Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 10; pp. 4687 - 4692
• Main Authors: Li, Chengjun, Hatta, Masato, Nidom, Chairul A, Muramoto, Yukiko, Watanabe, Shinji, Neumann, Gabriele, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.03.2010; National Acad Sciences
• Subjects: Animals; Biological Sciences; Body Weight; Cell Line; Chick Embryo; chickens; Genetic engineering; Genetics; Humans; hybrids; Influenza; Influenza A virus; Influenza A Virus, H3N2 Subtype - genetics; Influenza A Virus, H3N2 Subtype - pathogenicity; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - pathogenicity; Mice; Mice, Inbred BALB C; Molecular Sequence Data; monitoring; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - physiopathology; Orthomyxoviridae Infections - virology; Pathogenesis; Pathogens; Proteins; Public health; Reassortant Viruses - genetics; Reassortant Viruses - pathogenicity; Ribonucleic acid; ribonucleoproteins; RNA; Species Specificity; Survival Analysis; vertebrate viruses; viability; Viral Proteins - genetics; Virology; virulence; Virulence - genetics; viruses

The spread of avian H5N1 influenza viruses around the globe has become a worldwide public health concern. To evaluate the pathogenic potential of reassortant viruses between currently cocirculating avian H5N1 and human H3N2 influenza viruses, we generated all the 254 combinations of reassortant viru...