins - metabolism; Cell cycle; Cell death; Cell Line, Tumor; Chemotherapy; Chromatin; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA Damage; DNA End-Joining Repair - drug effects; DNA repair; DNA-Activated Protein Kinase - metabolism; DNA-Binding Proteins - metabolism; Dose-Response Relationship, Drug; Drug Synergism; Drugs; Enzymes; Etoposide - pharmacology; Female; Gene expression; Hematology, Oncology and Palliative Medicine; Histone Deacetylase Inhibitors - pharmacology; Humans; Hydroxamic Acids - pharmacology; Inflammation; Kinases; Lymphoma; Medical prognosis; Membrane vesicles; Metastases; Mice; Mice, Inbred BALB C; Mice, Nude; Nuclear Proteins - metabolism; Organelles; Proteasome Endopeptidase Complex - metabolism; Proteasomes; Proteins; Proteolysis; Time Factors; Topoisomerase II Inhibitors - pharmacology; Transmissible spongiform encephalopathy; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - enzymology; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - pathology; Triple-negative breast cancer; Tumor cells; Tumors; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitin–proteasome system; DNA repair; DNA damage; Ubiquitin–proteasome system; Triple-negative breast cancer; ubiquitin-proteasome system; triple-negative breast cancer

Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylas...