Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs

Aims/hypothesis Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. Methods We genotyped 3,089 sib pairs recruited in...

Full description

Saved in:
Bibliographic Details
Published inDiabetologia Vol. 55; no. 2; pp. 349 - 357
Main Authors Gupta, V., Vinay, D. G., Rafiq, S., Kranthikumar, M. V., Janipalli, C. S., Giambartolomei, C., Evans, D. M., Mani, K. R., Sandeep, M. N., Taylor, A. E., Kinra, S., Sullivan, R. M., Bowen, L., Timpson, N. J., Smith, G. D., Dudbridge, F., Prabhakaran, D., Ben-Shlomo, Y., Reddy, K. S., Ebrahim, S., Chandak, G. R.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.02.2012
Springer
Springer Nature B.V
Subjects
Adult
Alleles
Biological and medical sciences
Blood Glucose - metabolism
Chronic illnesses
Diabetes
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Europe
Family Health
Female
Genomes
Genomics
Genotype
Glucose
Human Physiology
Humans
India
Insulin - blood
Insulin - metabolism
Insulin resistance
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Migration
Phenotype
Polymorphism, Genetic
Quantitative Trait Loci
Risk
Siblings
Transients and Migrants
Asia
India
Europe
United Kingdom > UK
Intermediate traits
Type 2 diabetes
Association
Polymorphisms
India
Endocrinopathy
Metabolic diseases
Indian
Polymorphism
Online AccessGet full text

Cover

Abstract Aims/hypothesis Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. Methods We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. Results The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 ( p  = 0.05), 0.01 ( p  = 0.01), 0.007 ( p  = 0.05), 0.01 ( p  = 0.003) and 0.08 ( p  = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B ) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of −0.06 ( p  = 0.04), 0.05 ( p  = 0.05), −0.08 ( p  = 0.01) and −0.08 ( p  = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2 , ADAM30 and CDKN2A/B , with β values of 0.05 ( p  = 0.04), −0.07 ( p  = 0.03) and −0.08 ( p  = 0.02), respectively. We also found significant associations of ADAM30 ( β  = −0.05; p  = 0.01) and CDKN2A/B ( β  = −0.05; p  = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p  = 0.03). Conclusions/interpretation We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.
AbstractList Aims/hypothesis Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. Methods We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. Results The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 ( p  = 0.05), 0.01 ( p  = 0.01), 0.007 ( p  = 0.05), 0.01 ( p  = 0.003) and 0.08 ( p  = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B ) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of −0.06 ( p  = 0.04), 0.05 ( p  = 0.05), −0.08 ( p  = 0.01) and −0.08 ( p  = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2 , ADAM30 and CDKN2A/B , with β values of 0.05 ( p  = 0.04), −0.07 ( p  = 0.03) and −0.08 ( p  = 0.02), respectively. We also found significant associations of ADAM30 ( β  = −0.05; p  = 0.01) and CDKN2A/B ( β  = −0.05; p  = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p  = 0.03). Conclusions/interpretation We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.
Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 (p = 0.05), 0.01 (p = 0.01), 0.007 (p = 0.05), 0.01 (p = 0.003) and 0.08 (p = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of -0.06 (p = 0.04), 0.05 (p = 0.05), -0.08 (p = 0.01) and -0.08 (p = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2, ADAM30 and CDKN2A/B, with β values of 0.05 (p = 0.04), -0.07 (p = 0.03) and -0.08 (p = 0.02), respectively. We also found significant associations of ADAM30 (β = -0.05; p = 0.01) and CDKN2A/B (β = -0.05; p = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p = 0.03). We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.
Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 (p=0.05), 0.01 (p=0.01), 0.007 (p=0.05), 0.01 (p=0.003) and 0.08 (p=0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of -0.06 (p=0.04), 0.05 (p=0.05), -0.08 (p=0.01) and -0.08 (p=0.02), respectively. For HOMA-IR, we detected associations with TCF-2, ADAM30 and CDKN2A/B, with β values of 0.05 (p=0.04), -0.07 (p=0.03) and -0.08 (p=0.02), respectively. We also found significant associations of ADAM30 (β=-0.05; p=0.01) and CDKN2A/B (β=-0.05; p=0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p=0.03). We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.[PUBLICATION ABSTRACT]
AIMS/HYPOTHESISEvaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. METHODSWe genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. RESULTSThe risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 (p = 0.05), 0.01 (p = 0.01), 0.007 (p = 0.05), 0.01 (p = 0.003) and 0.08 (p = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of -0.06 (p = 0.04), 0.05 (p = 0.05), -0.08 (p = 0.01) and -0.08 (p = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2, ADAM30 and CDKN2A/B, with β values of 0.05 (p = 0.04), -0.07 (p = 0.03) and -0.08 (p = 0.02), respectively. We also found significant associations of ADAM30 (β = -0.05; p = 0.01) and CDKN2A/B (β = -0.05; p = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p = 0.03). CONCLUSIONS/INTERPRETATIONWe validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.
Author Gupta, V.
Reddy, K. S.
Evans, D. M.
Bowen, L.
Sullivan, R. M.
Dudbridge, F.
Kinra, S.
Chandak, G. R.
Sandeep, M. N.
Ben-Shlomo, Y.
Taylor, A. E.
Vinay, D. G.
Mani, K. R.
Smith, G. D.
Janipalli, C. S.
Timpson, N. J.
Prabhakaran, D.
Ebrahim, S.
Rafiq, S.
Kranthikumar, M. V.
Giambartolomei, C.
Author_xml – sequence: 1
  givenname: V.
  surname: Gupta
  fullname: Gupta, V.
  email: udaiig@gmail.com
  organization: South Asia Network for Chronic Disease, Public Health Foundation of India, Public Health Foundation of India
– sequence: 2
  givenname: D. G.
  surname: Vinay
  fullname: Vinay, D. G.
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
– sequence: 3
  givenname: S.
  surname: Rafiq
  fullname: Rafiq, S.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
– sequence: 4
  givenname: M. V.
  surname: Kranthikumar
  fullname: Kranthikumar, M. V.
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
– sequence: 5
  givenname: C. S.
  surname: Janipalli
  fullname: Janipalli, C. S.
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
– sequence: 6
  givenname: C.
  surname: Giambartolomei
  fullname: Giambartolomei, C.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
– sequence: 7
  givenname: D. M.
  surname: Evans
  fullname: Evans, D. M.
  organization: School of Social and Community Medicine, University of Bristol, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
– sequence: 8
  givenname: K. R.
  surname: Mani
  fullname: Mani, K. R.
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
– sequence: 9
  givenname: M. N.
  surname: Sandeep
  fullname: Sandeep, M. N.
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
– sequence: 10
  givenname: A. E.
  surname: Taylor
  fullname: Taylor, A. E.
  organization: School of Social and Community Medicine, University of Bristol, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
– sequence: 11
  givenname: S.
  surname: Kinra
  fullname: Kinra, S.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
– sequence: 12
  givenname: R. M.
  surname: Sullivan
  fullname: Sullivan, R. M.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
– sequence: 13
  givenname: L.
  surname: Bowen
  fullname: Bowen, L.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
– sequence: 14
  givenname: N. J.
  surname: Timpson
  fullname: Timpson, N. J.
  organization: School of Social and Community Medicine, University of Bristol, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
– sequence: 15
  givenname: G. D.
  surname: Smith
  fullname: Smith, G. D.
  organization: School of Social and Community Medicine, University of Bristol, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
– sequence: 16
  givenname: F.
  surname: Dudbridge
  fullname: Dudbridge, F.
  organization: Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Bloomsbury Centre for Genetic Epidemiology and Statistics
– sequence: 17
  givenname: D.
  surname: Prabhakaran
  fullname: Prabhakaran, D.
  organization: Centre for Chronic Disease Control
– sequence: 18
  givenname: Y.
  surname: Ben-Shlomo
  fullname: Ben-Shlomo, Y.
  organization: School of Social and Community Medicine, University of Bristol
– sequence: 19
  givenname: K. S.
  surname: Reddy
  fullname: Reddy, K. S.
  organization: South Asia Network for Chronic Disease, Public Health Foundation of India, Public Health Foundation of India
– sequence: 20
  givenname: S.
  surname: Ebrahim
  fullname: Ebrahim, S.
  organization: South Asia Network for Chronic Disease, Public Health Foundation of India, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Bloomsbury Centre for Genetic Epidemiology and Statistics
– sequence: 21
  givenname: G. R.
  surname: Chandak
  fullname: Chandak, G. R.
  email: chandakgrc@ccmb.res.in
  organization: Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR)
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25571502$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22052079$$D View this record in MEDLINE/PubMed
BookMark eNp1kV1rFDEYhYNU7Lb6A7yRIIhXY_M5M7kRSvGjUPCmgnchm2S6KTPJmDdb2X9vxl37IXgVkvO8Jyc5J-gopugRek3JB0pIdwaEUCYbQmnDuJRN-wytqOCsIYL1R2i1yA3t2x_H6ATglhDCpWhfoGPGiGSkUyuUzgGSDaaEFLGJZtxBAJwGzCm2aZrq6ZzG3ZTyvAkwAf4VygaX3ewxwy6YtS8e6qDDoQDOfjTFO1yyWbYh4stYoYghrPFsQoaX6PlgRvCvDusp-v750_XF1-bq25fLi_OrxgrVl0Za6p20nCoxcOIG39uBc9upzirvHBO8U0xaY63rpTCCO694NyhjVMv7lvBT9HHvO2_Xk3fWx5pp1HMOk8k7nUzQT5UYNvom3WnOhOwZrQbvDwY5_dx6KHoKYP04mujTFrSiSgnFe1nJt_-Qt2mb61cuEBNKqj92dA_ZnACyH-6jUKKXMvW-TF3L1EuZuq0zbx6_4X7ib3sVeHcADFgzDtlEG-CBk7KjkrDKsT0HVYo3Pj8k_P_tvwEHXLpc
CitedBy_id crossref_primary_10_1007_s13410_015_0337_9
crossref_primary_10_1016_j_ebiom_2016_06_002
crossref_primary_10_1371_journal_pone_0053944
crossref_primary_10_1016_j_jped_2019_05_006
crossref_primary_10_1089_dia_2012_0326
crossref_primary_10_1186_1471_2458_14_1239
crossref_primary_10_1016_j_diabres_2012_09_044
crossref_primary_10_1016_j_diabres_2013_09_001
crossref_primary_10_1186_1476_511X_11_155
crossref_primary_10_3389_fendo_2020_00274
crossref_primary_10_1080_09723757_2017_1383655
crossref_primary_10_1155_2019_3618103
crossref_primary_10_1093_ndt_gfz145
crossref_primary_10_1007_s00125_016_3967_7
crossref_primary_10_1016_j_gene_2013_05_075
crossref_primary_10_1371_journal_pone_0228269
crossref_primary_10_1038_s10038_019_0577_5
crossref_primary_10_1007_s10528_014_9658_5
crossref_primary_10_1371_journal_pone_0058881
crossref_primary_10_3390_genes14010083
crossref_primary_10_1016_j_mgene_2020_100771
crossref_primary_10_1080_14767058_2017_1297793
crossref_primary_10_1111_1753_0407_12449
crossref_primary_10_1007_s13225_012_0187_4
crossref_primary_10_1080_09513590_2021_1906854
crossref_primary_10_1155_2014_873679
crossref_primary_10_1016_j_genrep_2019_100465
crossref_primary_10_1089_gtmb_2015_0005
crossref_primary_10_1111_ahg_12028
crossref_primary_10_3390_genes8010016
crossref_primary_10_1161_CIRCGENETICS_111_961649
crossref_primary_10_1016_j_gendis_2015_02_009
crossref_primary_10_1371_journal_pone_0083093
crossref_primary_10_1016_j_gene_2012_10_086
crossref_primary_10_1080_10408398_2022_2141190
crossref_primary_10_1016_j_molmet_2019_03_003
crossref_primary_10_1002_oby_20606
crossref_primary_10_1016_j_jpedp_2019_05_027
crossref_primary_10_1007_s11033_021_06431_9
crossref_primary_10_1186_s12863_014_0134_3
Cites_doi 10.1186/1471-2350-11-118
10.1038/jhg.2009.7
10.2337/diacare.26.12.3331
10.1093/bioinformatics/19.1.149
10.2337/diabetes.54.1.152
10.1038/ng.520
10.2337/db09-0117
10.1038/ng.521
10.1038/nature08365
10.1038/ng2067
10.1038/ng.120
10.2337/db09-1386
10.1086/519795
10.1371/journal.pone.0002031
10.1186/1471-2350-9-59
10.1126/science.1142364
10.1016/j.metabol.2010.04.024
10.1007/s00125-006-0502-2
10.1038/nrg2544
10.1007/BF00280883
10.1038/ng.609
10.1126/science.1142382
10.1016/j.tig.2008.09.004
10.1086/302698
10.1111/j.1469-1809.2010.00580.x
10.1371/journal.pone.0009153
10.2337/db07-0634
10.1186/1471-2350-11-81
10.1371/journal.pone.0011444
10.2337/db09-1048
10.2337/db08-0284
10.1371/journal.pmed.1000268
10.1086/302193
10.2337/db08-1138
10.2337/db08-0436
10.2337/db07-0856
10.1038/ng2062
10.1126/science.1142358
10.1038/ng.290
10.1371/journal.pone.0003019
10.1093/genetics/155.2.945
10.1177/000456326900600108
10.2337/diacare.26.11.3160
ContentType Journal Article
Contributor Sarma, K V R
Smith, G D
Reddy, K S
Ramakrishnan, L
Vaz, M
Saran, R K
Mohan, M
Ebrahim, S
Kinra, S
Ahuja, R C
Bhogadi, S
Lyngdoh, T
Kurpad, A V
Das, S M
Barathi, A V
Jain, R K
Gupta, R
Potnis, S S
Prabhakaran, D
Yajnik, C S
Ben-Shlomo, Y
Patel, T
Joshi, P
Thakre, N M
Contributor_xml – sequence: 1
  givenname: S
  surname: Ebrahim
  fullname: Ebrahim, S
– sequence: 2
  givenname: S
  surname: Kinra
  fullname: Kinra, S
– sequence: 3
  givenname: K S
  surname: Reddy
  fullname: Reddy, K S
– sequence: 4
  givenname: D
  surname: Prabhakaran
  fullname: Prabhakaran, D
– sequence: 5
  givenname: T
  surname: Patel
  fullname: Patel, T
– sequence: 6
  givenname: L
  surname: Ramakrishnan
  fullname: Ramakrishnan, L
– sequence: 7
  givenname: R
  surname: Gupta
  fullname: Gupta, R
– sequence: 8
  givenname: T
  surname: Lyngdoh
  fullname: Lyngdoh, T
– sequence: 9
  givenname: R C
  surname: Ahuja
  fullname: Ahuja, R C
– sequence: 10
  givenname: R K
  surname: Saran
  fullname: Saran, R K
– sequence: 11
  givenname: P
  surname: Joshi
  fullname: Joshi, P
– sequence: 12
  givenname: N M
  surname: Thakre
  fullname: Thakre, N M
– sequence: 13
  givenname: K V R
  surname: Sarma
  fullname: Sarma, K V R
– sequence: 14
  givenname: S M
  surname: Das
  fullname: Das, S M
– sequence: 15
  givenname: R K
  surname: Jain
  fullname: Jain, R K
– sequence: 16
  givenname: S S
  surname: Potnis
  fullname: Potnis, S S
– sequence: 17
  givenname: S
  surname: Bhogadi
  fullname: Bhogadi, S
– sequence: 18
  givenname: A V
  surname: Kurpad
  fullname: Kurpad, A V
– sequence: 19
  givenname: M
  surname: Vaz
  fullname: Vaz, M
– sequence: 20
  givenname: A V
  surname: Barathi
  fullname: Barathi, A V
– sequence: 21
  givenname: M
  surname: Mohan
  fullname: Mohan, M
– sequence: 22
  givenname: C S
  surname: Yajnik
  fullname: Yajnik, C S
– sequence: 23
  givenname: G D
  surname: Smith
  fullname: Smith, G D
– sequence: 24
  givenname: Y
  surname: Ben-Shlomo
  fullname: Ben-Shlomo, Y
Copyright The Author(s) 2011
2015 INIST-CNRS
Springer-Verlag 2012
Copyright_xml – notice: The Author(s) 2011
– notice: 2015 INIST-CNRS
– notice: Springer-Verlag 2012
CorporateAuthor Indian Migration Study Group
for the Indian Migration Study Group
CorporateAuthor_xml – name: Indian Migration Study Group
– name: for the Indian Migration Study Group
DBID C6C
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7T5
7X7
7XB
88E
8AO
8C1
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
H94
K9.
M0S
M1P
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1007/s00125-011-2355-6
DatabaseName SpringerOpen
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central
ProQuest One Community College
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Public Health
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Pharma Collection
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
AIDS and Cancer Research Abstracts
Immunology Abstracts
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
ProQuest Public Health
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1432-0428
EndPage 357
ExternalDocumentID 2546537511
10_1007_s00125_011_2355_6
22052079
25571502
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Asia
India
Europe
United Kingdom--UK
GeographicLocations_xml – name: Europe
– name: India
– name: United Kingdom--UK
GrantInformation_xml – fundername: Wellcome Trust
– fundername: Wellcome Trust
  grantid: 083541/Z/07/Z
– fundername: Wellcome Trust
  grantid: 084674
– fundername: Medical Research Council
  grantid: G0600705
– fundername: Medical Research Council
  grantid: G0800582
– fundername: Medical Research Council
  grantid: G1000718
– fundername: Wellcome Trust
  grantid: GR070797MF
GroupedDBID ---
-53
-5E
-5G
-BR
-EM
-Y2
-~C
.55
.86
.GJ
.VR
06C
06D
0R~
0VY
199
1CY
1N0
1SB
2.D
203
28-
29F
29G
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
36B
3O-
3V.
4.4
406
408
409
40D
40E
53G
5GY
5QI
5RE
5VS
67Z
6NX
78A
7X7
88E
8AO
8C1
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
A8Z
AAAVM
AABHQ
AABYN
AAFGU
AAHNG
AAIAL
AAJKR
AAKSU
AANXM
AANZL
AAPBV
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
ABBBX
ABBXA
ABDZT
ABECU
ABFGW
ABFTV
ABHLI
ABHQN
ABIPD
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABLJU
ABMNI
ABMQK
ABNWP
ABOCM
ABPLI
ABQBU
ABSXP
ABTEG
ABTKH
ABTMW
ABULA
ABUWG
ABUWZ
ABWNU
ABXPI
ACBMV
ACBRV
ACBXY
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACTTH
ACUDM
ACVWB
ACWMK
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADJJI
ADKNI
ADKPE
ADMDM
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEEQQ
AEFIE
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AEQTP
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFAFS
AFDYV
AFEXP
AFFNX
AFJLC
AFKRA
AFLOW
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGJBK
AGKHE
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHSBF
AHVUH
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKMHD
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BBWZM
BDATZ
BENPR
BGNMA
BPHCQ
BVXVI
C6C
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
EBLON
EBS
EIOEI
EJD
EMB
EMOBN
EN4
ESBYG
ESTFP
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GRRUI
GXS
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
IMOTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
J5H
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
L7B
LAS
LLZTM
M1P
M4Y
MA-
MVM
N2Q
N9A
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
P2P
P6G
P9S
PF0
PQQKQ
PROAC
PSQYO
PT4
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
ROL
RPX
RRX
RSV
S16
S1Z
S26
S27
S28
S37
S3B
SAP
SCLPG
SDE
SDH
SDM
SHX
SISQX
SJYHP
SMD
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZ9
SZN
T13
T16
TEORI
TR2
TSG
TSK
TSV
TT1
TUC
U2A
U9L
UG4
UKHRP
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WH7
WJK
WK8
X7M
YLTOR
Z45
Z5O
Z7U
Z7V
Z7W
Z7X
Z7Z
Z81
Z82
Z83
Z86
Z87
Z88
Z8O
Z8P
Z8Q
Z8T
Z8U
Z8V
Z8W
Z91
Z92
ZA5
ZGI
ZMTXR
ZOVNA
~EX
~KM
08R
AAUGY
H13
IQODW
AAEOY
AAJBT
AASML
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AFDJF
AGQEE
AGRTI
AIGIU
CGR
CUY
CVF
ECM
EIF
NPM
AACDK
AAEWM
AAYXX
AJOOF
ALIPV
CITATION
7T5
7XB
8FK
H94
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c498t-5c1ed5c3194f30dfe8cf33c797c9edd2437925caccd854a43de937f9aa9638603
IEDL.DBID U2A
ISSN 0012-186X
IngestDate Tue Sep 17 21:22:14 EDT 2024
Fri Aug 16 02:18:35 EDT 2024
Fri Sep 13 03:15:34 EDT 2024
Thu Sep 12 16:53:04 EDT 2024
Thu May 23 23:38:31 EDT 2024
Sun Oct 22 16:05:11 EDT 2023
Sat Dec 16 12:03:51 EST 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Intermediate traits
Type 2 diabetes
Association
Polymorphisms
India
Endocrinopathy
Metabolic diseases
Indian
Polymorphism
Language English
License CC BY 4.0
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c498t-5c1ed5c3194f30dfe8cf33c797c9edd2437925caccd854a43de937f9aa9638603
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://link.springer.com/10.1007/s00125-011-2355-6
PMID 22052079
PQID 912495921
PQPubID 48469
PageCount 9
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3245821
proquest_miscellaneous_919949385
proquest_journals_912495921
crossref_primary_10_1007_s00125_011_2355_6
pubmed_primary_22052079
pascalfrancis_primary_25571502
springer_journals_10_1007_s00125_011_2355_6
PublicationCentury 2000
PublicationDate 2012-02-01
PublicationDateYYYYMMDD 2012-02-01
PublicationDate_xml – month: 02
  year: 2012
  text: 2012-02-01
  day: 01
PublicationDecade 2010
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Heidelberg
– name: Germany
PublicationSubtitle Clinical and Experimental Diabetes and Metabolism
PublicationTitle Diabetologia
PublicationTitleAbbrev Diabetologia
PublicationTitleAlternate Diabetologia
PublicationYear 2012
Publisher Springer-Verlag
Springer
Springer Nature B.V
Publisher_xml – name: Springer-Verlag
– name: Springer
– name: Springer Nature B.V
References Gupta, Khadgawat, Ng, Kumar, Aggarwal, Rao, Sachdeva (CR12) 2010; 74
Unwin, Whiting, Gan, Jacqmain, Ghyoot (CR3) 2009
Cauchi, Meyre, Durand (CR43) 2008; 3
Simonis-Bik, Nijpels, van Haeften (CR34) 2010; 59
Abecasis, Cardon, Cookson (CR27) 2000; 66
Grarup, Rose, Andersson (CR36) 2007; 56
Scott, Mohlke, Bonnycastle (CR20) 2007; 316
Grarup, Andersen, Krarup (CR35) 2008; 57
Han, Luo, Ren (CR41) 2010; 11
Pascoe, Tura, Patel (CR42) 2007; 56
Prokopenko, McCarthy, Lindgren (CR2) 2008; 24
Sanghera, Ortega, Han (CR11) 2008; 9
Purcell, Cherny, Sham (CR24) 2003; 19
Chandak, Janipalli, Bhaskar (CR10) 2007; 50
Chidambaram, Radha, Mohan (CR13) 2010; 59
Sjöstrand, Gudbjörnsdottir, Strindberg, Lönnroth (CR18) 2005; 54
Prokopenko, Langenberg, Florez (CR31) 2009; 41
Ioannidis, Thomas, Daly (CR7) 2009; 10
Reich, Thangaraj, Patterson, Price, Singh (CR16) 2009; 461
Purcell, Neale, Todd-Brown (CR25) 2007; 81
Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (CR19) 1985; 28
Nair, Sugunan, Kumar, Anilkumar (CR8) 2010; 5
Gudmundsson, Sulem, Steinthorsdottir (CR39) 2007; 39
Sandhu, Weedon, Fawcett (CR22) 2007; 39
Zeggini, Weedon, Lindgren (CR38) 2007; 316
Staiger, Machicao, Kantartzis (CR44) 2008; 3
Voight, Scott, Steinthorsdottir (CR4) 2010; 42
Genuth, Alberti, Bennett (CR1) 2003; 26
Trinder (CR17) 1968; 6
Ebrahim, Kinra, Bowen (CR29) 2010; 7
Tan, Nurbaya, Gardner, Ye, Tai, Ng (CR32) 2009; 58
Fulker, Cherny, Sham, Hewitt (CR26) 1996; 64
Sugunan, Nair, Kumar, Gopalakrishnapillai (CR9) 2010; 11
Wen, Ronn, Olsso (CR40) 2010; 5
Dupuis, Langenberg, Prokopenko (CR5) 2010; 42
Pritchard, Stephens, Donnelly (CR30) 2000; 155
Zeggini, Scott, Saxena (CR23) 2008; 40
Moore, Jablonski, McAteer (CR37) 2008; 57
Chauhan, Spurgeon, Tabassum (CR15) 2010; 59
Saxena, Hivert, Langenberg (CR6) 2010; 42
Benjamini, Hochberg (CR28) 1995; 57
Saxena, Voight, Lyssenko (CR21) 2007; 316
Stancáková, Kuulasmaa, Paananen (CR33) 2009; 58
Sanghera, Been, Ortega (CR14) 2009; 54
S Ebrahim (2355_CR29) 2010; 7
V Gupta (2355_CR12) 2010; 74
DK Sanghera (2355_CR14) 2009; 54
A Stancáková (2355_CR33) 2009; 58
JK Pritchard (2355_CR30) 2000; 155
AK Nair (2355_CR8) 2010; 5
GR Chandak (2355_CR10) 2007; 50
BF Voight (2355_CR4) 2010; 42
G Chauhan (2355_CR15) 2010; 59
J Gudmundsson (2355_CR39) 2007; 39
R Saxena (2355_CR6) 2010; 42
M Sjöstrand (2355_CR18) 2005; 54
H Staiger (2355_CR44) 2008; 3
DK Sanghera (2355_CR11) 2008; 9
P Trinder (2355_CR17) 1968; 6
JT Tan (2355_CR32) 2009; 58
Y Benjamini (2355_CR28) 1995; 57
GR Abecasis (2355_CR27) 2000; 66
LJ Scott (2355_CR20) 2007; 316
D Sugunan (2355_CR9) 2010; 11
AM Simonis-Bik (2355_CR34) 2010; 59
X Han (2355_CR41) 2010; 11
N Grarup (2355_CR35) 2008; 57
AF Moore (2355_CR37) 2008; 57
I Prokopenko (2355_CR2) 2008; 24
MS Sandhu (2355_CR22) 2007; 39
J Wen (2355_CR40) 2010; 5
N Unwin (2355_CR3) 2009
E Zeggini (2355_CR23) 2008; 40
DW Fulker (2355_CR26) 1996; 64
S Cauchi (2355_CR43) 2008; 3
D Reich (2355_CR16) 2009; 461
R Saxena (2355_CR21) 2007; 316
M Chidambaram (2355_CR13) 2010; 59
I Prokopenko (2355_CR31) 2009; 41
S Purcell (2355_CR24) 2003; 19
N Grarup (2355_CR36) 2007; 56
JP Ioannidis (2355_CR7) 2009; 10
DR Matthews (2355_CR19) 1985; 28
S Purcell (2355_CR25) 2007; 81
J Dupuis (2355_CR5) 2010; 42
L Pascoe (2355_CR42) 2007; 56
S Genuth (2355_CR1) 2003; 26
E Zeggini (2355_CR38) 2007; 316
References_xml – volume: 11
  start-page: 118
  year: 2010
  ident: CR9
  article-title: A case–control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-11-118
  contributor:
    fullname: Gopalakrishnapillai
– volume: 155
  start-page: 945
  year: 2000
  end-page: 959
  ident: CR30
  article-title: Inference of population structure using multilocus genotype data
  publication-title: Genetics
  contributor:
    fullname: Donnelly
– volume: 54
  start-page: 162
  year: 2009
  end-page: 168
  ident: CR14
  article-title: Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
  publication-title: J Hum Genet
  doi: 10.1038/jhg.2009.7
  contributor:
    fullname: Ortega
– year: 2009
  ident: CR3
  publication-title: International Diabetes Federation Diabetes Atlas. IDF Diabetes Atlas
  contributor:
    fullname: Ghyoot
– volume: 26
  start-page: 3160
  year: 2003
  end-page: 3167
  ident: CR1
  article-title: The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: follow-up report on the diagnosis of diabetes mellitus
  publication-title: Diabetes Care
  doi: 10.2337/diacare.26.12.3331
  contributor:
    fullname: Bennett
– volume: 19
  start-page: 149
  year: 2003
  end-page: 150
  ident: CR24
  article-title: Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/19.1.149
  contributor:
    fullname: Sham
– volume: 54
  start-page: 152
  year: 2005
  end-page: 157
  ident: CR18
  article-title: Delayed transcapillary delivery of insulin to muscle interstitial fluid after oral glucose load in obese subjects
  publication-title: Diabetes
  doi: 10.2337/diabetes.54.1.152
  contributor:
    fullname: Lönnroth
– volume: 42
  start-page: 105
  year: 2010
  end-page: 116
  ident: CR5
  article-title: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
  publication-title: Nat Genet
  doi: 10.1038/ng.520
  contributor:
    fullname: Prokopenko
– volume: 58
  start-page: 2129
  year: 2009
  end-page: 2136
  ident: CR33
  article-title: Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
  publication-title: Diabetes
  doi: 10.2337/db09-0117
  contributor:
    fullname: Paananen
– volume: 42
  start-page: 142
  year: 2010
  end-page: 148
  ident: CR6
  article-title: Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
  publication-title: Nat Genet
  doi: 10.1038/ng.521
  contributor:
    fullname: Langenberg
– volume: 57
  start-page: 289
  year: 1995
  end-page: 300
  ident: CR28
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J R Stat Soc B
  contributor:
    fullname: Hochberg
– volume: 461
  start-page: 489
  year: 2009
  end-page: 494
  ident: CR16
  article-title: Reconstructing Indian population history
  publication-title: Nature
  doi: 10.1038/nature08365
  contributor:
    fullname: Singh
– volume: 39
  start-page: 951
  year: 2007
  end-page: 953
  ident: CR22
  article-title: Common variants in WFS1 confer risk of type 2 diabetes
  publication-title: Nat Genet
  doi: 10.1038/ng2067
  contributor:
    fullname: Fawcett
– volume: 40
  start-page: 638
  year: 2008
  end-page: 645
  ident: CR23
  article-title: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
  publication-title: Nat Genet
  doi: 10.1038/ng.120
  contributor:
    fullname: Saxena
– volume: 59
  start-page: 2068
  year: 2010
  end-page: 2074
  ident: CR15
  article-title: Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians
  publication-title: Diabetes
  doi: 10.2337/db09-1386
  contributor:
    fullname: Tabassum
– volume: 6
  start-page: 24
  year: 1968
  end-page: 27
  ident: CR17
  article-title: Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor
  publication-title: Ann Clin Biochem
  contributor:
    fullname: Trinder
– volume: 81
  start-page: 559
  year: 2007
  end-page: 575
  ident: CR25
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
  contributor:
    fullname: Todd-Brown
– volume: 3
  start-page: e2031
  year: 2008
  ident: CR43
  article-title: Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002031
  contributor:
    fullname: Durand
– volume: 9
  start-page: 59
  year: 2008
  ident: CR11
  article-title: Impact of nine common T2D risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-9-59
  contributor:
    fullname: Han
– volume: 316
  start-page: 1336
  year: 2007
  end-page: 1341
  ident: CR38
  article-title: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
  publication-title: Science
  doi: 10.1126/science.1142364
  contributor:
    fullname: Lindgren
– volume: 59
  start-page: 1760
  year: 2010
  end-page: 1766
  ident: CR13
  article-title: Replication of recently described type 2 dabetes gene variants in a South Indian population
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2010.04.024
  contributor:
    fullname: Mohan
– volume: 50
  start-page: 63
  year: 2007
  end-page: 67
  ident: CR10
  article-title: Common variants in the TCF7L2 gene are strongly associated with T2D mellitus in the Indian population
  publication-title: Diabetologia
  doi: 10.1007/s00125-006-0502-2
  contributor:
    fullname: Bhaskar
– volume: 10
  start-page: 318
  issue: 5
  year: 2009
  end-page: 329
  ident: CR7
  article-title: Validating, augmenting and refining genome-wide association signals
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2544
  contributor:
    fullname: Daly
– volume: 28
  start-page: 412
  year: 1985
  end-page: 419
  ident: CR19
  article-title: Homeostasis model assessment: insulin resistance and B cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
  contributor:
    fullname: Turner
– volume: 42
  start-page: 579
  year: 2010
  end-page: 589
  ident: CR4
  article-title: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
  publication-title: Nat Genet
  doi: 10.1038/ng.609
  contributor:
    fullname: Steinthorsdottir
– volume: 316
  start-page: 1341
  year: 2007
  end-page: 1345
  ident: CR20
  article-title: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
  publication-title: Science
  doi: 10.1126/science.1142382
  contributor:
    fullname: Bonnycastle
– volume: 24
  start-page: 613
  year: 2008
  end-page: 621
  ident: CR2
  article-title: Type 2 diabetes: new genes, new understanding
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2008.09.004
  contributor:
    fullname: Lindgren
– volume: 66
  start-page: 279
  year: 2000
  end-page: 292
  ident: CR27
  article-title: A general test of association for quantitative traits in nuclear families
  publication-title: Am J Hum Genet
  doi: 10.1086/302698
  contributor:
    fullname: Cookson
– volume: 74
  start-page: 361
  year: 2010
  end-page: 368
  ident: CR12
  article-title: A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India
  publication-title: Ann Hum Genet
  doi: 10.1111/j.1469-1809.2010.00580.x
  contributor:
    fullname: Sachdeva
– volume: 5
  start-page: e9153
  year: 2010
  ident: CR40
  article-title: Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009153
  contributor:
    fullname: Olsso
– volume: 56
  start-page: 3101
  year: 2007
  end-page: 3104
  ident: CR42
  article-title: Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
  publication-title: Diabetes
  doi: 10.2337/db07-0634
  contributor:
    fullname: Patel
– volume: 11
  start-page: 81
  year: 2010
  ident: CR41
  article-title: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-11-81
  contributor:
    fullname: Ren
– volume: 5
  start-page: e11444
  year: 2010
  ident: CR8
  article-title: Case–control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0011444
  contributor:
    fullname: Anilkumar
– volume: 59
  start-page: 293
  year: 2010
  end-page: 301
  ident: CR34
  article-title: Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
  publication-title: Diabetes
  doi: 10.2337/db09-1048
  contributor:
    fullname: van Haeften
– volume: 57
  start-page: 2503
  year: 2008
  end-page: 2510
  ident: CR37
  article-title: Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
  publication-title: Diabetes
  doi: 10.2337/db08-0284
  contributor:
    fullname: McAteer
– volume: 7
  start-page: e1000268
  year: 2010
  ident: CR29
  article-title: The effect of rural-to-urban migration on obesity and diabetes in India: a cross-sectional study
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000268
  contributor:
    fullname: Bowen
– volume: 64
  start-page: 259
  year: 1996
  end-page: 267
  ident: CR26
  article-title: Combined linkage and association sib-pair analysis for quantitative traits
  publication-title: Am J Hum Genet
  doi: 10.1086/302193
  contributor:
    fullname: Hewitt
– volume: 58
  start-page: 1445
  year: 2009
  end-page: 1449
  ident: CR32
  article-title: Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore
  publication-title: Diabetes
  doi: 10.2337/db08-1138
  contributor:
    fullname: Ng
– volume: 57
  start-page: 2534
  year: 2008
  end-page: 2540
  ident: CR35
  article-title: Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
  publication-title: Diabetes
  doi: 10.2337/db08-0436
  contributor:
    fullname: Krarup
– volume: 56
  start-page: 3105
  year: 2007
  end-page: 3111
  ident: CR36
  article-title: Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
  publication-title: Diabetes
  doi: 10.2337/db07-0856
  contributor:
    fullname: Andersson
– volume: 39
  start-page: 977
  year: 2007
  end-page: 983
  ident: CR39
  article-title: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
  publication-title: Nat Genet
  doi: 10.1038/ng2062
  contributor:
    fullname: Steinthorsdottir
– volume: 316
  start-page: 1331
  year: 2007
  end-page: 1336
  ident: CR21
  article-title: Genome-wide association analysis identifies loci for T2D and triglyceride levels
  publication-title: Science
  doi: 10.1126/science.1142358
  contributor:
    fullname: Lyssenko
– volume: 41
  start-page: 77
  year: 2009
  end-page: 81
  ident: CR31
  article-title: Variants in MTNR1B influence fasting glucose levels
  publication-title: Nat Genet
  doi: 10.1038/ng.290
  contributor:
    fullname: Florez
– volume: 3
  start-page: e3019
  year: 2008
  ident: CR44
  article-title: Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003019
  contributor:
    fullname: Kantartzis
– volume: 50
  start-page: 63
  year: 2007
  ident: 2355_CR10
  publication-title: Diabetologia
  doi: 10.1007/s00125-006-0502-2
  contributor:
    fullname: GR Chandak
– volume: 54
  start-page: 162
  year: 2009
  ident: 2355_CR14
  publication-title: J Hum Genet
  doi: 10.1038/jhg.2009.7
  contributor:
    fullname: DK Sanghera
– volume: 59
  start-page: 1760
  year: 2010
  ident: 2355_CR13
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2010.04.024
  contributor:
    fullname: M Chidambaram
– volume: 39
  start-page: 977
  year: 2007
  ident: 2355_CR39
  publication-title: Nat Genet
  doi: 10.1038/ng2062
  contributor:
    fullname: J Gudmundsson
– volume: 5
  start-page: e9153
  year: 2010
  ident: 2355_CR40
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009153
  contributor:
    fullname: J Wen
– volume: 57
  start-page: 289
  year: 1995
  ident: 2355_CR28
  publication-title: J R Stat Soc B
  contributor:
    fullname: Y Benjamini
– volume: 3
  start-page: e2031
  year: 2008
  ident: 2355_CR43
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002031
  contributor:
    fullname: S Cauchi
– volume: 56
  start-page: 3101
  year: 2007
  ident: 2355_CR42
  publication-title: Diabetes
  doi: 10.2337/db07-0634
  contributor:
    fullname: L Pascoe
– volume: 39
  start-page: 951
  year: 2007
  ident: 2355_CR22
  publication-title: Nat Genet
  doi: 10.1038/ng2067
  contributor:
    fullname: MS Sandhu
– volume: 42
  start-page: 579
  year: 2010
  ident: 2355_CR4
  publication-title: Nat Genet
  doi: 10.1038/ng.609
  contributor:
    fullname: BF Voight
– volume: 42
  start-page: 142
  year: 2010
  ident: 2355_CR6
  publication-title: Nat Genet
  doi: 10.1038/ng.521
  contributor:
    fullname: R Saxena
– volume: 57
  start-page: 2534
  year: 2008
  ident: 2355_CR35
  publication-title: Diabetes
  doi: 10.2337/db08-0436
  contributor:
    fullname: N Grarup
– volume: 461
  start-page: 489
  year: 2009
  ident: 2355_CR16
  publication-title: Nature
  doi: 10.1038/nature08365
  contributor:
    fullname: D Reich
– volume: 56
  start-page: 3105
  year: 2007
  ident: 2355_CR36
  publication-title: Diabetes
  doi: 10.2337/db07-0856
  contributor:
    fullname: N Grarup
– volume: 28
  start-page: 412
  year: 1985
  ident: 2355_CR19
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
  contributor:
    fullname: DR Matthews
– volume: 5
  start-page: e11444
  year: 2010
  ident: 2355_CR8
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0011444
  contributor:
    fullname: AK Nair
– volume: 316
  start-page: 1341
  year: 2007
  ident: 2355_CR20
  publication-title: Science
  doi: 10.1126/science.1142382
  contributor:
    fullname: LJ Scott
– volume: 57
  start-page: 2503
  year: 2008
  ident: 2355_CR37
  publication-title: Diabetes
  doi: 10.2337/db08-0284
  contributor:
    fullname: AF Moore
– volume: 66
  start-page: 279
  year: 2000
  ident: 2355_CR27
  publication-title: Am J Hum Genet
  doi: 10.1086/302698
  contributor:
    fullname: GR Abecasis
– volume: 155
  start-page: 945
  year: 2000
  ident: 2355_CR30
  publication-title: Genetics
  doi: 10.1093/genetics/155.2.945
  contributor:
    fullname: JK Pritchard
– volume-title: International Diabetes Federation Diabetes Atlas. IDF Diabetes Atlas
  year: 2009
  ident: 2355_CR3
  contributor:
    fullname: N Unwin
– volume: 41
  start-page: 77
  year: 2009
  ident: 2355_CR31
  publication-title: Nat Genet
  doi: 10.1038/ng.290
  contributor:
    fullname: I Prokopenko
– volume: 3
  start-page: e3019
  year: 2008
  ident: 2355_CR44
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003019
  contributor:
    fullname: H Staiger
– volume: 11
  start-page: 81
  year: 2010
  ident: 2355_CR41
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-11-81
  contributor:
    fullname: X Han
– volume: 42
  start-page: 105
  year: 2010
  ident: 2355_CR5
  publication-title: Nat Genet
  doi: 10.1038/ng.520
  contributor:
    fullname: J Dupuis
– volume: 19
  start-page: 149
  year: 2003
  ident: 2355_CR24
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/19.1.149
  contributor:
    fullname: S Purcell
– volume: 10
  start-page: 318
  issue: 5
  year: 2009
  ident: 2355_CR7
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2544
  contributor:
    fullname: JP Ioannidis
– volume: 40
  start-page: 638
  year: 2008
  ident: 2355_CR23
  publication-title: Nat Genet
  doi: 10.1038/ng.120
  contributor:
    fullname: E Zeggini
– volume: 59
  start-page: 293
  year: 2010
  ident: 2355_CR34
  publication-title: Diabetes
  doi: 10.2337/db09-1048
  contributor:
    fullname: AM Simonis-Bik
– volume: 11
  start-page: 118
  year: 2010
  ident: 2355_CR9
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-11-118
  contributor:
    fullname: D Sugunan
– volume: 81
  start-page: 559
  year: 2007
  ident: 2355_CR25
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
  contributor:
    fullname: S Purcell
– volume: 58
  start-page: 1445
  year: 2009
  ident: 2355_CR32
  publication-title: Diabetes
  doi: 10.2337/db08-1138
  contributor:
    fullname: JT Tan
– volume: 6
  start-page: 24
  year: 1968
  ident: 2355_CR17
  publication-title: Ann Clin Biochem
  doi: 10.1177/000456326900600108
  contributor:
    fullname: P Trinder
– volume: 64
  start-page: 259
  year: 1996
  ident: 2355_CR26
  publication-title: Am J Hum Genet
  doi: 10.1086/302193
  contributor:
    fullname: DW Fulker
– volume: 7
  start-page: e1000268
  year: 2010
  ident: 2355_CR29
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000268
  contributor:
    fullname: S Ebrahim
– volume: 54
  start-page: 152
  year: 2005
  ident: 2355_CR18
  publication-title: Diabetes
  doi: 10.2337/diabetes.54.1.152
  contributor:
    fullname: M Sjöstrand
– volume: 316
  start-page: 1331
  year: 2007
  ident: 2355_CR21
  publication-title: Science
  doi: 10.1126/science.1142358
  contributor:
    fullname: R Saxena
– volume: 59
  start-page: 2068
  year: 2010
  ident: 2355_CR15
  publication-title: Diabetes
  doi: 10.2337/db09-1386
  contributor:
    fullname: G Chauhan
– volume: 26
  start-page: 3160
  year: 2003
  ident: 2355_CR1
  publication-title: Diabetes Care
  doi: 10.2337/diacare.26.11.3160
  contributor:
    fullname: S Genuth
– volume: 316
  start-page: 1336
  year: 2007
  ident: 2355_CR38
  publication-title: Science
  doi: 10.1126/science.1142364
  contributor:
    fullname: E Zeggini
– volume: 58
  start-page: 2129
  year: 2009
  ident: 2355_CR33
  publication-title: Diabetes
  doi: 10.2337/db09-0117
  contributor:
    fullname: A Stancáková
– volume: 74
  start-page: 361
  year: 2010
  ident: 2355_CR12
  publication-title: Ann Hum Genet
  doi: 10.1111/j.1469-1809.2010.00580.x
  contributor:
    fullname: V Gupta
– volume: 24
  start-page: 613
  year: 2008
  ident: 2355_CR2
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2008.09.004
  contributor:
    fullname: I Prokopenko
– volume: 9
  start-page: 59
  year: 2008
  ident: 2355_CR11
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-9-59
  contributor:
    fullname: DK Sanghera
SSID ssj0003546
Score 2.287249
Snippet Aims/hypothesis Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell...
Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β),...
AIMS/HYPOTHESISEvaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 349
SubjectTerms Adult
Alleles
Biological and medical sciences
Blood Glucose - metabolism
Chronic illnesses
Diabetes
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Europe
Family Health
Female
Genomes
Genomics
Genotype
Glucose
Human Physiology
Humans
India
Insulin - blood
Insulin - metabolism
Insulin resistance
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Migration
Phenotype
Polymorphism, Genetic
Quantitative Trait Loci
Risk
Siblings
Transients and Migrants
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB6VIiEkhMqrhJZqDpxA1ibOw_EJIdRSkMqJSnuLHNsRK9EkkPTAv2fGm6Qsjx6jPBT7mxmPZzzfALzKEuWU9LGwJmZSbZWJ2hVW1GQZHQlNoxqud774XJxfZp_W-XoPPsy1MHyscraJwVC7znKMfKVDl2Qtk5WpOQhgx9Xb_rvg9lGcZp16adyBu4kkr4IEW62XnVecThU7ZI1FUhbrOb0ZBzZRWuMFRwolrb2i2FmgHvRmoLlqtk0u_uWF_n2Y8o-Maliozg7g4eRh4rutSDyCPd8-hnsXUw79CXS_IYJm4iTBrsE0QZoKGh723befVx0hsBmuBuRQLXKoFiXOoVp60eFmHDDUwniH3GqCLjctfmxZ5JBUDXtOFj2Fy7PTL-_PxdR2QdhMl6PIbeJdbkk3syaNXeNL26SpVVpZ7Z0LDIYyt8ZaV-aZyVLnycdptDGszEWcPoP9tmv9c0ApS29iVzDLPO3DyViQfVAyL-uS96U6gtfzXFf9ll2jWniUAzAVAVMxMFURwckOGssbtCtS5NfKCI5meKpJE4dqkZsIcLlLKsR5EdP67pof0TrTaZlHcLjF8ubTks8JKfpRtYPy8gCzc-_eaTdfA0s3eapchBzBm1kebn7qv2N8cesQjuC-ZBEOh8aPYX_8ce1fkk801idB3n8B7KYJSw
  priority: 102
  providerName: ProQuest
Title Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
URI https://link.springer.com/article/10.1007/s00125-011-2355-6
https://www.ncbi.nlm.nih.gov/pubmed/22052079
https://www.proquest.com/docview/912495921/abstract/
https://search.proquest.com/docview/919949385
https://pubmed.ncbi.nlm.nih.gov/PMC3245821
Volume 55
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LjtMwcLQPCSEhxJuwUM2BEygocR62j6XqsoB2hRCVyilybUdbAUlFuv_PjJtkKSwHLokSP2R73h7PGOBlnkonhU9iaxJOqi3zeOVKG6-IMzpCmlrWHO98flGeLfIPy2J5AGLcumi-vRk8koFRj7FuLJj5nFkaC5KRcXkIx6w7MCYvxHTkvlkfnEO141SVy8GTeVMXe7LozsZ0tCz17j6LmxTOv89N_uE8DTLp9B7c7ZVJnO6gfx8OfPMAbp337vKH0P62-Gj69CPY1pilSLMmDMRN-52sf1rsdfejQ96VRd6VRYHDriw1dLjedhjCXrxDvlWCPtcNvm8Yu5CoCjfsF3oEi9P5l9lZ3N-wENtcq21c2NS7whIZ5nWWuNorW2eZlVpa7Z0LyQpFYY21ThW5yTPnSZ2ptTFMt2WSPYajpm38U0AhlDeJKzmhPJncxBeIFUhRqJViE1RH8GpY62qzS6RRjSmTA2AqAkzFgKnKCCZ70BhbkAEkSYUVEZwM4Kl6ousqHS7S1iKNAMdSohZ2gZjGt1dcRetcZ6qI4MkOltddCz4SJGmgcg_KYwVOxL1f0qwvQ0JuUko53jiC1wM-XA_qn3N89l-1T-C2YJQO58Wfw9H255V_QerQdjWBQ7mU9FSzdALH03dfP87p_XZ-8ekz_Z2Vs0mgkF9ZEAe3
link.rule.ids 230,315,786,790,891,12083,12250,21416,27957,27958,31754,31755,33301,33302,33779,33780,41116,41155,41558,42185,42224,42627,43345,43614,43840,51611,52146,52269,74102,74371,74659
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BkaASQrwJheIDJ5BFYidxfEKootpCt6dW2lvktR11JZqEZnvg3zPjdbIsr2OUh2LP0_P4BuBtnimnhE-5NSmBaqucL11p-RI1o0OmaVRD_c7zs3J2kX9ZFItYmzPEsspRJwZF7TpLMfIPOkxJ1iL72H_nNDSKkqtxgsZtuJNLtDPUKH60rfCQsU8HdTDPqnIxJjXTgCGKlp1TfFCgxeXljlm635sBd6jZjLb4m-_5Zwnlb3nUYJ6OH8KD6FeyTxtGeAS3fPsY7s5j5vwJdL_QgZmIRMK6hsmM4Qbg8ljffftx1eG-r4argVGAllGAlgk2BmjxRcdW64GFDhjvGA2YwMtVy05aYjSGAsZ6ShE9hYvjz-dHMx6HLXCb62rNC5t5V1iUyLyRqWt8ZRsprdLKau9cwC0UhTXWuqrITS6dR8-m0caQCJepfAZ7bdf6F8CEqLxJXUnY8nj6RhWBWkGJolpWdBrVCbwb97ruN5ga9YSeHAhTI2FqIkxdJnC4Q43pDTwLKfRmRQIHI3nqKH9DPXFLAmy6i4JD2RDT-u6GHtE617IqEni-oeX204KqgxT-qNqh8vQAYXLv3mlXlwGbG_1Taj1O4P3ID9uf-ucaX_53CW_g3ux8flqfnpx9PYB9QewcysZfwd76-sa_Rq9ovTwMvP8TdeQISQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BK1VICPEmFIoPnEBWE8eJ4xPi0VULdFUhKu0t8vohVqJJINsD_56ZrJOyvI5RHoo934zHM-NvAJ7LTDklfMqtSYlUW0m-dKXlS7SMDkETVKDzzqfz8vhcvl8Ui0gp1MeyytEmDobatZZi5Id66JKsRXYYYlXE2bvZq-4bpwZSlGiN3TSuw66SZYEA331zND_7NJnlPJ7aQYvMs6pcjCnOdGAUxXWeU7RQ4PrLy61F6mZnepyvsGl08TdP9M-Cyt-yqsNiNbsNt6KXyV5vYHEHrvnmLuydxjz6PWh_kQozkZeEtYHlGcPpwAGyrv3646JFKaz6i55RuJZRuJYJNoZr8UXHVuueDedhvGPUbgIvVw07aQh2DNWNdZQwug_ns6PPb495bL3ArdTVmhc2866wqJ8y5KkLvrIhz63Symrv3MBiKAprrHVVIY3MnUc_J2hjSKHLNH8AO03b-EfAhKi8SV1JTPO4F0eDgTZCiaJaVrQ31Qm8GOe67jYMG_XEpTwIpkbB1CSYukzgYEsa0xu4M1Lo24oE9kfx1FEb-3rCTgJsuotqRLkR0_j2kh7RWuq8KhJ4uJHl1acF1Qop_FG1JeXpAWLo3r7TrL4MTN3ordJB5ARejni4-ql_jvHxf4fwDPYQ-PXHk_mHfbghCM1DDfkT2Fl_v_RP0UVaLw8i-H8C734OIQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+analysis+of+31+common+polymorphisms+with+type+2+diabetes+and+its+related+traits+in+Indian+sib+pairs&rft.jtitle=Diabetologia&rft.au=Gupta%2C+V.&rft.au=Vinay%2C+D.+G.&rft.au=Rafiq%2C+S.&rft.au=Kranthikumar%2C+M.+V.&rft.date=2012-02-01&rft.pub=Springer-Verlag&rft.issn=0012-186X&rft.eissn=1432-0428&rft.volume=55&rft.issue=2&rft.spage=349&rft.epage=357&rft_id=info:doi/10.1007%2Fs00125-011-2355-6&rft.externalDocID=10_1007_s00125_011_2355_6
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-186X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-186X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-186X&client=summon