Differential expression of prognostic biomarkers between interval and screen-detected breast cancers: does age or family history matter?

• Published in: Breast cancer research and treatment Vol. 129; no. 1; pp. 211 - 219
• Main Authors: Lowery, Jan T., Byers, Tim, Kittelson, John, Hokanson, John E., Mouchawar, Judy, Lewin, John, Merrick, Dan, Hines, Lisa, Singh, Meenakshi
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.08.2011; Springer; Springer Nature B.V
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Biomarkers; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer research; Cancer therapies; Diagnostic tests; Epidemiology; Family medical history; Female; Gynecology. Andrology. Obstetrics; Host-tumor relations. Immunology. Biological markers; Humans; Mammary gland diseases; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Pharmacology. Drug treatments; Prognosis; Risk factors; Tumors; Biomarkers; Interval breast cancer; Tissue micro-arrays; Breast disease; Prognosis; Etiopathogenesis; Biological marker; Breast cancer; Malignant tumor; Medical screening; Gene expression; Mammary gland diseases; Family story; Treatment; Tissue microarrays; Age; Antecedent; Cancer; Interval

The aim of this study was to compare tumor expression of prognostic biomarkers between interval breast cancers and screen-detected breast cancers overall, and according to age at diagnosis and familial risk. Tissue micro-arrays were constructed from 98 breast cancers (47 interval and 51 screen-detec...