Heat Shock Protein 72 Is Associated with the Hepatitis C Virus Replicase Complex and Enhances Viral RNA Replication

• Published in: The Journal of biological chemistry Vol. 285; no. 36; pp. 28183 - 28190
• Main Authors: Chen, Yin-Ju, Chen, Yu-Hsuan, Chow, Lu-Ping, Tsai, Ya-Hui, Chen, Pei-Hong, Huang, Chi-Ying F., Chen, Wei-Tzu, Hwang, Lih-Hwa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.09.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Cell Line; Heat Shock Protein; Hepacivirus - enzymology; Hepacivirus - metabolism; Hepacivirus - physiology; Hepatitis C Virus; HSC70 Heat-Shock Proteins - metabolism; HSP72 Heat-Shock Proteins - metabolism; Humans; Lentivirus; Mass Spectrometry (MS); Microbiology; NS5A; Positive-strand RNA Viruses; RNA, Viral - biosynthesis; RNA-Dependent RNA Polymerase - metabolism; shRNA; Tandem Affinity Purification; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Viral Replication; Virus Replication; Positive-strand RNA Viruses; Viral Replication; Tandem Affinity Purification; shRNA; NS5A; Mass Spectrometry (MS); Lentivirus; Heat Shock Protein; Hepatitis C Virus

The NS5A protein of the hepatitis C virus (HCV) is an integral component of the viral replicase. It also modulates cellular signaling and perturbs host interferon responses. The multifunctional characteristics of NS5A are mostly attributed to its ability to interact with various cellular proteins. T...