LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase

• Published in: Acta pharmaceutica Sinica. B Vol. 11; no. 6; pp. 1578 - 1591
• Main Authors: Zou, Jie, Zhu, Xiaoyun, Xiang, Dejuan, Zhang, Yanqiu, Li, Jie, Su, Zhigui, Kong, Lingyi, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2021; Elsevier
• Subjects: FBP1; Gluconeogenesis; Glucose metabolism; Hepatocellular carcinoma; LIX1L; Metastasis; miR-21-3p; Original; Proliferation; LIX1L; Hepatocellular carcinoma; HCC; miR-21-3p; Proliferation; Metastasis; DEN; NASH; EMT; ECAR; Glucose metabolism; shRNA; CCl4; miRNA; FBP1; Seq; Gluconeogenesis

Limb and CNS expressed 1 like (LIX1L) is over-expressed in several types of tumors. However, the function of LIX1L in glucose metabolism and hepatocellular carcinoma (HCC) progression remains elusive. Here we report that LIX1L is over-expressed in human HCC tissues, which predicts unfavorable progno...