Evaluation of bone quality and quantity in osteoporotic mice – The effects of genistein and equol

• Published in: Phytomedicine (Stuttgart) Vol. 17; no. 6; pp. 424 - 430
• Main Authors: Sehmisch, S., Uffenorde, J., Maehlmeyer, S., Tezval, M., Jarry, H., Stuermer, K.M., Stuermer, E.K.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.05.2010; Urban & Fischer Verlag
• Subjects: Animals; Biomechanical Phenomena - drug effects; Biomechanical testing; Bone Density - drug effects; Bone Density Conservation Agents - pharmacology; Bone Density Conservation Agents - therapeutic use; Equol; Estradiol; Estradiol - pharmacology; Estradiol - therapeutic use; Female; Genetic engineering; Genistein; Genistein - pharmacology; Genistein - therapeutic use; Health aspects; Histomorphometry; Hormone therapy; Isoflavones; Isoflavones - pharmacology; Isoflavones - therapeutic use; Mice; Mice, Inbred C57BL; Mouse osteopenia model; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - pathology; Ovariectomy; Parathyroid hormone; Phytoestrogens - pharmacology; Phytoestrogens - therapeutic use; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Postmenopausal women; Resveratrol; Tibia; Germany; Ct.Dn; EQO; C; E; Genistein; fL; Equol; Ct.Ar; Histomorphometry; Mouse osteopenia model; Cn.Dn; GEN; N.Nd; yL; Biomechanical testing; BMD; Tb.Ar; Fmax

The technology of gene manipulation is often used in mice. A crucial point for osteoporosis research is the evaluation of biomechanical and morphologic parameters. These parameters, however, are difficult to measure in mice. Nevertheless, this study demonstrates the capability of using techniques fo...