Blood alcohol concentration and psychomotor effects

This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml−1) and an oral dose of a...

Full description

Saved in:

Bibliographic Details
Published in	British journal of anaesthesia : BJA Vol. 85; no. 3; pp. 401 - 406
Main Authors	Grant, S.A., Millar, K., Kenny, G.N.C.
Format	Journal Article
Language	English
Published	Oxford Elsevier Ltd 01.09.2000 Oxford University Press Oxford Publishing Limited (England)
Subjects	Administration, Oral Adult alcohol Alcohol Drinking - adverse effects Alcoholism and acute alcohol poisoning Biological and medical sciences Breath Tests Central Nervous System Depressants - blood Central Nervous System Depressants - pharmacology Ethanol - blood Ethanol - pharmacology Female Humans Infusions, Intravenous Male Medical sciences psychomotor Psychomotor Performance - drug effects Reaction Time - drug effects Reflex - drug effects reflexes reflexes, psychomotor Toxicology alcohol reflexes, psychomotor reflexes, psychomotor; alcohol Human Intravenous administration Healthy subject Activity concentration relation Oral administration Alcohol Psychomotricity
Online Access	Get full text
ISSN	0007-0912 1471-6771
DOI	10.1093/bja/85.3.401

Cover

Loading…

Abstract	This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml−1) and an oral dose of alcohol 0.75 mg kg−1. Twelve volunteers, aged 22–34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml−1, the mean (sd) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml−1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg−1 ranged from 19 to 68 mg 100 ml−1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P<0.05) and 80 mg 100 ml−1 (P<0.01) conditions. Dual-task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P<0.05; 50 and 80 mg groups, P<0.01). Dual-task tracking in the 50 and 80 mg groups was significantly different from baseline (P<0.05 and P<0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance.
AbstractList	This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml-1) and an oral dose of alcohol 0.75 mg kg-1. Twelve volunteers, aged 22-34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml-1, the mean (SD) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml-1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg-1 ranged from 19 to 68 mg 100 ml-1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P < 0.05) and 80 mg 100 ml-1 (P < 0.01) conditions. Dual-task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P < 0.05; 50 and 80 mg groups, P < 0.01). Dual-task tracking in the 50 and 80 mg groups was significantly different from baseline (P < 0.05 and P < 0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance. This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink‐driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml–1) and an oral dose of alcohol 0.75 mg kg–1. Twelve volunteers, aged 22–34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml–1, the mean (sd) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml–1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg–1 ranged from 19 to 68 mg 100 ml–1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P<0.05) and 80 mg 100 ml–1 (P<0.01) conditions. Dual‐task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P<0.05; 50 and 80 mg groups, P<0.01). Dual‐task tracking in the 50 and 80 mg groups was significantly different from baseline (P<0.05 and P<0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance. Br J Anaesth 2000; 85: 401–6 This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml-1) and an oral dose of alcohol 0.75 mg kg-1. Twelve volunteers, aged 22-34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml-1, the mean (SD) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml-1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg-1 ranged from 19 to 68 mg 100 ml-1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P < 0.05) and 80 mg 100 ml-1 (P < 0.01) conditions. Dual-task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P < 0.05; 50 and 80 mg groups, P < 0.01). Dual-task tracking in the 50 and 80 mg groups was significantly different from baseline (P < 0.05 and P < 0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance.This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml-1) and an oral dose of alcohol 0.75 mg kg-1. Twelve volunteers, aged 22-34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml-1, the mean (SD) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml-1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg-1 ranged from 19 to 68 mg 100 ml-1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P < 0.05) and 80 mg 100 ml-1 (P < 0.01) conditions. Dual-task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P < 0.05; 50 and 80 mg groups, P < 0.01). Dual-task tracking in the 50 and 80 mg groups was significantly different from baseline (P < 0.05 and P < 0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance. This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink-driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml−1) and an oral dose of alcohol 0.75 mg kg−1. Twelve volunteers, aged 22–34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml−1, the mean (sd) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml−1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg−1 ranged from 19 to 68 mg 100 ml−1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P<0.05) and 80 mg 100 ml−1 (P<0.01) conditions. Dual-task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P<0.05; 50 and 80 mg groups, P<0.01). Dual-task tracking in the 50 and 80 mg groups was significantly different from baseline (P<0.05 and P<0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance. This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons were made between three European drink‐driving limits of blood alcohol concentration (BAC) (20, 50 and 80 mg 100 ml–1) and an oral dose of alcohol 0.75 mg kg–1. Twelve volunteers, aged 22–34 yr, were recruited. At targets of 20, 50 and and 80 mg 100 ml–1, the mean (sd) BAC was 22.1 (3.7), 51.5 (3.3) and 80.5 (4.2) mg 100 ml–1, respectively. The peak BAC following an oral dose of alcohol 0.75 mg kg–1 ranged from 19 to 68 mg 100 ml–1. In psychomotor testing, choice reaction time deteriorated with increasing BAC and showed significant differences between baseline and the 50 (P<0.05) and 80 mg 100 ml–1 (P<0.01) conditions. Dual‐task secondary reaction time deteriorated with increasing BAC and showed a statistically significant difference between all groups and baseline (oral and 20 mg groups, P<0.05; 50 and 80 mg groups, P<0.01). Dual‐task tracking in the 50 and 80 mg groups was significantly different from baseline (P<0.05 and P<0.01, respectively). Oral dosing resulted in widely variable BACs, making it difficult to assess psychomotor impairment reliably. An intravenous infusion enables the BAC to be maintained within a narrow range. This allows precision when investigating the effects of alcohol on psychomotor performance. Br J Anaesth 2000; 85: 401–6
Author	Millar, K. Grant, S. A. Kenny, G. N. C.
Author_xml	– sequence: 1 givenname: S.A. surname: Grant fullname: Grant, S.A. organization: Glasgow University Department of Anaesthesia, Royal Infirmary, 8–16 Alexandra Parade, Glasgow G31 2ER, UK – sequence: 2 givenname: K. surname: Millar fullname: Millar, K. organization: University Department of Psychological Medicine, Division of Behavioural Sciences, Academic Centre, Gartnaval Royal Hospital, 1055 Great Western Road, Glasgow G12 0XH, UK – sequence: 3 givenname: G.N.C. surname: Kenny fullname: Kenny, G.N.C. organization: Glasgow University Department of Anaesthesia, Royal Infirmary, 8–16 Alexandra Parade, Glasgow G31 2ER, UK
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1482804$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11103181$$D View this record in MEDLINE/PubMed
BookMark	eNqF0cFrFDEUBvAgFbut3jzLIKKXzjaZZCbJURfbFQpeFKWXkEleaNbZZJvMiP3vTZ1tC0XxlMvvvTy-7wgdhBgAoZcELwmW9LTf6FPRLumSYfIELQjjpO44JwdogTHmNZakOURHOW8wJryR7TN0SAjBlAiyQPTDEKOt9GDiVRwqE4OBMCY9-hgqHWy1yzfmKm7jGFMFzoEZ83P01Okhw4v9e4y-nn38slrXF5_PP63eX9SGSTHWHRHU9H1DOUgrmWxbwphrsNUgALvGApi2Z85RCm1vjQApjeNC4L6XzjB6jN7Oe3cpXk-QR7X12cAw6ABxyoo3jErGRIGvH8FNnFIotykiOW8F5V1Br_Zo6rdg1S75rU436i6LAt7sgc5GDy7pYHx-cEw0At9edTIzk2LOCdyDwOq2EVUaUaJVVJVGCm8ecePHP_GWlP3wr6F381Ccdv9bX8_S5xF-3VudfqiOU96q9fdLRc8uV2v2baVw8d3soRT300NS2XgopVufSrfKRv_3j34DzQC79Q
CODEN	BJANAD
CitedBy_id	crossref_primary_10_1016_j_beproc_2010_02_006 crossref_primary_10_1097_00003643_200100001_00059 crossref_primary_10_1097_MCG_0000000000000492 crossref_primary_10_1038_sj_npp_1301023 crossref_primary_10_1016_S0925_4927_03_00063_5 crossref_primary_10_1097_01_ALC_0000153546_39946_EC crossref_primary_10_1111_j_1530_0277_2002_tb02446_x crossref_primary_10_1007_s00414_015_1182_6 crossref_primary_10_1046_j_1365_2044_2001_02086_x crossref_primary_10_1177_0269881111398685 crossref_primary_10_17986_blm_1364 crossref_primary_10_1002_hup_2725 crossref_primary_10_1111_j_1365_2044_2004_03580_x crossref_primary_10_1111_j_1365_2125_2010_03846_x crossref_primary_10_1111_1556_4029_12227 crossref_primary_10_1016_j_ajem_2007_10_033 crossref_primary_10_1002_wfs2_1326 crossref_primary_10_1007_s00414_014_1104_z crossref_primary_10_1016_j_pscychresns_2005_04_001 crossref_primary_10_1177_0310057X1604400602 crossref_primary_10_1007_BF03018752 crossref_primary_10_1016_j_alcohol_2007_04_003 crossref_primary_10_1007_s11065_007_9038_6 crossref_primary_10_1016_j_aap_2016_01_001 crossref_primary_10_3389_fphys_2019_00097 crossref_primary_10_3109_00952990_2013_846349 crossref_primary_10_2466_pms_2003_96_3c_1197 crossref_primary_10_1177_0269881115570080 crossref_primary_10_7861_clinmed_22_4_s44 crossref_primary_10_1080_01616412_2019_1602322 crossref_primary_10_1016_j_trf_2019_02_001 crossref_primary_10_1177_1460408620905398 crossref_primary_10_36303_SAJAA_2020_26_6_2361 crossref_primary_10_4062_biomolther_2020_108 crossref_primary_10_1093_bja_85_3_396
Cites_doi	10.1007/BF00625799 10.1111/j.1399-6576.1993.tb03746.x 10.1046/j.1365-2044.1998.00434.x 10.1093/bja/59.8.970 10.1007/s002280050369 10.1111/j.1360-0443.1993.tb02059.x 10.1520/JFS14025J 10.1016/S0091-6749(98)70240-4 10.1111/j.1530-0277.1999.tb04188.x 10.1093/oxfordjournals.alcalc.a008294 10.1111/j.2044-8295.1992.tb02440.x 10.1097/00000542-199501000-00008 10.1111/j.1365-2044.1988.tb06685.x 10.1093/bja/67.1.41 10.1093/ageing/28.1.59 10.1007/BF01371332 10.1111/j.1365-2125.1979.tb05903.x 10.1016/S0016-5085(96)70054-9
ContentType	Journal Article
Copyright	2000 British Journal of Anaesthesia 2000 2000 INIST-CNRS Copyright British Medical Association Sep 2000
Copyright_xml	– notice: 2000 British Journal of Anaesthesia – notice: 2000 – notice: 2000 INIST-CNRS – notice: Copyright British Medical Association Sep 2000
DBID	6I. AAFTH BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM K9. 7X8
DOI	10.1093/bja/85.3.401
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest Health & Medical Complete (Alumni) MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
EISSN	1471-6771
EndPage	406
ExternalDocumentID	60010679 11103181 1482804 10_1093_bja_85_3_401 10.1093/bja/85.3.401 ark_67375_HXZ_3FZCH4WC_0 S0007091217376626
Genre	Clinical Trial Journal Article Comparative Study
GroupedDBID	--- -E4 .2P .55 .GJ .I3 .XZ .ZR 18M 1TH 23N 2WC 354 3O- 4.4 482 48X 53G 5GY 5RE 5VS 5WA 6.Y 6I. 6PF 70D AACTN AAEDW AAESY AAFTH AAIAV AAIYJ AAJKP AALRI AAMVS AAOGV AAPNW AAPXW AAQQT AAUQX AAVAP AAWTL AAXUO ABEUO ABIXL ABJNI ABKDP ABLJU ABMAC ABNKS ABPTD ABQLI ABQTQ ABSMQ ABVKL ABXVV ABZBJ ACCJX ACFRR ACGFO ACGFS ACMRT ACPQN ACUFI ACUTJ ACUTO ADBBV ADEYI ADHKW ADHZD ADJQC ADOCK ADORX ADQLU ADRIX ADZXQ AEGPL AEJOX AEKPW AEMDU AENEX AENZO AEPUE AEWNT AFFNX AFIYH AFOSN AFTJW AFXEN AGKEF AGKRT AGSYK AHMBA AHPSJ AHXPO AI. AIAGR AIJHB AITUG ALMA_UNASSIGNED_HOLDINGS ALUQC AMRAJ APIBT APWMN ASPBG AVWKF AWCFO AXUDD AZFZN BAWUL BEYMZ BGYMP BHONS BVRKM BZKNY C1A C45 CAG COF CS3 CZ4 DIK DILTD DU5 D~K E3Z EBS EE~ EJD F5P F9B FDB FEDTE GX1 H5~ HAR HVGLF HW0 HZ~ IH2 IOX J21 J5H KAQDR KC5 KOP KQ8 KSI KSN L7B M-Z M41 M49 N9A NCXOZ NGC NTWIH NU- O0~ OAWHX OHH OJQWA OJZSN OK1 OVD O~Y P2P PB- PEELM PQQKQ Q1. Q5Y R44 RD5 RHF RNI ROL ROX ROZ RW1 RXO RZF RZO SSZ TEORI TJX TMA TR2 VH1 W2D W8F WH7 WOQ WOW X7H X7M YHG ZA5 ZGI ZKX ZXP ~91 AAFWJ AAYWO ABEJV ABGNP ABNGD ACUKT ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AGCQF AGQPQ AIGII AKBMS AKRWK AKYEP BSCLL EFKBS 0SF 0R~ AAYXX ACVCV AEHUL AFETI AFSHK AGMDO APJGH APXCP CITATION H13 P0W IQODW CGR CUY CVF ECM EIF NPM K9. 7X8
ID	FETCH-LOGICAL-c498t-6183cbb237e9d94955144f20dae8e0f2deec5b4ff33e5bdc8e99cf7880bb9fc43
ISSN	0007-0912
IngestDate	Fri Jul 11 15:48:32 EDT 2025 Fri Jul 25 08:14:38 EDT 2025 Wed Feb 19 02:35:10 EST 2025 Mon Jul 21 09:12:45 EDT 2025 Thu Apr 24 22:56:57 EDT 2025 Tue Jul 01 02:00:47 EDT 2025 Wed Aug 28 03:19:57 EDT 2024 Tue Aug 05 16:51:05 EDT 2025 Fri Feb 23 02:34:56 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	alcohol reflexes, psychomotor reflexes, psychomotor; alcohol Human Intravenous administration Healthy subject Activity concentration relation Oral administration Alcohol Psychomotricity
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 https://www.elsevier.com/open-access/userlicense/1.0 CC BY 4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c498t-6183cbb237e9d94955144f20dae8e0f2deec5b4ff33e5bdc8e99cf7880bb9fc43
Notes	istex:C06A8095BEEBCB37481D224BABDE29CB9E0FC230 ark:/67375/HXZ-3FZCH4WC-0 local:aed070 Accepted for publication: April 26, 2000 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 content type line 23
OpenAccessLink	https://dx.doi.org/10.1093/bja/85.3.401
PMID	11103181
PQID	197758376
PQPubID	41750
PageCount	6
ParticipantIDs	proquest_miscellaneous_72439448 proquest_journals_197758376 pubmed_primary_11103181 pascalfrancis_primary_1482804 crossref_primary_10_1093_bja_85_3_401 crossref_citationtrail_10_1093_bja_85_3_401 oup_primary_10_1093_bja_85_3_401 istex_primary_ark_67375_HXZ_3FZCH4WC_0 elsevier_sciencedirect_doi_10_1093_bja_85_3_401
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2000-09-01
PublicationDateYYYYMMDD	2000-09-01
PublicationDate_xml	– month: 09 year: 2000 text: 2000-09-01 day: 01
PublicationDecade	2000
PublicationPlace	Oxford
PublicationPlace_xml	– name: Oxford – name: England – name: London
PublicationTitle	British journal of anaesthesia : BJA
PublicationTitleAbbrev	Br. J. Anaesth
PublicationTitleAlternate	Br. J. Anaesth
PublicationYear	2000
Publisher	Elsevier Ltd Oxford University Press Oxford Publishing Limited (England)
Publisher_xml	– name: Elsevier Ltd – name: Oxford University Press – name: Oxford Publishing Limited (England)
References	Thapar, Zacny, Thompson, Apfelbaum (bib17) 1995; 82 Burns, Moskowitz (bib22) 1980; 17 Kechagias, Jonsson, Norlander, Carlsson, Jones (bib6) 1997; 53 Seitz, Poschl (bib5) 1997; 32 Klein (bib16) 1972; 43 Ferrara, Zancaner, Giorgetti (bib2) 1994; 106 Nightingale, Stock, McKiernon, Wilton (bib12) 1988; 43 Millar, Finnigan, Hammersley (bib25) 1999; 70 Burns, Moskowitz (bib18) 1980; 17 Jones, Andersson (bib20) 1996; 41 Thapar, Zacny, Choi, Apfelbaum (bib15) 1995; 80 Willette, Walsh (bib1) 1983 Millar (bib9) 1992 Moss, Hindmarch, Pain, Edmondson (bib23) 1987; 59 Marsh, White, Morton, Kenny (bib13) 1991; 67 Millar, Hammersley, Finnigan (bib10) 1992; 83 West, Wilding, French, Kemp, Irving (bib24) 1993; 88 Haber, Gentry, Mak, Mirmiran-Yadzy, Greenstein, Lieber (bib7) 1996; 111 Vermeeren, O’Hanlon (bib26) 1998; 101 Davidson, MacLeod, Howie, White, Kenny (bib21) 1993; 37 Quillian, Cox, Kovatchev, Phillips (bib4) 1999; 28 Hills, Armitage (bib14) 1979; 8 Moss, Hindmarch, Pan, Edmondson (bib11) 1987; 59 Tiplady (bib19) 1991 Liguori, D’Agostino, Dworkin, Edwards, Robinson (bib3) 1999; 23 Hope, Woolman, Gray, Asbury, Millar (bib8) 1998; 53 Burns (10.1093/bja/85.3.401_bib18) 1980; 17 Hope (10.1093/bja/85.3.401_bib8) 1998; 53 Kechagias (10.1093/bja/85.3.401_bib6) 1997; 53 Millar (10.1093/bja/85.3.401_bib10) 1992; 83 Moss (10.1093/bja/85.3.401_bib23) 1987; 59 Quillian (10.1093/bja/85.3.401_bib4) 1999; 28 Liguori (10.1093/bja/85.3.401_bib3) 1999; 23 Millar (10.1093/bja/85.3.401_bib9) 1992 Thapar (10.1093/bja/85.3.401_bib17) 1995; 82 Jones (10.1093/bja/85.3.401_bib20) 1996; 41 West (10.1093/bja/85.3.401_bib24) 1993; 88 Millar (10.1093/bja/85.3.401_bib25) 1999; 70 Burns (10.1093/bja/85.3.401_bib22) 1980; 17 Klein (10.1093/bja/85.3.401_bib16) 1972; 43 Hills (10.1093/bja/85.3.401_bib14) 1979; 8 Thapar (10.1093/bja/85.3.401_bib15) 1995; 80 Seitz (10.1093/bja/85.3.401_bib5) 1997; 32 Tiplady (10.1093/bja/85.3.401_bib19) 1991 Marsh (10.1093/bja/85.3.401_bib13) 1991; 67 Willette (10.1093/bja/85.3.401_bib1) 1983 Moss (10.1093/bja/85.3.401_bib11) 1987; 59 Davidson (10.1093/bja/85.3.401_bib21) 1993; 37 Ferrara (10.1093/bja/85.3.401_bib2) 1994; 106 Vermeeren (10.1093/bja/85.3.401_bib26) 1998; 101 Haber (10.1093/bja/85.3.401_bib7) 1996; 111 Nightingale (10.1093/bja/85.3.401_bib12) 1988; 43 Br J Anaesth 2001 Feb;86(2):302
References_xml	– volume: 101 start-page: 306 year: 1998 end-page: 311 ident: bib26 article-title: Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance publication-title: J Allergy Clin Immun – volume: 106 start-page: 169 year: 1994 end-page: 177 ident: bib2 article-title: Low blood alcohol concentrations and driving impairment: a review of experimental studies and international legislation publication-title: Int J Legal Med – start-page: 26 year: 1991 end-page: 37 ident: bib19 article-title: Alcohol as a comparator publication-title: Ambulatory Anesthesia and Sedation – volume: 59 start-page: 970 year: 1987 end-page: 977 ident: bib23 article-title: Comparison of recovery after halothane or alfentanil anaesthesia for minor surgery publication-title: Br J Anaesth – volume: 37 start-page: 458 year: 1993 end-page: 464 ident: bib21 article-title: Effective concentration for propofol with and without 67% nitrous oxide publication-title: Acta Anaesthiol Scand – volume: 53 start-page: 545 year: 1998 end-page: 550 ident: bib8 article-title: A system for psychomotor evaluation; design, implementation and practice effects in volunteers publication-title: Anaesthesia – volume: 17 start-page: 259 year: 1980 end-page: 266 ident: bib22 article-title: Effects of diphenhydramine and alcohol on skills performance publication-title: Eur J Clin Pharmacol – volume: 70 start-page: 124 year: 1999 end-page: 130 ident: bib25 article-title: Is residual impairment after alcohol an effect of repeated performance? publication-title: Aviation Space Envir Med – volume: 23 start-page: 812 year: 1999 end-page: 815 ident: bib3 article-title: Alcohol effects on mood, equilibrium, and simulated driving publication-title: Alcohol Clin Exp Res – volume: 111 start-page: 863 year: 1996 end-page: 870 ident: bib7 article-title: Metabolism of alcohol by human gastric cells: relation to first pass metabolism publication-title: Gastroenterology – volume: 43 start-page: 554 year: 1988 end-page: 556 ident: bib12 article-title: Recovery after single breath halothane induction anaesthesia in day case patients publication-title: Anaesthesia – volume: 53 start-page: 241 year: 1997 end-page: 246 ident: bib6 article-title: Low-dose aspirin decreases blood alcohol concentrations by delaying gastric emptying publication-title: Eur J Clin Pharm – volume: 8 start-page: 7 year: 1979 end-page: 20 ident: bib14 article-title: The two-period cross over clinical trial publication-title: Br J Clin Pharmacol – volume: 80 start-page: 1092 year: 1995 end-page: 1098 ident: bib15 article-title: Objective and subjective impairment from often used sedative/analgesic combinations in ambulatory surgery, using alcohol as a benchmark publication-title: Anesth Analg – volume: 67 start-page: 41 year: 1991 end-page: 48 ident: bib13 article-title: Pharmacokinetic model driven infusion model of propofol in children publication-title: Br J Anaesth – volume: 17 start-page: 259 year: 1980 end-page: 266 ident: bib18 article-title: Effects of diphenhydramine and alcohol on skills performance publication-title: Eur J Clin Pharmacol – volume: 43 start-page: 1207 year: 1972 end-page: 1214 ident: bib16 article-title: Prediction of flight safety hazards from drug induced performance decrements with alcohol as a reference substance publication-title: Aero Med – start-page: 337 year: 1992 end-page: 385 ident: bib9 article-title: Effects of anaesthetic and analgesic drugs publication-title: Handbook of Human Performance – volume: 59 start-page: 970 year: 1987 end-page: 977 ident: bib11 article-title: A comparison of recovery after halothane and alfentanil after minor surgery publication-title: Br J Anaesth – year: 1983 ident: bib1 publication-title: Drugs, Driving, and Traffic Safety – volume: 83 start-page: 261 year: 1992 end-page: 278 ident: bib10 article-title: Reduction of alcohol induced performance impairment by prior ingestion of food publication-title: Br J Psychol – volume: 88 start-page: 527 year: 1993 end-page: 532 ident: bib24 article-title: Effects of low and moderate doses of alcohol on driving hazard perception latency and driving speed publication-title: Addiction – volume: 82 start-page: 53 year: 1995 end-page: 59 ident: bib17 article-title: Using alcohol as a standard to assess the degree of impairment induced by sedative and analgesic drugs used in ambulatory surgery publication-title: Anesthesiology – volume: 28 start-page: 59 year: 1999 end-page: 66 ident: bib4 article-title: The effects of age and alcohol intoxication on simulated driving performance, awareness and self restraint publication-title: Age Ageing – volume: 41 start-page: 916 year: 1996 end-page: 921 ident: bib20 article-title: Variability of blood/breath alcohol ratio in drinking drivers publication-title: J Forensic Sci – volume: 32 start-page: 543 year: 1997 end-page: 549 ident: bib5 article-title: The role of gastrointestinal factors in alcohol metabolism publication-title: Alcohol Alcohol – volume: 17 start-page: 259 year: 1980 ident: 10.1093/bja/85.3.401_bib18 article-title: Effects of diphenhydramine and alcohol on skills performance publication-title: Eur J Clin Pharmacol doi: 10.1007/BF00625799 – volume: 37 start-page: 458 year: 1993 ident: 10.1093/bja/85.3.401_bib21 article-title: Effective concentration for propofol with and without 67% nitrous oxide publication-title: Acta Anaesthiol Scand doi: 10.1111/j.1399-6576.1993.tb03746.x – volume: 53 start-page: 545 year: 1998 ident: 10.1093/bja/85.3.401_bib8 article-title: A system for psychomotor evaluation; design, implementation and practice effects in volunteers publication-title: Anaesthesia doi: 10.1046/j.1365-2044.1998.00434.x – volume: 59 start-page: 970 year: 1987 ident: 10.1093/bja/85.3.401_bib11 article-title: A comparison of recovery after halothane and alfentanil after minor surgery publication-title: Br J Anaesth doi: 10.1093/bja/59.8.970 – volume: 53 start-page: 241 year: 1997 ident: 10.1093/bja/85.3.401_bib6 article-title: Low-dose aspirin decreases blood alcohol concentrations by delaying gastric emptying publication-title: Eur J Clin Pharm doi: 10.1007/s002280050369 – volume: 88 start-page: 527 year: 1993 ident: 10.1093/bja/85.3.401_bib24 article-title: Effects of low and moderate doses of alcohol on driving hazard perception latency and driving speed publication-title: Addiction doi: 10.1111/j.1360-0443.1993.tb02059.x – start-page: 337 year: 1992 ident: 10.1093/bja/85.3.401_bib9 article-title: Effects of anaesthetic and analgesic drugs – volume: 17 start-page: 259 year: 1980 ident: 10.1093/bja/85.3.401_bib22 article-title: Effects of diphenhydramine and alcohol on skills performance publication-title: Eur J Clin Pharmacol doi: 10.1007/BF00625799 – volume: 41 start-page: 916 year: 1996 ident: 10.1093/bja/85.3.401_bib20 article-title: Variability of blood/breath alcohol ratio in drinking drivers publication-title: J Forensic Sci doi: 10.1520/JFS14025J – volume: 101 start-page: 306 year: 1998 ident: 10.1093/bja/85.3.401_bib26 article-title: Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance publication-title: J Allergy Clin Immun doi: 10.1016/S0091-6749(98)70240-4 – volume: 23 start-page: 812 year: 1999 ident: 10.1093/bja/85.3.401_bib3 article-title: Alcohol effects on mood, equilibrium, and simulated driving publication-title: Alcohol Clin Exp Res doi: 10.1111/j.1530-0277.1999.tb04188.x – year: 1983 ident: 10.1093/bja/85.3.401_bib1 – volume: 32 start-page: 543 year: 1997 ident: 10.1093/bja/85.3.401_bib5 article-title: The role of gastrointestinal factors in alcohol metabolism publication-title: Alcohol Alcohol doi: 10.1093/oxfordjournals.alcalc.a008294 – volume: 43 start-page: 1207 year: 1972 ident: 10.1093/bja/85.3.401_bib16 article-title: Prediction of flight safety hazards from drug induced performance decrements with alcohol as a reference substance publication-title: Aero Med – volume: 83 start-page: 261 year: 1992 ident: 10.1093/bja/85.3.401_bib10 article-title: Reduction of alcohol induced performance impairment by prior ingestion of food publication-title: Br J Psychol doi: 10.1111/j.2044-8295.1992.tb02440.x – volume: 70 start-page: 124 year: 1999 ident: 10.1093/bja/85.3.401_bib25 article-title: Is residual impairment after alcohol an effect of repeated performance? publication-title: Aviation Space Envir Med – start-page: 26 year: 1991 ident: 10.1093/bja/85.3.401_bib19 article-title: Alcohol as a comparator – volume: 82 start-page: 53 year: 1995 ident: 10.1093/bja/85.3.401_bib17 article-title: Using alcohol as a standard to assess the degree of impairment induced by sedative and analgesic drugs used in ambulatory surgery publication-title: Anesthesiology doi: 10.1097/00000542-199501000-00008 – volume: 43 start-page: 554 year: 1988 ident: 10.1093/bja/85.3.401_bib12 article-title: Recovery after single breath halothane induction anaesthesia in day case patients publication-title: Anaesthesia doi: 10.1111/j.1365-2044.1988.tb06685.x – volume: 67 start-page: 41 year: 1991 ident: 10.1093/bja/85.3.401_bib13 article-title: Pharmacokinetic model driven infusion model of propofol in children publication-title: Br J Anaesth doi: 10.1093/bja/67.1.41 – volume: 28 start-page: 59 year: 1999 ident: 10.1093/bja/85.3.401_bib4 article-title: The effects of age and alcohol intoxication on simulated driving performance, awareness and self restraint publication-title: Age Ageing doi: 10.1093/ageing/28.1.59 – volume: 80 start-page: 1092 year: 1995 ident: 10.1093/bja/85.3.401_bib15 article-title: Objective and subjective impairment from often used sedative/analgesic combinations in ambulatory surgery, using alcohol as a benchmark publication-title: Anesth Analg – volume: 106 start-page: 169 year: 1994 ident: 10.1093/bja/85.3.401_bib2 article-title: Low blood alcohol concentrations and driving impairment: a review of experimental studies and international legislation publication-title: Int J Legal Med doi: 10.1007/BF01371332 – volume: 8 start-page: 7 year: 1979 ident: 10.1093/bja/85.3.401_bib14 article-title: The two-period cross over clinical trial publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1979.tb05903.x – volume: 111 start-page: 863 year: 1996 ident: 10.1093/bja/85.3.401_bib7 article-title: Metabolism of alcohol by human gastric cells: relation to first pass metabolism publication-title: Gastroenterology doi: 10.1016/S0016-5085(96)70054-9 – volume: 59 start-page: 970 year: 1987 ident: 10.1093/bja/85.3.401_bib23 article-title: Comparison of recovery after halothane or alfentanil anaesthesia for minor surgery publication-title: Br J Anaesth doi: 10.1093/bja/59.8.970 – reference: - Br J Anaesth 2001 Feb;86(2):302
SSID	ssj0017295
Score	1.8163992
Snippet	This study assessed the effect of intravenous alcohol infusions on psychomotor impairment and compared it with that of alcohol administered orally. Comparisons...
SourceID	proquest pubmed pascalfrancis crossref oup istex elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	401
SubjectTerms	Administration, Oral Adult alcohol Alcohol Drinking - adverse effects Alcoholism and acute alcohol poisoning Biological and medical sciences Breath Tests Central Nervous System Depressants - blood Central Nervous System Depressants - pharmacology Ethanol - blood Ethanol - pharmacology Female Humans Infusions, Intravenous Male Medical sciences psychomotor Psychomotor Performance - drug effects Reaction Time - drug effects Reflex - drug effects reflexes reflexes, psychomotor Toxicology
Title	Blood alcohol concentration and psychomotor effects
URI	https://dx.doi.org/10.1093/bja/85.3.401 https://api.istex.fr/ark:/67375/HXZ-3FZCH4WC-0/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/11103181 https://www.proquest.com/docview/197758376 https://www.proquest.com/docview/72439448
Volume	85
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbK7gUJIRCvsCzkAFyqtGnsJM6RrbZbwVIOtCLai2U7tngpu9qmEuLXM46dl6C8LlGVuLbiGY8_T76ZQeg5QKC0UDMZUNi9AkKKJBAixkFCijDTPOZhnUj77SpZbsjrPM5HI91jLe0qMZHffxlX8j9ShXsgVxMl-w-SbTuFG_Ab5AtXkDBc_0rGJ4Z1Pua2yq0hkFuqZdVQjG2IFQjDpPW2xI3BR1yX0KiXPYKXHLaJj2r7idfOgpNOwmewq9UW-33n_zSRhJah_aZvuW30y3jlXLCNUyFsWVNVP1ix5wlz4VYG9rrqIo2nojGsKfThGNHK2lLY94IktRVWGmNr6_M4pcI9y0ns8D9ZdJvtSnwGKL2g8QRPXMNh6uzVO7bYnJ-z9Wm-Hj6tt-rEpsrLbqDDCI4TxoCf5S0VCDBcZitduJdwARIw9BQGnjbD7oMuh2ZBfmsiJG9d8S0sL23rouw_uNQAZn0H3XYnD_-VVaO7aKTKewjXKuQ7FfIHKuTD9Ps9FfKdCt1Hm8Xper4MXB2NQJKMVkECZlsKEeFUZUUGJ2IAyURHYcEVVaGOCqVkLIjWGKtYFJKqLJM6BcsuRKYlwQ_QQXlZqkfIL0QIiJ6HnGhCVESEkAAAuUh0IbUqEg-Nmyli0iWZN7VOvjJLdsAMJpTRmGEGE-qhF23rK5tcZU-7aTPbzAFDC_gYaMmef7yshdJ2y6-_GApjGrNlfsHw4mK-JB_mLPSQD1L7w-jHA5F2jQmNaEg8dNSImLkFu2UzOFfFFHZvDz1rn4LlNp_jeKkud1uWRnVUOvXQQ6sXXcczU3yFzh7_tucjdLNbuk_QQXW9U8eAkCvxtFbvH3MFuTo
linkProvider	Geneva Foundation for Medical Education and Research
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Blood+alcohol+concentration+and+psychomotor+effects&rft.jtitle=British+journal+of+anaesthesia+%3A+BJA&rft.au=Grant%2C+S+A&rft.au=Millar%2C+K&rft.au=Kenny%2C+G+N+C&rft.date=2000-09-01&rft.pub=Oxford+Publishing+Limited+%28England%29&rft.issn=0007-0912&rft.eissn=1471-6771&rft.volume=85&rft.issue=3&rft.spage=401&rft_id=info:doi/10.1093%2Fbja%2F85.3.401&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=60010679
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-0912&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-0912&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-0912&client=summon