Mitochondria in mesenchymal stem cell biology and cell therapy: From cellular differentiation to mitochondrial transfer

• Published in: Seminars in cell & developmental biology Vol. 52; pp. 119 - 131
• Main Authors: Hsu, Yi-Chao, Wu, Yu-Ting, Yu, Ting-Hsien, Wei, Yau-Huei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2016
• Subjects: Animals; Cell Differentiation - physiology; Cell- and Tissue-Based Therapy - methods; Humans; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Mitochondria - metabolism; Mitochondrial metabolism; Mitochondrial transfer; Sirtuins; Sirtuins - metabolism; Stem Cell Transplantation - methods; Sirtuins; Mitochondrial transfer; O2; p70S6K; SREBP-1; PTM; OXPHOS; HIF-1α; PDHC; BM; H2O2; Mitochondrial metabolism; MSCs; Mfn; OPA1; PI3K; Complex V; NRFs; PDH; PDK; mTOR; LC3; DAPT; ESCs; Sirt; Mesenchymal stem cells; Complex II; TCA cycle; Complex III; PKC; SOD; Complex I; PGC-1α; COX; GPx; PPARγ; HLA-DR; ETC; Miro1; PSCs; CAT; ROS; TSC1/2; AMPK; FOXO3a; mtTFA; TNTs

•An integrated view on different protein kinases and sirtuins in MSCs is provided.•The regulation of mitochondrial biogenesis and metabolism in MSCs are summarized.•Recent advances in mitochondrial dynamics and transfer are discussed. Mesenchymal stem cells (MSCs) are characterized to have the capac...