Risk of autoimmunity, cancer seeding, and adverse events in human trials of whole-tissue autologous therapeutic vaccines

• Published in: Cancer pathogenesis and therapy Vol. 3; no. 2; pp. 129 - 134
• Main Authors: Gianneschi, Garrett, Scolpino, Anthony, Oleske, James
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2025; Elsevier
• Subjects: Autoimmunity; Cancer vaccines; Drug-related side effects and adverse reactions; Immunotherapy; Neoplasms; Systematic Review; Vaccination; Autoimmunity; Cancer vaccines; Drug-related side effects and adverse reactions; Vaccination; Immunotherapy; Systematic review; Neoplasms

Whole-tissue autologous therapeutic vaccines (WATVs) are a form of cancer immunotherapy that use a patient's own pathological tissue. Concerns exist regarding the potential of WATVs to induce autoimmunity or the spread of cancer; however, their adverse events (AEs) have not been adequately stud...